Lintlha tse ncha tse tsoang thutong e tsoelang pele ea Mokhahlelo oa 3 li boetse li hlalosa katleho ea VUMERITY® (Dilosimil fumarate) le mamello e ntlafalitsoeng ea mala.
Ha ho bapisoa le Ocrevus® (ocrelizumab), liphuputso tsa sebele li ile tsa lekola boleng ba melemo ea bophelo bo amanang le TYSABRI® (natalizumab)
Litšibollo tse ling tsa sebele li tlaleha melemo e metle ea PLEGRIDY® (peginterferon beta-1a) le AVONEX® (interferon beta-1a) ho bakuli ba tsofetseng ba nang le multiple sclerosis.
Cambridge, Massachusetts, September 11, 2020 (Global News)-Biogen Inc. (NASDAQ: BIIB) kajeno e phatlalalitse lintlha tse ncha tse totobatsang indasteri ea eona e pharaletseng e lebisang ho multiple sclerosis (MS ) Ho sebetsa hantle le polokeho ea motsoako oa phekolo.Lintlha tsena li tla hlahisoa nakong ea kopano ea borobeli ea kopanelo ea MSVirtual2020, American Multiple Sclerosis Treatment and Research Committee le European Multiple Sclerosis Treatment and Research Committee (ACTRIMS-ECTRIMS), e tla tšoaroa ho tloha ka la 11 Loetse 13, 2020.
"Mohlanka ea ka Sehloohong oa Bongaka oa Biogen Maha Radhakrishnan, MD, o itse: "Biogen e motlotlo hobane re ikemiselitse ho rarolla mathata a potlakileng le a nako e telele ao bakuli ba MS ba tobaneng le 'ona."Lintlha tseo re fanang ka tsona ho ACTRIMS-ECTRIMS li totobatsa liphetho tse ntlafalitsoeng.Potefolio ea rona e pharalletseng ea sehlahisoa sa MS e ntse e tsoela pele ho sebeletsa bakuli ba nang le MS e khutlelang morao, ho sa tsotelehe hore na ba hokae ts'ebetsong ea kalafo, 'me lipatlisiso tsa rona tse tsoelang pele le nts'etsopele Tsetela ho nts'etsopele ea batho ba nang le bokhoni ba ho sebelisa lithethefatsi.”
Lintlha tse ncha tsa Phase 3 li boetse li bontša katleho ea VUMERITY® (Dilosimide fumarate) le mamello ea GI e tlalehiloeng ke mokuli.Lintlha tse ncha tse tsoang lenaneong la bongaka la VUMERITY Phase 3 li tsoela pele ho hlalosa phekolo ea morao-rao ea fumarate ea Biogen Katleho le polokeho.Ha ho bapisoa le TECFIDERA® (dimethyl fumarate) (n = 251) le tšehetso, liphetho tsa thuto ea libeke tse hlano tsa EVOLVE-MS-2 li matlafalitse mamello ea gastrointestinal (GI) ea bakuli ba hlahlobiloeng ba amanang le phekolo ea VUMERITY Bohlokoa ba kliniki ba ho amohela (n = 253) e ntlafatsa phello ea eona ho boleng ba bophelo ba bakuli ba nang le MS khafetsa.Barupeluoa thutong e nkang VUMERITY ba boletse hore ha ba na monyetla oa ho ba le matšoao a ka mpeng a sitisang mesebetsi ea letsatsi le letsatsi kapa a amanang le khaello ea mosebetsi, mme ho na le lithethefatsi tse fokolang tse sebelisoang ho phekola matšoao a mala.
Tlhahlobo ea lipatlisiso ea phuputso e tsoelang pele ea EVOLVE-MS-1 e hlahlobile phello ea VUMERITY liphetohong tsa molumo oa boko le matšoao a mang a kliniki ho batho ba nang le MS (n = 365) ba phekolehileng ho fihlela lilemo tse peli.Liphuputso tse fapaneng li bontšitse hore ho fokotseha ha molumo oa boko ho ka amahanngoa le ho senyeha ha kelello, bokooa ba 'mele le ho fokotseha ha boleng ba bophelo ho bakuli ba MS.1,2, data ea EVOLVE-MS-1 e bontša:
Sekhahla sa selemo le selemo sa phetoho ea boko ba barupeluoa ba fumaneng kalafo ea VUMERITY ka lilemo tse peli se ne se tšoana le sa batho ba phetseng hantle.ka
Hoo e ka bang 90% ea bakuli ba fumanang phekolo ea VUMERITY ha ba na tsoelo-pele ea bokooa e tiisitsoeng, 'me hoo e ka bang 84% ha e na ho pheta-pheta nakong ea lilemo tse peli.
