Zatsopano kuchokera ku kafukufuku yemwe akupitilira mu Gawo 3 akufotokozeranso mphamvu ya VUMERITY® (Dilosimil fumarate) komanso kulolerana bwino kwa m'mimba.
Poyerekeza ndi Ocrevus® (ocrelizumab), zomwe zapezedwa zenizeni zidayesa ubwino wamoyo wokhudzana ndi TYSABRI® (natalizumab)
Zomwe zapezedwa zenizeni zimanena za ubwino wa PLEGRIDY® (peginterferon beta-1a) ndi AVONEX® (interferon beta-1a) mwa odwala okalamba omwe ali ndi multiple sclerosis.
Cambridge, Massachusetts, September 11, 2020 (Global News)-Biogen Inc. (NASDAQ: BIIB) lero yalengeza zatsopano zomwe zikuwonetsa zake zazikuluzikulu zotsogola zamagulu ambiri amtundu wa sclerosis (MS ) Kuchita bwino komanso chitetezo cha kuphatikiza kwamankhwala.Izi zidzakambidwa pamsonkhano wachisanu ndi chitatu wa MSVirtual2020, American Multiple Sclerosis Treatment and Research Committee ndi European Multiple Sclerosis Treatment and Research Committee (ACTRIMS-ECTRIMS), womwe udzachitike kuyambira Seputembara 11 mpaka 13, 2020.
"Biogen Chief Medical Officer Maha Radhakrishnan, MD, anati: "Biogen ndi wonyada chifukwa tadzipereka kuthetsa mavuto achangu komanso a nthawi yaitali omwe odwala MS amakumana nawo."Zomwe timapereka pa ACTRIMS-ECTRIMS zikuwonetsa zotsatira zabwino.Mbiri yathu yayikulu yamtundu wa MS ikupitilizabe kuthandiza odwala omwe akuyambiranso MS, ziribe kanthu komwe ali mu chithandizo chamankhwala, komanso kafukufuku wathu wopitilira muyeso ndi chitukuko Invest in the Development of omwe angakhale othandiza pamankhwala.”
Deta Yatsopano ya Phase 3 ikuwonetsanso mphamvu ya VUMERITY® (Dilosimide fumarate) ndi kulolerana kwa GI yofotokozedwa ndi odwala.Zatsopano zochokera ku pulogalamu yachipatala ya VUMERITY Phase 3 imafotokozeranso zaposachedwa kwambiri za Biogen oral fumarate therapy Kuchita bwino ndi chitetezo.Poyerekeza ndi TECFIDERA® (dimethyl fumarate) (n = 251) ndi chithandizo, zotsatira za kafukufuku wa EVOLVE-MS-2 wa masabata asanu zinalimbikitsa kulolerana kwa m'mimba (GI) kwa odwala omwe adayesedwa okhudzana ndi chithandizo cha VUMERITY Kufunika kwachipatala kwa kulandira (n = 253) imathandizira kusintha kwa moyo wa odwala omwe ali ndi MS wobwereza.Ochita nawo kafukufuku yemwe adatenga VUMERITY adanena kuti sakhala ndi zizindikiro za m'mimba zomwe zimasokoneza zochitika za tsiku ndi tsiku kapena zokhudzana ndi kusowa kwa ntchito, ndipo pali mankhwala ochepa omwe amagwiritsidwa ntchito pochiza zizindikiro za m'mimba.
Kuwunika kowunika kwa kafukufuku yemwe akupitilira EVOLVE-MS-1 adawonetsa momwe VUMERITY imasinthira kuchuluka kwaubongo ndi zizindikiro zina zachipatala mwa anthu omwe adayambiranso MS (n = 365) omwe adalandira chithandizo kwa zaka ziwiri.Kafukufuku wosiyana wasonyeza kuti kuchepa kwa ubongo kungakhale kokhudzana ndi kuwonongeka kwa chidziwitso, kulumala kwa thupi komanso kuchepa kwa moyo wa odwala MS.1,2, data ya EVOLVE-MS-1 ikuwonetsa:
Kusintha kwa voliyumu yaubongo pachaka kwa omwe adalandira chithandizo cha VUMERITY kwa zaka ziwiri kunali kofanana ndi kwa anthu athanzi.ndi
Pafupifupi 90% ya odwala omwe amalandira chithandizo cha VUMERITY alibe chidziwitso chotsimikizika cha kulemala, ndipo pafupifupi 84% alibe kubwereza mkati mwa zaka ziwiri.
Deta yomaliza yochokera ku phunziro la Phase 3 la ENDORSE idzaperekedwanso pamsonkhanowu, womwe umatsimikiziranso kuti TECFIDERA imagwira bwino ntchito komanso chitetezo chodziwika bwino kwa odwala mpaka zaka 13.
Deta yeniyeni yochokera ku kusanthula kosiyana kwa chiwerengero cha MS chokhazikika chikuwonetsa kuti kudzera mu MS PATHS (Partner Advance Technology and Health Solutions), TYSABRI® (natalizumab), PLEGRIDY® (pegylated interferon beta-1a) Ndipo AVONEX® (interferon beta-1a) zotsatira zakhala bwino., Biogen ikugwirizana ndi malo otsogola a MS ku Europe ndi United States kuti apange deta yokhazikika, yapamwamba kwambiri kuchokera kumagulu osiyanasiyana a odwala a MS.Mpaka pano, odwala opitilira 17,000 atenga nawo gawo mu MS PATHS.Zomwe zapezedwa kuchokera ku chithandizo m'malo enieni zimathandizira zotsatira zabwino zolumikizidwa ndi TYSABRI, PLEGIDYY ndi AVONEX.Zotsatira zakuwunika kosiyana ndi data ya MS PATHS zikuwonetsa:
M'kuyerekeza koyamba kwa dongosolo la MS PATHS lokhazikika la maginito a resonance imaging (MRI), zosintha panthawi yotalikirapo ya dosing (EID; n = 85) ya natalizumab idafanizidwa ndi ubongo wovomerezeka wa MRI (kutanthauza kutsatira zaka 0.8).Kamodzi pa masabata anayi aliwonse (Q4W; n = 569).Kuwunikaku sikunanene kusiyana kwakukulu mu matenda atsopano a T2, kusintha kwa matenda a T2 ndi kuchuluka kwa ubongo wa atrophy.Kusiyanasiyana kwa makina ojambulira a MRI ndi njira zopezera m'machitidwe azachipatala kumapangitsa kufananiza kwa zotsatira za MRI yaubongo kukhala zovuta.Kafukufuku wambiri padziko lonse lapansi awonetsa kuti mphamvu ya natalizumab EID ikufanana ndi mlingo wovomerezeka wa Q4W.3-7Biogen ikupitiriza kuwunika mphamvu, chitetezo ndi kulekerera kwa natalizumab EID kupyolera mu mayesero omwe akuyembekezeka NOVA (NCT03689972), ndipo posachedwapa yatumiza pempho la subcutaneous administration kwa olamulira.Ngati ivomerezedwa, Ipereka zosankha zambiri pakuwongolera kwa TYSABRI.
Malinga ndi kuwunika kwa Neuro-QoL (Quality of Life in Nervous System Diseases), chithandizo cha TYSABRI chimakhala ndi kusintha kwakukulu paumoyo wina kuposa Ocrevus® (ocrelizumab).Pakuwunika kwamagulu a odwala omwe amafananizidwa ndi TYSABRI kapena Ocrevus, zidawoneka kuti madera 9 mwa 12 a Neuro-QoL mwa odwala omwe amathandizidwa ndi TYSABRI adachita bwino (n = 144).4 mwa madera 12 adachita bwino kwambiri (n = 502)).Ponseponse, chiwongola dzanja chapachaka cha TYSABRI ndichokwera kuposa cha Ocrevus, ndipo kusiyana kwakukulu kumawonedwa muzinthu zitatu: chikoka chabwino ndi moyo wabwino, kukhutitsidwa ndi maudindo ndi zochitika zamagulu, komanso vuto la kugona.
