Zipangizo ndi mamolekyu ambirimbiri ochiritsira, kufufuza, ndi kafukufuku wa nano-scale apangidwa kuti azigwira ntchito mkati mwa maselo amoyo.Ngakhale kuti tinthu tating'onoting'ono timeneti timagwira ntchito bwino pa zomwe amachita, nthawi zambiri zimakhala zovuta kuzipereka zomwe zimakhala zovuta kuzigwiritsa ntchito pazinthu zothandiza.Nthawi zambiri, zotengera zamtundu wina zimagwiritsidwa ntchito kunyamula tinthu ting'onoting'ono m'maselo kapena nembanemba ya cell imasweka kuti olowa alowe. Mwakutero, njirazi zimavulaza ma cell kapena sizili bwino pakuperekera katundu wawo nthawi zonse, ndipo zimatha zovuta kupanga makina.

Tsopano, gulu la ogwira nawo ntchito ochokera ku Korea University ndi Okinawa Institute of Science and Technology Graduate University ku Japan apanga njira yatsopano yopezera tinthu tating'onoting'ono ndi mankhwala, kuphatikiza mapuloteni, DNA, ndi mankhwala, kulowa mkati mwa maselo osawononga kwambiri. .

Njira yatsopanoyi imadalira kupanga ma spiral vortexs mozungulira ma cell omwe amapunduka kwakanthawi kwa nembanemba zam'manja kuti zinthu zilowe. Mikandayi imawoneka kuti imayambiranso kukhala momwe idayambira pompopompo ikatha.Zonsezi zimachitika mu gawo limodzi ndipo sizifuna zovuta za biochemistry, magalimoto operekera nano, kapena kuwonongeka kosatha kwa ma cell omwe akukhudzidwa.

Chipangizo chomwe chimapangidwira ntchitoyi, chotchedwa spiral hydroporator, chimatha kutulutsa ma nanoparticles agolide, ma mesoporous silica nanoparticles, dextran, ndi mRNA m'maselo osiyanasiyana mkati mwa mphindi imodzi pakuchita bwino mpaka 96% ndikupulumuka kwa ma cell mpaka 94. %.Zonsezi pamlingo wodabwitsa wa maselo pafupifupi miliyoni imodzi pamphindi imodzi komanso kuchokera ku chipangizo chotsika mtengo kupanga komanso chosavuta kuchigwiritsa ntchito.

"Njira zamakono zili ndi zofooka zambiri, kuphatikizapo zovuta zowonongeka, mtengo, kuchepa kwachangu komanso cytotoxicity," adatero Pulofesa Aram Chung wa ku Sukulu ya Biomedical Engineering ku Korea University, phunziroli likutsogolera."Cholinga chathu chinali kugwiritsa ntchito ma microfluidics, pomwe tidagwiritsa ntchito mafunde ang'onoang'ono amadzi, kuti tipeze njira yatsopano yothetsera kubereka kwapakhungu ... nanomaterial - kutuluka kwa malekezero ena awiri.Ntchito yonseyi imatenga mphindi imodzi yokha. ”

M'kati mwa chipangizo cha microfluidic chili ndi maphwando apakati ndi ma T omwe ma cell ndi nanoparticles amayenda.Kukonzekera kwamagulu kumapanga ma vortex ofunikira omwe amatsogolera kulowa kwa ma cell membranes ndi nanoparticles mwachibadwa amalowa mpata ukapezeka.

Nayi kuyerekezera kwa spiral vortex komwe kumapangitsa kuti ma cell asinthe pa mphambano ndi T-junction:

Ukadaulo wazachipatala umasintha dziko!Lowani nafe ndikuwona kupita patsogolo munthawi yeniyeni.Ku Medgadget, timapereka lipoti zaukadaulo waposachedwa, atsogoleri oyankhulana nawo, ndikutumiza mafayilo kuchokera kuzochitika zachipatala padziko lonse lapansi kuyambira 2004.

Ukadaulo wazachipatala umasintha dziko!Lowani nafe ndikuwona kupita patsogolo munthawi yeniyeni.Ku Medgadget, timapereka lipoti zaukadaulo waposachedwa, atsogoleri oyankhulana nawo, ndikutumiza mafayilo kuchokera kuzochitika zachipatala padziko lonse lapansi kuyambira 2004.