Lintlha tsa ho qetela tse tsoang thutong ea Phase 3 ea ENDORSE li tla boela li hlahisoe sebokeng, e leng se bontšang ka ho eketsehileng katleho e tsoelang pele le polokeho e hlalositsoeng hantle ea TECFIDERA ho bakuli ho fihlela lilemo tse 13.
Lintlha tsa 'nete tse tsoang tlhahlobisong e fapaneng ea batho ba hlahang khafetsa ba MS li bontša hore ka MS PATHS (Partner Advance Technology and Health Solutions), TYSABRI® (natalizumab), PLEGRIDY® (pegylated interferon beta-1a) Le AVONEX® (interferon beta-1a) e ntlafetse., Biogen e sebelisana 'moho le litsi tse etellang pele tsa MS Europe le United States ho hlahisa lintlha tse tloaelehileng, tsa boleng bo holimo ho tsoa ho batho ba fapaneng ba lefats'e la 'nete ba bakuli ba MS.Ho fihlela joale, bakuli ba fetang 17,000 ba kentse letsoho ho MS PATHS.Lintlha tse fumanoeng kalafong ea tikoloho ea 'nete li tšehetsa liphetho tse ntlafalitsoeng tse amanang le TYSABRI, PLEGIDYY le AVONEX.Liphetho tsa tlhahlobo e arohaneng le data ea MS PATHS li bontša:
Papisong ea pele ea mokhoa oa MS PATHS o tloaelehileng oa ho nahana ka matla a khoheli (MRI), liphetoho nakong e atolositsoeng ea nako ea dosing (EID; n = 85) ea natalizumab li bapisoa le boko bo amohetsoeng ba MRI (ho bolela ho latela lilemo tse 0.8).Hang ka libeke tse 'nè (Q4W; n = 569).Tlhahlobo e tlalehile hore ha ho na phapang e khōlō ho lefu le lecha la T2, mefuta e fapaneng ea lefu la T2 le tekanyo ea boko ba boko.Phapano ea li-scanner tsa MRI le li-protocol tsa ho fumana tšebetsong ea bongaka li etsa hore papiso ea liphetho tsa boko ba MRI e be phephetso.Liphuputso tse ngata tsa lefats'e la 'nete li bonts'itse hore katleho ea natalizumab EID e ts'oana le tekanyetso e lumelletsoeng ea Q4W.3-7Biogen e ntse e tsoela pele ho lekola katleho, polokeho le mamello ea natalizumab EID ka teko e lebelletsoeng ea NOVA (NCT03689972), mme e sa tsoa kenya kopo ea tsamaiso ea subcutaneous ho bolaoli ba taolo.Haeba e amohetsoe, E tla fana ka likhetho tse ling bakeng sa tsamaiso ea TYSABRI.
Ho latela tlhahlobo ea Neuro-QoL (Boleng ba Bophelo ho Mafu a Ts'ebetso ea Methapo), kalafo ea TYSABRI e na le ntlafatso e kholo ho boleng bo itseng ba bophelo ho feta Ocrevus® (ocrelizumab).Tlhahlobong ea sehlopha sa bakuli ba tšoanang ba tšoaroang ka TYSABRI kapa Ocrevus, ho ile ha hlokomeloa hore libaka tse 9 ho tse 12 tsa Neuro-QoL ho bakuli ba tšoaroang ka TYSABRI li ntlafalitsoe haholo (n = 144).Libaka tse 4 ho tse 12 li ntlafetse haholo (n = 502)).Ka kakaretso, sekhahla sa ntlafatso sa selemo le selemo sa TYSABRI se phahame ho feta sa Ocrevus, 'me liphapang tse kholo li bonoa likarolong tse tharo: tšusumetso e ntle le bophelo bo botle, ho khotsofatsoa ke mesebetsi le mesebetsi ea sechaba, le mathata a ho robala.