Poyerekeza ndi odwala a MS omwe ali ndi zaka zosakwana 60 (n = 729), zotsatira zachipatala za odwala a MS opitirira zaka 60 (n = 286) zimasonyeza kuti m'magulu onse azaka zonse, PLEGRIDY ndi AVONEX angapereke chithandizo chothandizira.Deta ikuwonetsa kuti mayeso othamanga (PST) ndi mayeso a sensitivity (CST) a magulu awiriwa asintha pakadutsa chaka chimodzi.Kuonjezera apo, ambiri omwe adatenga nawo mbali m'magulu onse awiriwa sanabwererenso mkati mwa zaka ziwiri.
Deta yochokera mu kafukufuku wa Phase 1 ya BIIB091 imathandizira kupitiliza chithandizo cha MSBiogen, ndipo deta yochokera ku kafukufuku wa Phase 1 ya BIIB091 imaperekedwanso.BIIB091 ndi chosankha, chosinthika (chopanda covalent) choletsa molekyulu yapakamwa ya Bruton's tyrosine kinase (BTK) Agent.Detayo idayesa chitetezo, kulekerera, ma pharmacokinetics ndi pharmacodynamics a single and angapo akuchulukirachulukira pakamwa Mlingo mwa anthu akulu athanzi.Choletsa chosankha cha BTK chingakhale chopindulitsa kuchiza matenda a MS poletsa kuyambitsa ma cell a B ndi ma cell a myeloid popanda kuchepa kwa ma cell a chitetezo.
Chiwonetsero cha data pa ACTRIMS-ECTRIMS: Zindikirani: Zowonetsa zonse za MSVirtual2020 zizipezeka pa intaneti nthawi ya 8 AM Kum'mawa Lachisanu, Seputembara 11, 2020.
Poyerekeza ndi dimethyl fumarate mu EVOLVE-MS-2, kulolerana kwa GI kwa Diroximel fumarate kumagwirizana kwambiri ndi kufunika kwa moyo wabwino (Poster 0214)
Zotsatira za Diroximel fumarate pakusintha kwa voliyumu yaubongo komanso kukula kwa kulumala kwa akuluakulu omwe ali ndi EVOLVE-MS-1 relapsing-remitting multiple sclerosis (Poster P0205)
Chitetezo ndi mphamvu za odwala omwe amathandizidwa ndi dimethyl fumarate ndikutsatiridwa kwa zaka 13: zotsatira zomaliza za ENDORSE (platform FC02.05-Lamlungu, September 13th 1:48-2:00 US Eastern Time)
Zotsatira za radiology za odwala omwe ali ndi Mlingo wotalikirapo wa Natalizumab sizosiyana ndi Mlingo wanthawi yayitali mu MS PATHS (Poster P0360)
Zotsatira za Natalizumab pa Ubwino wa Moyo mu Gulu Lenileni la Multiple Sclerosis Odwala: Zotsatira za MS Pathway (Poster P1036)
Makhalidwe ndi zotsatira zachipatala za odwala okalamba a MS omwe ali ndi Peginterferon Beta-1a kapena intramuscular interferon Beta-1a pochiza MS pathway (Poster P0843)
Phunziro la Gawo 1 la BIIB091 (a Bruton's tyrosine kinase (BTK) inhibitor) mwa anthu akuluakulu athanzi: zotsatira zoyambira (poster P0186)
About VUMERITY® (Dilosemate Fumarate) VUMERITY ndi fumarate yapakamwa yokhala ndi mankhwala osiyana kwambiri ndi TECFIDERA® (Dimethyl Fumarate), yovomerezedwa ku United States kuti athe kuchiza multiple sclerosis mwa akuluakulu Mitundu yobwerezabwereza ya matendawa imaphatikizapo ma syndromes odzipatula, matenda obwera mobwerezabwereza ndi matenda achiwiri opita patsogolo.Pambuyo polowa m'thupi, VUMERITY imasinthidwa mwachangu kukhala monomethyl fumarate, metabolite yofanana ya dimethyl fumarate.
VUMERITY imatsutsana ndi odwala omwe ali ndi matupi awo sagwirizana ndi Diroximel fumarate, dimethyl fumarate kapena zina mwazothandizira za VUMERITY;ndi odwala omwe amatenga dimethyl fumarate.Zotsatira zoyipa za VUMERITY zimachokera ku data ya dimethyl fumarate (metabolite yogwira yofanana ndi VUMERITY), kuphatikizapo matupi awo sagwirizana ndi angioedema, kupita patsogolo kwa multifocal leukoencephalopathy, yomwe ndi ubongo wovuta wopeza mwayi Matenda a virus amakhudzana ndi imfa kapena matenda oopsa.Kulemala, kuchepa kwa chiwerengero cha lymphocyte m'chaka choyamba cha chithandizo, shingles ndi matenda ena aakulu, kuwonongeka kwa chiwindi ndi kuphulika.Zoyipa zoyipa zomwe zidapezeka pogwiritsa ntchito data kuchokera ku dimethyl fumarate (yomwe ili ndi metabolite yogwira yofanana ndi VUMERITY) inali kukomoka, kupweteka m'mimba, kutsekula m'mimba, ndi nseru.
Chonde dinani apa kuti mudziwe zambiri zachitetezo ndi chidziwitso chonse chamankhwala, kuphatikiza chidziwitso cha odwala cha VUMERITY ku United States.
About TECFIDERA® (dimethyl fumarate) TECFIDERA ndi njira yochizira kuyambiranso kwa multiple sclerosis (MS) mwa akulu.Ndiwo mankhwala omwe amaperekedwa kuti ayambirenso MS padziko lonse lapansi.Zatsimikiziridwa kuti zimachepetsa kubwereza kwa MS ndikuchepetsa.Imapita patsogolo pakulemala ndipo imakhudza kuchuluka kwa zotupa zaubongo za MS, ndikutsimikizira kuti chitetezo chamtundu wa odwala omwe abwereranso MS ndiabwino.TECFIDERA yavomerezedwa m'maiko / zigawo za 69 ndipo yathandizidwa kwa odwala 475,000, zomwe zikutanthauza zaka zopitirira 950,000 za odwala omwe amagwiritsa ntchito ndi kupereka TECFIDERA.Mwa awa, odwala 6,335 (14,241 odwala-zaka) adachokera ku mayesero azachipatala8.
TECFIDERA ndi yoletsedwa kwa odwala omwe sakugwirizana ndi dimethyl fumarate kapena chilichonse chothandizira cha TECFIDERA.Zotsatira zoyipa kwambiri ndi monga matupi awo sagwirizana ndi angioedema, komanso milandu yowonjezereka ya multifocal leukoencephalopathy (matenda osowa mwayi muubongo omwe amalumikizidwa ndi imfa kapena kulumala kwakukulu) adawonedwa mwa odwala a TECFIDERA omwe ali ndi nthawi yayitali ya lymphopenia, ngakhale kuti ntchito ya lymphopenia sikudziwika bwino. .Zotsatira zina zoyipa zimaphatikizapo kuchepa kwa chiwerengero cha lymphocyte m'chaka choyamba cha chithandizo, shingles ndi matenda ena aakulu, kuwonongeka kwa chiwindi ndi kuphulika.M'mayesero azachipatala, zochitika zoyipa zomwe zimagwirizanitsidwa ndi TECFIDERA zinali kukomoka, kupweteka m'mimba, kutsekula m'mimba ndi nseru.
Chonde dinani apa kuti mudziwe zambiri zokhudza chitetezo ndi zonse zokhudza mankhwala, kuphatikizapo zokhudza odwala za TECFIDERA ku United States, kapena pitani ku webusaiti ya malonda m'dziko lanu.
About TYSABRI® (natalizumab) TYSABRI ndi chithandizo chothandizira kubwezeretsanso multiple sclerosis (RMS), chomwe chitha kugwiritsidwa ntchito poyambiranso MS mwa akulu.Mayesero azachipatala atsimikizira kuti mankhwalawa amatha kuchedwetsa kupita patsogolo kwa kulumala kwa thupi ndikuchepetsa Kupanga zilonda zatsopano zaubongo ndikuchepetsa kubwereza.TYSABRI yavomerezedwa m'maiko / zigawo 80.Malinga ndi mayeso azachipatala komanso zomwe adalemba, TYSABRI yalandila chithandizo cha TYSABRI kwa anthu opitilira 213,000 padziko lonse lapansi, ndi zaka zopitilira 835,000 za odwala.9
TYSABRI imawonjezera chiwopsezo chakupita patsogolo kwa multifocal leukoencephalopathy (PML), matenda osowa mwayi a muubongo omwe amalumikizidwa ndi imfa kapena kulumala kwakukulu.Choopsa chomwe chimawonjezera chiopsezo cha PML ndi kukhalapo kwa ma anti-JC virus antibodies, kugwiritsa ntchito ma immunosuppressive agents ndi TYSABRI pochiza nthawi yayitali.Odwala omwe ali ndi zifukwa zitatu izi ali ndi chiopsezo chachikulu cha PML.Mukayamba ndikupitilira chithandizo ndi TYSABRI, madotolo akuyenera kuganizira ngati mapindu omwe akuyembekezeredwa a TYSABRI ndi okwanira kuthana ndi chiwopsezochi.
TYSABRI imawonjezeranso chiopsezo chokhala ndi encephalitis ndi meningitis yoyambitsidwa ndi kachilombo ka herpes simplex ndi varicella-zoster.Malinga ndi malipoti, odwala a MS omwe akulandira TYSABRI ali ndi milandu yowopsa, yoyika moyo komanso yakupha pambuyo pa msika.M'malo otsatsa malonda, palinso kuwonongeka kwakukulu kwa chiwindi, kuphatikizapo kulephera kwa chiwindi komwe kumafuna kuikidwa.Zoyipa zina zazikulu zomwe zidachitika mwa odwala omwe adalandira chithandizo cha TYSABRI zidaphatikizapo kukhudzidwa kwa hypersensitivity (monga matupi awo sagwirizana) komanso matenda, kuphatikiza matenda otengera mwayi ndi matenda ena atypical.
Chonde dinani apa kuti mumve zambiri zachitetezo, kuphatikiza machenjezo omwe ali m'bokosi, ndi zonse zomwe mungalembe, kuphatikiza malangizo amankhwala a US TYSABRI, kapena pitani patsamba lazogulitsa m'dziko lanu/chigawo chanu.
About PLEGRIDY® (pegylated interferon β-1a) PLEGRIDY ndi subcutaneous pegylated interferon, kamodzi pa milungu iwiri iliyonse, chifukwa cha mawonekedwe obwerezabwereza a multiple sclerosis (MS) mwa akuluakulu, omwe ndi ofala kwambiri a MS.Common mawonekedwe.PLEGRIDY pano ndiyovomerezeka m'maiko/magawo opitilira 60, kuphatikiza United States, Canada, Australia ndi Switzerland, ndi European Union yonse.Malinga ndi zomwe zalembedwa ndi dokotala, anthu pafupifupi 57,000 padziko lonse lapansi alandila chithandizo cha PLEGRIDY, ndi zaka zopitilira 107,000 za odwala.10Biogen ikupitilizabe kugwira ntchito kuti ipereke PLEGRIDY m'maiko / zigawo zina padziko lonse lapansi.
Kuchita bwino ndi chitetezo cha PLEGRIDY kumathandizidwa ndi imodzi mwamaphunziro ofunikira kwambiri, omwe adagwiritsa ntchito chithandizo cha interferon kwa odwala omwe ali ndi MS yobwerezabwereza.M'maphunziro azachipatala, zatsimikiziridwa kuti PLEGRIDY ikhoza kuchepetsa kwambiri kubwereza kwa MS, kuchepetsa kupitirira kwa kulemala ndi kuchepetsa chiwerengero cha kuvulala kwa ubongo mu MS.Nthawi yomweyo, zatsimikiziridwa kuti chitetezo cha odwala omwe abwereranso MS ndiabwino.Zotsatira zoyipa zomwe zanenedwa zimaphatikizapo mavuto a chiwindi, kuphatikiza kulephera kwa chiwindi ndi kuchuluka kwa michere ya chiwindi;kuvutika maganizo kapena maganizo ofuna kudzipha;kwambiri thupi lawo siligwirizana;mavuto a mtima, kuphatikizapo congestive mtima kulephera;matenda autoimmune;kuchepa kwa maselo oyera a magazi kapena mapulateleti;ndi khunyu.M'mayesero azachipatala, zovuta zodziwika bwino zomwe zimagwirizanitsidwa ndi PLEGRIDY zinali momwe jakisoni amachitira komanso zizindikiro zonga chimfine.Mndandanda wazovuta zomwe zachitika zitha kupezeka muzolemba zonse za PLEGRIDY kudziko lililonse lodziwika.
Chonde dinani apa kuti mumve zambiri zachitetezo komanso zambiri zatsatanetsatane, kuphatikiza malangizo amankhwala a US PLEGRIDY, kapena pitani patsamba lazogulitsa m'dziko/dera lanu.
Za AVONEX® (Interferon beta-1a) AVONEX idapangidwa kuti iyambitsenso MS, ndipo yavomerezedwa m'maiko opitilira 90.Malingana ndi deta ya mankhwala, anthu oposa 580,000 padziko lonse alandira chithandizo cha AVONEX, ndi zaka zoposa 2.6 miliyoni za odwala.11AVONEX idapangidwa kuti ikhale yochizira matenda obwera chifukwa cha multiple sclerosis (MS), kuphatikiza ma syndromes odzipatula, obwereranso-akuluakulu omwe ali ndi matenda ofatsa komanso matenda achiwiri opitilira patsogolo.
Malinga ndi malipoti, odwala omwe amalandira AVONEX amakhala ndi zizindikiro za kupsinjika maganizo, malingaliro ofuna kudzipha kapena psychosis, ndipo kuchuluka kwa milandu yodzipha kwawonjezeka.Odwala ochepa amafotokoza kuwonongeka kwakukulu kwa chiwindi, kuphatikizapo kulephera kwa chiwindi.Osowa ziwengo zanenedwa.Ngakhale beta interferon alibe mwachindunji mtima kawopsedwe, akuti palibe odwala ndi chiwopsezo chodziwika kuti anayamba congestive mtima kulephera, cardiomyopathy, ndi cardiomyopathy wa congestive mtima kulephera.Zomwe zachitika pambuyo pa malonda zikuwonetsa kuti kuchuluka kwa maselo amwazi am'magazi kumachepetsedwa.Malinga ndi malipoti, odwala omwe amagwiritsa ntchito AVONEX amakhala ndi khunyu, kuphatikiza omwe alibe mbiri ya khunyu.Matenda a autoimmune a ziwalo zingapo zomwe akulimbana nazo adanenedwa.Ndibwino kuti muzichita kawirikawiri magazi, hematology, chiwindi ntchito ndi chithokomiro mayesero ntchito nthawi zonse.
Chonde dinani apa kuti mudziwe zambiri zachitetezo komanso zambiri zatsatanetsatane, kuphatikiza malangizo amankhwala a AVONEX ku United States, kapena pitani patsamba lazogulitsa m'dziko lanu/chigawo chanu.
Za Biogen At Biogen, cholinga chathu ndi chodziwikiratu: ndife apainiya pantchito ya neuroscience.Biogen imapeza, imapanga ndikupereka njira zochiritsira zatsopano padziko lonse lapansi kwa anthu omwe akuvutika ndi matenda oopsa a minyewa ndi matenda a neurodegenerative ndi chithandizo chofananira.Biogen ndi imodzi mwamakampani akale kwambiri padziko lonse lapansi asayansi yazachilengedwe, yomwe idakhazikitsidwa mu 1978 ndi Charles Weissmann, Heinz Schaller, Kenneth Murray, ndi opambana Mphotho ya Nobel Walter Gilbert ndi Phillip Sharp.Masiku ano, Biogen ali ndi mbiri yotsogola yamankhwala ochizira matenda ambiri a sclerosis, adayambitsa chithandizo choyamba chovomerezeka chamsana, kugulitsa ma biosimilars apamwamba kwambiri a biologics, ndikuyang'ana kwambiri kupititsa patsogolo multiple sclerosis ndi neuroimmunology.Matenda a Alzheimer's ndi dementia, matenda a neuromuscular, kusokonezeka kwa kayendetsedwe kake, ophthalmology, immunology, matenda a neurocognitive, matenda owopsa a minyewa ndi ululu.