Ha ho bapisoa le bakuli ba MS ba ka tlase ho lilemo tse 60 (n = 729), liphello tsa kliniki tsa bakuli ba MS ho feta lilemo tse 60 (n = 286) li bontšitse hore lihlopheng tsa lilemo ka bobeli, PLEGRIDY le AVONEX li ka fana ka melemo ea phekolo.Lintlha li bonts'a hore tlhahlobo ea lebelo la ho sebetsa (PST) le tlhahlobo ea kutlo e fapaneng (CST) ea lihlopha tse peli tsa lilemo li ntlafetse nakong e fetang selemo.Ho phaella moo, boholo ba barupeluoa lihlopheng tse peli tsa lilemo ha baa ka ba khutlela morao nakong ea lilemo tse peli.
Lintlha tse tsoang thutong ea Mokhahlelo oa 1 oa BIIB091 li tšehetsa phekolo e tsoelang pele ea MSBiogen, 'me boitsebiso bo tsoang thutong ea Phase 1 ea BIIB091 le bona bo fanoe.BIIB091 ke inhibitor e nyenyane ea molek'hule e khethiloeng, e fetohang (e seng ea covalent) ea mosebetsi oa molomo oa Moemeli oa Bruton's tyrosine kinase (BTK).Lintlha li ile tsa lekola polokeho, mamello, pharmacokinetics le pharmacodynamics ea litekanyetso tse ntseng li eketseha tsa molomo tse ntseng li eketseha ho batho ba baholo ba phetseng hantle.Thibelo e khethiloeng ea BTK e ka ba molemo ho phekola MS ka ho thibela ts'ebetso ea lisele tsa B le lisele tsa myeloid ntle le ho fokotseha ha lisele tsa 'mele.
Tlhahiso ea data ho ACTRIMS-ECTRIMS: Hlokomela: Litlhahiso tsohle tsa poso tsa MSVirtual2020 li tla fumaneha inthaneteng ka 8 AM Eastern Time ka Labohlano la 11 Loetse 2020.
Ha ho bapisoa le dimethyl fumarate ho EVOLVE-MS-2, mamello e ntlafetseng ea GI ea Diroximel fumarate e amana haholo le bohlokoa ba bophelo bo botle ba bophelo (Poster 0214)
Phello ea Diroximel fumarate ho liphetoho tsa molumo oa boko le tsoelo-pele ea bokooa ho batho ba baholo ba nang le EVOLVE-MS-1 relapsing-remitting multiple sclerosis (Poster P0205)
Tšireletseho le katleho ea bakuli ba tšoaroang ka dimethyl fumarate le ho lateloa ka lilemo tse 13: liphetho tsa ho qetela tsa ENDORSE (sethala sa FC02.05-Sontaha, September 13th 1:48-2:00 US Eastern Time)
Liphetho tsa radiology tsa bakuli ba nang le litekanyetso tse atolositsoeng tsa nako ea Natalizumab ha li fapane le litekanyetso tse tloaelehileng tsa nako ho MS PATHS (Poster P0360)
Phello ea Natalizumab Boleng ba Bophelo ho Sehlopha sa Sebele sa Bakuli ba Multiple Sclerosis: Liphetho tsa Tsela ea MS (Poster P1036)
Litšobotsi le liphetho tsa kliniki tsa bakuli ba tsofetseng ba MS ba nang le Peginterferon Beta-1a kapa intramuscular interferon Beta-1a kalafo ea MS pathway (Poster P0843)
Thuto ea Mokhahlelo oa 1 oa BIIB091 (a Bruton's tyrosine kinase (BTK) inhibitor) ho barupeluoa ba baholo ba phetseng hantle: liphetho tsa pele (poster P0186)
Mabapi le VUMERITY® (Dilosemate Fumarate) VUMERITY ke fumarate ea molomo e nang le sebopeho sa lik'hemik'hale se fapaneng ka ho feletseng le TECFIDERA® (Dimethyl Fumarate), e amohetsoeng United States bakeng sa phekolo ea multiple sclerosis ho batho ba baholo Mefuta e phetoang khafetsa ea lefu lena e kenyelletsa li-syndromes tse arohaneng le lingaka, mafu a iphetang khafetsa le mafu a tsoelang pele a mafolofolo a bobeli.Ka mor'a ho kena 'meleng, VUMERITY e fetoloa ka potlako ho monomethyl fumarate, metabolite e tšoanang e sebetsang ea dimethyl fumarate.