Tidzasindikiza pafupipafupi zomwe zingakhale zofunikira kwa osunga ndalama patsamba lathu la www.biogen.com.Kuti mudziwe zambiri, chonde pitani ku www.biogen.com ndipo mutitsatire pazama TV pa Twitter, LinkedIn, Facebook, YouTube.
Biogen Safe Harbour Nkhaniyi ili ndi ziganizo zoyang'ana kutsogolo, kuphatikizapo zonena za phindu lomwe lingakhalepo, chitetezo ndi mphamvu za VUMERITY, TECFIDERA, TYSABRI, PLEGIIDY ndi BIIB091 pansi pa makonzedwe otetezedwa a Private Securities Litigation Reform Act of 1995;Zotsatira za data yeniyeni;Phunziro la EVOLVE-MS-2, ENDORSE Phase 3 phunziro ndi zotsatira za kafukufuku wa BIIB091 Phase 1;chizindikiritso cha MS ndi chithandizo;dongosolo lathu lachitukuko chamankhwala a MS;Kukambitsirana koyenera, kugonjera ndi kuvomereza ndi Kukonzekera nthawi;kuthekera kwabizinesi yamalonda ya Biogen, kuphatikiza VUMERITY, TECFIDERA, TYSABRI, PLEGRIDY ndi BIIB091;ndi kuopsa ndi kusatsimikizika kokhudzana ndi chitukuko cha mankhwala ndi malonda.Mawu oyang'ana kutsogolo awa atha kugwiritsa ntchito mawu monga "chandamale", "kuyembekezera", "kukhulupirira", "ndingathe", "kuyerekeza", "kuyembekezera", "zoneneratu", "chandanda", "kulinga", "chingachitike" Kuti zindikirani."," "kukonzekera", "akhoza", "zotheka", "chifuniro", "chifuniro" ndi mawu ena ndi mawu omwe ali ndi matanthauzo ofanana.Kupanga mankhwala osokoneza bongo ndi malonda kumaphatikizapo chiopsezo chachikulu, ndipo chiwerengero chochepa chabe cha kafukufuku ndi ndondomeko zachitukuko zimatsogolera ku malonda a malonda Zotsatira za mayesero oyambirira achipatala sizingasonyeze zotsatira zonse kapena zotsatira za mayesero achipatala mochedwa kapena aakulu, komanso sangathe. amaonetsetsa kuti akuvomerezedwa ndi malamulo.Musadalire mopambanitsa pa mawu awa kapena deta yasayansi yoperekedwa.
Mawuwa akuphatikizapo zoopsa ndi kusatsimikizika, ndipo zingayambitse zotsatira zenizeni kukhala zosiyana kwambiri ndi zotsatira zomwe zikuwonetsedwa m'mawu oterowo, kuphatikizapo koma osati kokha ku zochitika za chitetezo choyipa ndi / kapena nkhawa zosayembekezereka zomwe zingayambitsidwe ndi deta ina kapena kusanthula;ndalama zosayembekezereka kapena kuchedwa Zowopsa;Nkhawa zosayembekezereka zingabwere chifukwa cha deta ina, kusanthula kapena zotsatira pa mayesero a zachipatala;Kulephera kuteteza ndi kulimbikitsa deta yathu, ufulu wazinthu zaluntha ndi umwini wina, ndi kusatsimikizika kokhudzana ndi zonena zaukadaulo ndi zovuta;Mabungwe owongolera angafunike zambiri kapena kufufuza kwina, kapena sangathe kuvomereza kapena kuchedwetsa kuvomereza kwa omwe tikufuna kugwiritsa ntchito mankhwala osokoneza bongo kapena kukulitsa zilembo zamalonda;kulephera kupeza chivomerezo cha malamulo m'madera ena;zonena za ngongole zamalonda;ngozi za mgwirizano wa chipani chachitatu;ndi Mliri wa COVID-19 womwe ukupitirirabe uli ndi zotsatira zachindunji kapena zosalunjika pabizinesi yathu, zotulukapo zogwirira ntchito komanso momwe chuma chikuyendera.Zambiri koma osati zonse zomwe zatchulidwa pamwambapa zingapangitse zotsatira zenizeni kukhala zosiyana ndi zomwe timayembekezera m'mawu aliwonse oyembekezera.Otsatsa malonda akuyenera kuganizira za chenjezoli komanso ziwopsezo zomwe tazipeza mu lipoti lathu laposachedwa kwambiri lapachaka kapena kotala ndi malipoti ena omwe timatumiza ku Securities and Exchange Commission.Mawu awa akuchokera pazikhulupiliro ndi zomwe tikuyembekezera ndipo zikungoyimira momwe zinthu zilili kuyambira tsiku lomwe nkhaniyi idatulutsidwa.Kaya chifukwa cha chidziwitso chatsopano, zomwe zikuchitika m'tsogolo kapena zifukwa zina, sitipanga udindo wosintha poyera ziganizo zilizonse zoyembekezera.
Mowry EM, Beheshtian A, Waubant E, etc. Ubwino wa moyo mu multiple sclerosis umagwirizana ndi kulemedwa kwa matenda ndi zizindikiro za kuyeza kwa ubongo.Neurology.2009;72(20):1760-1765.
Lanz M, Hahn HK, Hildebrandt H. Brain atrophy ndi kuwonongeka kwa chidziwitso mu multiple sclerosis: ndemanga [Zosinthidwa zosindikizidwa zimasindikizidwa mu J Neurol.2008 Feb;255(2):309-10].Journal of Neurology.2007;254 Zowonjezera 2: II43-II48.
Foley J, Xiong K, Hoyt T, ndi zina zotero. Mlingo wochepa wa serum neurofilament kwa odwala omwe ali ndi relapsing-remitting multiple sclerosis anasinthidwa kuchoka ku natalizumab kamodzi pa masabata a 4 kuti apite nthawi yayitali.AAN 2020;S10.009.
Butzkueven, Kappos L, Spelman T, etc. Odwala omwe adasinthira ku natalizumab kuti atenge nthawi yayitali kapena kusunga mlingo wanthawi yayitali analibe kusiyana kwakukulu pazotsatira zobwerezabwereza: kuyerekezera kogwira mtima kwa kuchuluka kwa odwala omwe ali mu pulogalamu ya TYSABRI.ECTRIMS 2019;P1033.
Yamout B, Sahraian MA, Ayoubi NE, ndi zina zotero. Mphamvu ndi chitetezo cha natalizumab chimaperekedwa pakapita nthawi.Mult Scler Relat Disord.2018;24:113-116 .
Zhovtis Ryerson L, Frohman TC, Foley J, etc. Kutalikitsa kwakanthawi kasamalidwe ka natalizumab mu multiple sclerosis.J Neurol Neurosurgery Psychiatry.2016; 87:885-889.
Bomprezzi R, PawateS.Kuchulukitsa kwanthawi yayitali kwa natalizumab: zaka 7 zodziwika m'malo awiri.Ther Adv Neurol Disord.2014;7: 227-231 .
Pofika pa Juni 30, 2020, kutengera zomwe zaphatikizidwa pambuyo pogulitsa kuchokera ku mayeso azachipatala okhudzana ndi mankhwala komanso kukhudzana ndi TECFIDERA.
Pofika pa Julayi 31, 2020, zophatikiza zogulitsa pambuyo pogulitsa kutengera zomwe adalemba komanso mayeso azachipatala a TYSABRI.
(Bloomberg) -SAP SE mtengo wamtengo wapatali unagwa mpaka 21%, kutsika kwakukulu kwa tsiku limodzi kuyambira 1999. Poyamba, kampani ya Walldorf inachepetsa chiwerengero cha ndalama za chaka chonse ndipo inanena kuti ikuyembekezera ndalama zatsopano.Zotsekedwa mpaka theka loyamba la 2021, kufunikira kwachepetsedwa.Poyesa Christian Klein, adakhala CEO yekhayo mu Epulo.Mliriwu uchedwetsa ndalama za SAP zamtambo, zogulitsa zonse komanso zopangira phindu kwa chaka chimodzi kapena ziwiri, makamaka monga momwe kampani yamapulogalamu idanenera Lamlungu.SAP inanena kuti ikuyembekeza kukula kochepa ndi phindu la phindu m'zaka ziwiri zikubwerazi, ndipo idzasuntha ndondomeko yake ya 2023 mpaka 2025. Klein adanena pamsonkhano wa msonkhano Lolemba kuti akuyembekeza kuti SAP inene m'mawu omwe maganizo apitalo "akuganiza kuti " kuti chuma chidzatsegulidwanso ndipo kutsekeka kwa anthu kudzachepa, zomwe zikupangitsa kuti pakhale kusintha kwapang'onopang'ono kwa malo ofunikira mgawo lachitatu ndi lachinayi. "Kampaniyo posachedwa idaneneratu kuti pofika chaka cha 2020, kutengera mitengo yosinthika, ndalama zosinthidwa zidzafika 27.2 biliyoni mpaka 27.8 biliyoni (32.2 biliyoni mpaka 32.9 biliyoni US), zomwe ndizotsika kuposa momwe zimayembekezeredwa ndikuwonjezeka mpaka 28,5 biliyoni kuchokera ku malangizo apitawa. ndi 27.8 biliyoni mayuro.Euro.SAP inanenanso kuti bizinesi yake ya Concur sidzapindulanso ndi ndalama zokhudzana ndi kuyenda chaka chino.Katswiri wa OddoBHF Nicholas David adalemba mu lipoti kuti ndizovuta kupeza zotsatira zabwino kuchokera pazotsatira News.Zoyembekeza za msika pazofuna zapakati pazaka ndi / zimachita mantha, koma zilakolako zatsopano ndizotsika poyerekeza ndi zomwe zikuyembekezeka. ”Qualtrics IPOSAP yati gawo lake la mapulogalamu a Qualtrics lili pamlingo wapamwamba kwambiri.Idalengeza mu Julayi kuti idaganiza zogula kampaniyo pamtengo wapamwamba ndipo idawonekera ku US pasanathe zaka ziwiri.Uku kunali kusintha kosayembekezereka ndipo kunawonetsa kusintha kwabwino pansi pa utsogoleri wa Klein."Tapita patsogolo kwambiri pokonzekera Qualtrics 'IPO," Chief Financial Officer Luka Mucic adatero pafoni Lolemba."Kuchita bwino kwambiri kotala kotala kudzakhazikitsa maziko okulirapo chaka chamawa."Malingaliro atsopano omwe adasinthidwa mumtambo akuyembekezeka kukwera kuchoka pa 8 biliyoni kufika pa 8.2 biliyoni mu 2020, kutsika poyerekeza ndi zomwe zidalipo kale za 8.3 biliyoni mpaka 8.7 biliyoni.Phindu la Euro Euro yogwira ntchito chaka chino lidzakhala pakati pa 8.1 biliyoni ya Euro ndi 8.5 biliyoni ya Euro, yomwe ili yotsika kuposa 8,7 biliyoni ya Euro yomwe ikuyembekezeredwa.SAP yawonjezera cholinga chake chapakatikati kuti ipitirire 36 biliyoni mu ndalama zonse pofika chaka cha 2025 ndipo idzafika 35 biliyoni pofika 2023.Phindu lopanda IFRS lachitatu kotala lachitatu latsika ndi 12% pachaka mpaka ma euro 2.07 biliyoni.Poyerekeza ndi mayuro biliyoni 2.15 kuyembekezera ndi akatswiri kafukufuku Bloomberg, ndalama pa nthawi inagwa ndi 4% mpaka 6.54 biliyoni mayuro, pamene pafupifupi wowunika Maneneratu anali 6.89 biliyoni mayuro., SAP CEO kudzera PandemicU.K.CMA imapanga njira yakeyake ndikuyamba kufufuza kosagwirizana ndi Sinch, gawo la SAP DealSAP limaperekedwa kwa JP Morgan Stanley, ndipo JP Morgan amayendetsa Qualtrics IPO (zosintha zamasheya, zochitika zina).Chonde pitani ku Bloomberg.com kuti mutichezere ndikulembetsa tsopano.Khalani otsogola ngati gwero lodalirika la nkhani zamabizinesi.©2020 Bloomberg LP
Wowerengera ndalama ku San Francisco adakambirana za kufunikira kwa kayendetsedwe ka Biden pakuyika ndalama pazokambirana zilizonse ndi makasitomala.
Ogwiritsa ntchito omwe sanayikepo oda pa nsanja iliyonse ya JD atha kulandira makuponi ochotsera!Ndi khadi lanu la Visa, dinani kuti mulipire pa JD.com koyamba ndikusangalala ndi kuchotsera!
Wopambana mphoto ya Nobel pazachuma, pulofesa waku Yale University, Robert Shiller, adalimbikitsa osunga ndalama kuti asamale ndi msika wa blockbuster pamsika waposachedwa mu New York Times.
Kampaniyo idati Lee Kun-hee, yemwe adapanga Samsung Electronics kukhala chimphona chapadziko lonse lapansi pamafoni, ma semiconductors ndi ma TV, adamwalira Lamlungu atagonekedwa m'chipatala kwa zaka zopitilira zisanu ndi chimodzi ndi vuto la mtima Lamlungu.Lee ali ndi zaka 78 chaka chino.Adapanga Gulu la Samsung kukhala gulu lalikulu kwambiri ku South Korea ndipo adakhala munthu wolemera kwambiri ku South Korea.Jeong Sun-, mkulu wa kampani yofufuza za kampani ya Chaebul.com, anati: “Kukwera modabwitsa kwa Lee ku Korea komanso mmene dziko la South Korea limagwirizanirana ndi kudalirana kwa mayiko n’zophiphiritsa kwambiri moti anthu ambiri aku Korea adzakumbukira imfa yake.
Zaka zinayi pambuyo pa kugwa kwa BHS, kodi makampani owerengera ndalama omwe akhala akudzudzulidwa chifukwa cholephera kupeza mavuto asintha?
Malinga ndi malipoti a CNBC, Jack Ma, woyambitsa Alibaba Group Holdings Limited (NYSE: BABA), adati Loweruka kuti zopereka zapawiri za Ant Group (IPOs) ku Shanghai ndi Hong Kong zikhala kampani yayikulu kwambiri padziko lonse lapansi.Zomwe zinachitika: CNBC inanena kuti IPO mtengo unali Lachisanu usiku, koma Jack Ma sanaulule nambala yeniyeni, yomwe idzalengezedwa sabata yamawa.Mbiri ya anthu - yatsimikiziridwa kunja kwa New York City."Ma Yun adatero ku Shanghai Bund Summit.Bilionea waku China adatcha nkhaniyi kuti "chozizwitsa."Iye anati: “Sitinayerekeze kuganizapo zaka zisanu kapena zitatu zapitazo."Ma Yun adapemphanso kuti pakhale kusintha kwa mabanki ndikukhazikitsa njira yatsopano yophatikizira mabanki padziko lonse lapansi.Chifukwa chiyani kuli kofunikira: Zopereka zoyamba zamakampani zothandizidwa ndi Alibaba zitha kupanga ndalama pafupifupi biliyoni imodzi, zomwe zingapangitse Saudi Aramco Kupereka koyambirira kwapadziko lonse lapansi kwa US $ 29.4 biliyoni.Zogulitsa za Aramco zomwe zidatulutsidwa mu Disembala 2019 zidagonjetsa Alibaba ndikupambana korona wamkulu wa IPO.Malinga ndi malipoti, thumba lachuma la Singapore la GIC Private Limited litha kulembedwa pamndandandawu.Ndalamazo zimaposa US $ 1 biliyoni.Malinga ndi a Reuters, a Temasek waku Singapore, yemwe analipo kale wabizinesi wa Ant, wawonetsanso chidwi ndi katunduyo.Mtengo wamtengo: Mtengo wamasheya wa Alibaba udatseka pafupifupi 1.2% Lachisanu mpaka US $ 309.92.Inakwera ndi 0.11% panthawi yamalonda atatha maola angapo.Zina zambiri kuchokera kwa Ben Singa *Dinani apa kuti muwone malonda a Ben Singa * Quibi akugwa-lingaliro ili silili lolimba mokwanira, utsogoleri wa Benzinga.com (C) unanena mu 2020: "Kapena "Nthawi" ikusowa.Benzinga sapereka upangiri wandalama.maumwini onse ndi otetezedwa.
Perekani mwamsanga kuthandiza bungwe la UN othawa kwawo, kuti othawa kwawo apeze zida zadzidzidzi kuti athe kuthana ndi nyengo yamvula ndikuwapulumutsa ku tsoka!
Ndikosavuta kugula masheya, koma ndizovuta kugula masheya oyenera popanda njira yoyesedwa nthawi.Ndiye, ndi stock iti yabwino kwambiri yomwe mungagule kapena kuyika pamndandanda wowonera pano?
Tsogolo linagwa kwambiri.Msika wogulitsa ukhoza kupita ndi atsogoleri monga Microsoft ndi Tesla.Chisankho chikuyandikira komanso milandu ya coronavirus ikukwera, iyi inali sabata yopeza ndalama zambiri.
Harry Markopolos (Harry Markopolos), yemwe kale anali katswiri wopeza ndalama yemwe adatembenukira kwa wofufuza wodziimira payekha wachinyengo, adapeza $ 65 biliyoni Bernie Madoff Ponzi scheme, koma adanyalanyazidwa ndi SEC Kwa zaka zisanu ndi zinayi.Monga wotsutsa mosapita m'mbali kwa oyang'anira aku US, Harry tsopano akuwona gawo la auditing ndi makampani a inshuwaransi ngati mlandu waukulu wotsatira wachinyengo wazachuma womwe udzawululidwe.
Ndalama zatsopano zochotsera msonkho pa intaneti za Hang Seng zimapereka zaka 10 za ndalama zowonjezera zokhazikika ndikutsimikizira 1.73% -2% ya kukonzanso ndalama zamkati.Zimangotenga mphindi 10 kuti mulembetse inshuwaransi pa intaneti ndikuchitapo kanthu nthawi yomweyo.
Anthu atatu odziwa bwino nkhaniyi adanena kuti wosonkhanitsa wamkulu wa iPhone, Foxconn wa ku Taiwan, wakhazikitsa gulu logwira ntchito kuti athetse chikoka cha makampani opanga zamagetsi ku China Luxshare.Kampaniyo ikukhulupirira kuti Luxshare ndiye omwe amalamulira.chiwopsezo chachikulu.Mmodzi mwa magwero adanena kuti ntchitoyi idakhazikitsidwa ndi woyambitsa Foxconn Guo Taiming ndipo cholinga chake ndi Luxshare <002475.SZ> yomwe ili ku Dongguan.Kampaniyi sidziwika padziko lonse lapansi, koma ikuyembekezeka kukhala kampani yoyamba kusonkhana ku China.Likulu la iPhone-mpaka pano, turf ikadali yolamulidwa ndi opanga aku Taiwan.Gwero linanena kuti gulu logwira ntchito linakhazikitsidwa chaka chatha ndipo lakhala likufufuza zaukadaulo wa Luxshare, mapulani okulitsa, njira zolembera anthu ntchito komanso ngati kampaniyo (panopa ndi 5% yokha ya ndalama za Foxconn) imathandizidwa ndi bungwe lililonse la boma la China.
Zopeza zazikulu za sabata ino komanso lipoti lazachuma lazachuma zidzatulutsidwa kumapeto kwa sabata ino, ndipo masheya ambiri a FAANG amanenedwa pambuyo potseka Lachinayi.
Lipoti lamalipiro la gawo lachitatu la AMD (AMD) liyenera kutulutsidwa pambuyo pa kutseka Lachiwiri, yomwe ndi nthawi yosangalatsa kwa makampani opanga ma semiconductor.The Wall Street Journal inanena kuti AMD (AMD) ikukonzekera kukulitsa bizinesi yake mwachangu kudzera muzopeza (XLNX) (XLNX).Nthawi yomweyo, mpikisano wake wamkulu (INTC) wakhala akugwira ntchito molimbika kuti apitilize kupanga matekinoloje apamwamba opangira ma semiconductors apamwamba kwambiri.
Gulani m'masitolo akuluakulu a mafashoni pa intaneti ndikukhala ndi khadi la Visa kuti musangalale ndi kuchotsera 20%!Dziwani zambiri zaposachedwa kwambiri za Luisa Via Roma ndi Taylor tsopano!
Katswiri wa CFRA, Garrett Nelson, poyankhulana ndi Yahoo Finance Lachisanu kuti ngati Joe Biden (Joe Biden) atapambana pazisankho zapurezidenti, Tesla (NASDAQ: TSLA) ndiye adzapambana kwambiri.Zomwe zidachitika: Nielsen adati Tesla adzakhala "m'modzi mwamakampani akuluakulu" opambana chifukwa kampaniyo ndi "galimoto yamagetsi yamagetsi".Katswiriyu adati boma la Biden lipereka ndalama zothandizira magalimoto amagetsi.Ofufuza a CFRA adanenanso kuti a Biden akufuna "kukulitsa ndalama zambiri zamisonkho yamagalimoto amagetsi" komanso "kumanga kwakukulu kwa malo opangira magalimoto amagetsi."Nielsen anati: “Mukuganiza zoonjezera kuchuluka kwa malo ochapira magalimoto amagetsi pafupifupi ka 20.Zidzathandizadi kutchuka kwa magalimoto amagetsi."Zofunika: Pamkangano womaliza wapurezidenti ku Tennessee sabata yatha, a Biden adati boma lake likhazikitsa malo opangira magalimoto 50,000 pamsewu waukulu.Otsatirawo akuti malo opangira izi atsogolera United States kukhala ndi "tsogolo".Wachiwiri kwa Purezidenti amakhulupirira kuti masomphenya ake a magalimoto amagetsi amatha kuthana ndi kusintha kwa nyengo ndikupanga "ntchito zatsopano zolipira kwambiri."Kampani yotsogoleredwa ndi Elon Musk inalengeza gawo lachitatu sabata yatha Ndalamazo zinali US $ 8.77 biliyoni, kuwonjezeka kwa 39% pachaka;Kuchita kwamitengo: Magawo a Tesla adatsika pafupifupi 1.2% Lachisanu mpaka US $ 420.63.Ngati Joe Biden apambana TSLA DateFirmActionKuchokera aposachedwa kwambiri pazisankho za Okutobala 2020 Morgan Stanley amasunga zolemera zofanana (Ogasiti 2020) Canaccord Genuity imasunga zogulitsa zomwe zidachitika mu Okutobala 2020 ndipo imachita bwino kwambiri msika wokulirapo.Onani zambiri zowunikira za TSLA.Onani malingaliro aposachedwa kwambiri * Kuwunika kwaposachedwa kwa Benza pakuchitapo * Rives Musk adati ntchito zobwereketsa mwezi uliwonse zizipezeka chaka chamawa.Jim Kramer adanena kuti Jim Tesla ndi "wopenga" mu 2020 (C) Benzinga.com, zomwe ndi "zolakwika" Benzinga sapereka uphungu wa ndalama.Maumwini onse ndi otetezedwa.
Kodi ndi njira iti yoyendetsera ndalama yomwe yakhala ikuyesa nthawi?Kukula ndalama.Akatswiri a Wall Street amakhulupirira kuti masheya omwe ali ndi chiyembekezo chakukula mopitilira muyeso akuwonetsa zina mwazinthu zofunikira kwambiri.Kuthekera kwakukula kumeneku sikungatheke, ndipo mayinawa adzapeza phindu lalikulu mu 2020 ndi kupitirira.Izi zati, kunena pang'ono, kupeza masheya omwe amagwera m'gululi kungakhale kovuta.Ofufuza amakhulupirira kuti njira imodzi ndiyo kubwerera m'mbuyo, kuyang'ana chithunzithunzi chachikulu, ndikuyang'ana makampani omwe ali ndi kukula kwa nthawi yaitali malinga ndi zomwe achita bwino chaka ndi chaka.Pokumbukira izi, tidagwiritsa ntchito nkhokwe ya TipRanks kuti tidziwe masheya atatu omwe akukula omwe adavoteledwa kwambiri ndi akatswiri.Masheya onse atatu adakula kwambiri mu 2020 ndipo ali okonzeka kupitiliza kukwera.Pennsylvania National Game Company (PENN) Choyamba, ndife eni ake a Pennsylvania National Game Company, omwe ndi eni ake komanso amayendetsa malo ochitira masewera ndi mpikisano komanso mabizinesi ofikira masewera apakanema ku United States.Dzinali lakwera 146% pachaka mpaka pano, koma akatswiri ena a Wall Street amakhulupirira kuti mafuta akadali ochuluka mu thanki.PENN posachedwapa yalengeza zotsatira zake za kotala lachitatu pasadakhale, zomwe zidaposa zomwe zikuyembekezeka.Kampaniyo ikuyembekeza kuti phindu la kotalali liwonjezeke ndi zopitilira 900, ndipo EBITDAR yosinthidwa idzakula ndi 5% pachaka, ngakhale ndalama zitatsika ndi 10% pachaka.Katswiri wa nyenyezi zisanu a Joseph Greff adauza makasitomala kuti "JP Morgan Chase" adati: "Kubwezeretsa kwamakampani amasewera mu Meyi / June kudapitilira mpaka gawo lachitatu, ndipo ndalama zidali bwino kuposa momwe amayembekezera.Kufuna kukaponderezedwa Pambuyo pobwerera mwakale, komanso popeza kuti magwiridwe antchito a COVID apita patsogolo, ndalama zogwirira ntchito sizinakwere / sizinakwere.M'mbuyomu tinkaganiza kuti chiwonjezeko chikuchepa. ”Atanena izi, Greif adavomereza kuti poganizira zamtengo wapatali wamtengo wapatali, akatswiri ena adasiya kutsika kumbuyo ".Komabe, amakhulupirirabe kuti "mtengo ndi chothandizira mtsogolo".Akatswiri ofufuza anati: “…Pali chipwirikiti pamalingaliro amalonda.Timakhulupirira kuti izi ndi zathanzi kwa masheya ndipo ndizofunikira kuti masheya apitirire kukwera;timakhulupirira kuti osunga ndalama zamasewera achikhalidwe sanapezedwe kotheratu.Timakhulupilira kuti osunga ndalama amakayikira za kuthekera kwa PENN kupikisana ndi DraftKings, Fanduel, Caesars Entertainment, MGM/GVC, ndi zina zambiri. PENN wachibale wa pepala kukula akhoza kulipira ndalama zopezera makasitomala oyambirira kubetcha masewera, koma tikukhulupirira , Poganizira kuti posachedwapa equity. kusonkhanitsa ndalama kwakweza $950 miliyoni, chiwopsezo cha mpikisanowu chachepetsedwa kwambiri. ”Chofunika koposa, PENN yakhazikitsa posachedwa pulogalamu yakubetcha ya Barstool Sports ku Pennsylvania.Greff adatcha kutulutsidwa koyambiriraku "kolimbikitsa malinga ndi kuchuluka kwa ndalama komanso kugulitsa," ndipo zidatsimikizira "kuthekera kwa njira yapadera yopezera gawo."Kuphatikiza apo, kukwera kwa Barstool Sportsbook kukukulirakulira.Chofunika kwambiri, Greff amakhulupirira kuti masewera omwe ali nawo panopa kubetcha ndi iGaming chilengedwe chikufanana ndi kukwera kwa misika yachigawo mu 1990s, pamene mayiko omwe ali ndi vuto la bajeti adatembenukira kuzinthu zatsopano zopezera ndalama, monga masewera a mtsinje kuti athandize kuphimba bajeti zawo.kuchepa.Pankhani imeneyi, katswiriyu anati: “Tikukhulupirira kuti dziko lililonse lili ndi ziyembekezo zofanana ndi za USB ndi iGaming, ndipo PENN idzakhala m’modzi mwa opambana.Timakonda masewero otengera masewera / masewera kubetcha / iGaming ku US ndikuwona malo oti akule..”Chabwino, sizodabwitsa kuti Manda adakhalabe ndi Bulls.Kuwonjezera pa kupereka "kulemera kwambiri", adayikanso mtengo wamtengo wapatali wa $ 83 pa katundu.Ngati cholinga ichi chikakwaniritsidwa m'miyezi khumi ndi iwiri yotsatira, osunga ndalama atha kubweza 32%.(Kuti muwonere mbiri ya Greif, dinani apa.) Kodi Wall Street yonse ikuti chiyani?Zogula zisanu ndi zinayi, zogwira katatu ndi kugulitsa kumodzi zidaperekedwa m'miyezi itatu yapitayi.Zotsatira zake, PENN idalandira "kugula kwapakatikati" mgwirizano.Malingana ndi mtengo wamtengo wapatali wa $ 76.77, mtengo wamtengo wapatali ukhoza kukwera ndi 22% chaka chamawa.(Onani Penn National Gaming stock analysis on TipRanks.) Redfin (RDFN) Redfin inayamba ndi malo ofufuzira ozikidwa pa mapu ndipo inakulitsa malonda ake kuti apange masewera a banja, zoyambira ndi kuchititsa njira mofulumira komanso zosavuta.Ku Wall Street, anthu ena amaganiza kuti dzinali silimangonena za kuchuluka kwa COVID, ndipo kupindula kwake kwazaka 113% ndi chiyambi chabe.Ngakhale RDFN idachotsa zolosera zamphamvu zagawo lachitatu, osunga ndalama adakhumudwitsidwa ndi zotsatira zake.Jake Fuller wa BTIG adanenanso kuti mtengo wa masheya ukhoza kutsika chifukwa "zoyembekeza ndizokwera komanso kuchuluka kwa ndalama zomwe amapeza kumakhala pafupifupi 2%" ndipo "ochita nawo ndalama mwachangu amakonda kupereka mphotho yoyendetsedwa ndi voliyumu, pomwe RDFN imatsalira kumbuyo kwa chiyembekezochi."Fuller akukhulupirira kuti RDFN sicholinga cha anthu ambiri, zomwe zikuwonetsa kuti osunga ndalama mwina sanawone kuwulula zomwe amapeza.Komabe, akuganiza kuti Wall Street ikhoza kuphonya mbali yofunika kwambiri ya chithunzicho.Katswiri wa nyenyezi zisanu adati: "Chomwe sichinganyalanyazidwe apa ndikuti RDFN yawonjezera chiwongola dzanja popanda kukhudza kwambiri kutembenuka, zomwe zithandizira kwambiri kuwona phindu lalikulu la RDFN."Kuti izi zitheke, adzalandira Phindu lalikulu la 2021 likuyembekezeka kuwonjezeka ndi 47%.Kuyang'ana mwatsatanetsatane mwatsatanetsatane wa kotalali, RDFN idafunikira kwambiri ndipo ndalama zantchito zogulitsa nyumba zidakula 36% pachaka.Kuchuluka kwa masamba awebusayiti ndi kuchuluka kwazomwe zimachitika mwezi ndi mwezi.Komabe, ziyenera kukumbukiridwa kuti kukweza kumayendetsedwa ndi ndalama zamalonda aliwonse.Fuller adati: "Izi ndizofunikira chifukwa zikuwonetsa kuti chiwongola dzanja chomwe chikuyembekezeka chidzathandizira.""Malinga ndi ziwerengero zathu, ndalama zogulira nyumba kuchokera ku 1.68% ya GTV mgawo lachitatu la 2019 ndipo gawo lachiwiri la 2020 1.78% zidakwera kufika pa 1.85% mgawo lachitatu la 2020. anthu ambiri mderali.Ngakhale kuli kovuta kuwunika kulimbikira kwa kufunidwa, kukwera kwamitengo ndi mapindu abwinoko ayenera kukhala okhazikika "Fowler adathirira ndemanga.Mogwirizana ndi chiyembekezo chake, Fuller adathandizira ng'ombe zamphongo, kubwereza mtengo wogula ndi mtengo wamtengo wapatali wa $ 65.Cholinga ichi chikuwonetsa chidaliro chake mu kuthekera kwa RDFN kukwera ndi 45% chaka chamawa.(Kuti muwone mbiri ya Fuller, dinani apa.) Posamukira kumadera ena a Wall Street, malingaliro adagawanika kwambiri.M'miyezi itatu yapitayi, 6 kugula, 5 kusunga ndi 1 kugulitsa zinaperekedwa.Malinga ndi Wall Street, RDFN ndi kugula kwapakatikati.Mtengo wapakati wa $ 50 umatanthauza 11% mokweza.(Onani Redfin stock analysis on TipRanks) Vertiv Holdings (VRT) Monga m'modzi mwa otsogola padziko lonse lapansi a hardware, mapulogalamu ndi opereka chithandizo, Vertiv Holdings yathandizira kulimbikitsa msika wolumikizana wamagetsi a digito, momwe zinthu zambiri zofunika kwambiri. kufalitsidwa, kusanthula, kukonzedwa ndi kusungidwa.Wall Street idati yakwera 71% mpaka pano chaka chino, ndipo pakhoza kukhala zopindulitsa zambiri.Ngakhale mtengo wamtengo wapatali ukukwera kwambiri, wofufuza wa Wolfe Research Nigel Coe amakhulupirirabe kuti chiopsezo / mphotho ndi yabwino.Iye anafotokoza kuti: "Timakhulupirira kuti Vertiv ndi mitundu yosowa yomwe ingakope anthu ambiri omwe amagulitsa ndalama: kampani yokulirapo yapakatikati yomwe ingapereke phindu lokongola pamtengo wotsika ndipo ili pansi pa udindo wa gulu lapamwamba."Zikafika ku VRT Panjira yopita kukukula, misika yake yayikulu ndi malo opangira ma data ndi matelefoni.Malo awa ndi malo omwe Coe akuyembekeza kukwaniritsa kukula mu 2020 ndi 2021, komanso kuipa kwa nthawi yaitali komwe kumadza chifukwa cha kuwonjezeka kosalekeza kwa mphamvu ya deta ndi kukweza kwa 5G.Kuphatikiza apo, motsogozedwa ndi zoyesayesa zosunga ndalama zokhazikika mosadukiza kudzera pakukweza kosiyanasiyana kwa magwiridwe antchito ndikuchepetsa zovuta zamagulu, oyang'anira adalongosola njira yowonjezerera phindu ku 500 maziko."Iyi ndi script yomwe idatumizidwa bwino ndi wapampando wamkulu David Cote panthawi yomwe anali ku Honeywell, zomwe zimatitsimikizira kuti zolemba zofananira zitha kutumizidwa ku Vertiv," adatero Cohen.Ndizofunikira kudziwa kuti VRT idachoka mgawo lachiwiri la 2020, ndi ngongole yokwana pafupifupi US $ 2.1 biliyoni ndi ngongole yonse / EBITDA idafika nthawi 4.2.Ngakhale kumapeto kwamtunduwu, Coe amakhulupirira kuti pepala loyenera likhoza kutsika mwachangu.Kuti izi zitheke, akuganiza kuti pofika chaka cha 2023 chiŵerengero cha ngongole / EBITDA ndi kawiri, ndiye kuti ndalama zotsalira zidzafika 1 biliyoni US dollars."Pakadali pano sitikuganiza kuti Vertiv ndi nkhani yodziwika bwino yoperekera ndalama, koma izi zitha kuchitika mkati mwa 2022/23-titha kuwona ntchito zogulira zinthu kuti ziwonjezere kuthekera kwake pantchito yogawa magetsi komanso gawo la DCIM.Zosankha zina zotheka ndi kuthetsedwa kwa zilolezo zandalama (izi zikuwonetsedwa pano pakuwerengera kwathu kocheperako) komanso momwe magawo amagawidwira, zomwe zidzakulitsa kuthekera kwa umwini wa mabungwe.Sitinganyalanyazenso mfundo yakuti zida zambiri zazikulu zamagetsi Kukula kwa mgwirizano wokhazikitsidwa ndi omwe akutenga nawo gawo pamsika, omwe atenga nawo mbali sali ofunikira pa data center. "Chilichonse chomwe VRT idachita chidakopa Coe kuti abwereze kuwongolera kwake.Pomwe amayitanitsa zosankha, adakhazikitsa mtengo wa $ 23, kutanthauza kuti 22% ikhoza kukhala yokwera.(Kuti muwone mbiri ya Coe, dinani apa) Kodi akatswiri ena amavomereza?ali.M'miyezi itatu yapitayi, mavoti 4 okha "ogula" omwe adasindikizidwa.Chifukwa chake, uthengawu ndi womveka: VRT ndiyogula mwamphamvu.Popeza kuti mtengo wamtengo wapatali ndi $ 20.75, mtengo wamtengo wapatali ukhoza kukwera ndi 10% chaka chamawa.(Onani kusanthula kwamasheya a Vertiv Holdings pa TipRanks) Chodzikanira: Malingaliro omwe afotokozedwa m'nkhaniyi ndi a akatswiri okhawo.Zomwe zili m'munsimu ndizongowona zokha.Musanapange ndalama zilizonse, ndikofunikira kudzifufuza nokha.
Microsoft, Apple, Alphabet, Facebook, Amazon, AMD, Caterpillar, Comcast, GE, Ford, Pfixer, Visa, UPS, Exxon Mobil, Twitter ndi makampani ena adanenanso zotsatira zawo zachitatu.
Pulatifomu yatsopano yogawana ma SME aku Hong Kong- "HSBC Airport" imakulumikizani ku zambiri zamabizinesi ndi zochitika zosiyanasiyana
Mu sabata yotsiriza pa October 22, chiwongoladzanja cha chiwongoladzanja chinatsika kwambiri.Zikuyembekezeka kuti COVID-19 ndi ndale zaku America zipitiliza kukhala ndi zotsatira sabata ino.
Trifecta Stocks idzazindikiritsa masheya a bearish Lachitatu lililonse, ndipo pakhoza kukhala mwayi wosangalatsa wopezera ndalama pakanthawi kochepa.Pogwiritsa ntchito kusanthula kwaukadaulo kwa ma chart awa, ndipo ngati kuli koyenera, kutengera zochita zaposachedwa za TheStreet's Quant Ratings ndi mavoti, tachotsa mayina asanuwo.Ngakhale sitingaganizire kusanthula kofunikira, tikukhulupirira kuti nkhaniyi ipatsa osunga ndalama omwe ali ndi chidwi ndi masheya ndi poyambira bwino kuti awonjezere homuweki pa dzinalo.
Pambuyo pa zaka zogwira ntchito pa gasi wa shale waku America, Chevron ikubetcha tsogolo lake la gasi lachilengedwe kudera losakhazikika ku Middle East, ndipo akatswiri amagetsi akhala osamala kwanthawi yayitali.Kusuntha kwakukulu kwa kampaniyo Michael Wirth kumathandizidwa ndi kubetcha kuti Middle East ikulowa m'nthawi ya chiyanjanitso, zomwe zipangitsa kukhala chisankho chabwino kwambiri pakuchotsa gasi, chifukwa akuyembekezeka kukhala otsika mtengo kuposa mafuta otsika mtengo komanso oyera.Kufuna kudzaposa mafuta.Njira yatsopanoyi ndi yakuti kampaniyo imalimbikitsa malonda atsopano a gasi ku Egypt, Israel, ndi Qatar, ndikuchepetsa ndalama zomwe zimagwiritsidwa ntchito pofufuza shale ku United States.