VUMERITY e hanetsoe ho bakuli ba alejiki ho Diroximel fumarate, dimethyl fumarate kapa leha e le efe ea li-excipients tsa VUMERITY;le bakuli ba noang dimethyl fumarate.Litla-morao tse tebileng tsa VUMERITY li ipapisitse le data ea dimethyl fumarate (metabolite e ts'oanang e sebetsang joalo ka VUMERITY), ho kenyelletsa le ho kula le angioedema, leukoencephalopathy e tsoelang pele ea multifocal, e leng boko bo nang le monyetla o sa tloaelehang Ts'oaetso ea vaerase e amana le lefu kapa bokuli bo matla.Bokooa, ho fokotseha ka karolelano palo ea lymphocyte selemong sa pele sa kalafo, li-shingles le mafu a mang a tebileng, ho senyeha ha sebete le ho phalla.Liketsahalo tse mpe tse atileng haholo tse fumanoeng ho sebelisoa data ho tsoa ho dimethyl fumarate (e nang le metabolite e sebetsang e ts'oanang le VUMERITY) e ne e le ho hlatsa, bohloko ba ka mpeng, letšollo le ho nyekeloa ke pelo.
Ka kopo, tobetsa mona bakeng sa lintlha tsa bohlokoa tsa polokeho le lintlha tse felletseng tsa lengolo la ngaka, ho kenyeletsoa le lintlha tsa mokuli bakeng sa VUMERITY United States.
Mabapi le TECFIDERA® (dimethyl fumarate) TECFIDERA ke mokhoa oa phekolo oa ho khutlela ho multiple sclerosis (MS) ho batho ba baholo.Ke moriana o laetsoeng ka ho fetesisa oa ho khutlela mokhoeng oa MS lefatšeng.Ho ipakile ho fokotsa sekhahla sa ho ipheta ha MS le ho e liehisa.E hatela pele ho ea ho bokooa 'me e ama palo ea maqeba a boko ba MS,' me e paka hore ts'ireletso ea tšobotsi ea bakuli ba nang le MS e khutletseng morao e ntle.TECFIDERA e amohetsoe linaheng/litikolohong tse 69 'me e se e alafiloe bakuli ba 475,000, ho bolelang hore bakuli ba lilemo tse fetang 950,000 ba sebelisa le ho fana ka litaelo tsa TECFIDERA.Ho bona, bakuli ba 6,335 (lilemo tsa bakuli ba 14,241) ba tsoa litekong tsa bongaka8.
TECFIDERA e hanetsoe ho bakuli ba alejiki ho dimethyl fumarate kapa lisebelisoa life kapa life tsa TECFIDERA.Litla-morao tse matla li kenyelletsa ho kula le angioedema, 'me linyeoe tsa tsoelo-pele ea multifocal leukoencephalopathy (mafu a sa tloaelehang a kotsi a bakoang ke lefu kapa bokooa bo tebileng) a hlokometsoe ho bakuli ba TECFIDERA ba nang le lymphopenia ea nako e telele, le hoja karolo ea lymphopenia e sa tsitsa maemong ana. .Litla-morao tse ling tse mpe li kenyelletsa ho fokotseha ha kakaretso ea palo ea lymphocyte selemong sa pele sa kalafo, li-shingles le mafu a mang a tebileng, tšenyo ea sebete le ho phatloha.Litekong tsa bongaka, liketsahalo tse mpe tse atileng haholo tse amanang le TECFIDERA e ne e le ho phatloha, bohloko ba ka mpeng, letšollo le ho nyekeloa ke pelo.
Ka kopo, tobetsa mona bakeng sa lintlha tsa bohlokoa tsa polokeho le lintlha tse felletseng tsa lengolo la ngaka, ho kenyeletsoa le lintlha tsa mokuli tsa TECFIDERA United States, kapa etela sebaka sa Marang-rang sa sehlahisoa naheng ea heno.
Mabapi le TYSABRI® (natalizumab) TYSABRI ke phekolo e sebetsang bakeng sa relapsing multiple sclerosis (RMS), e ka sebelisoang bakeng sa ho khutlela ho MS ho batho ba baholo.Liteko tsa meriana li pakile hore phekolo ena e ka liehisa tsoelo-pele ea bokooa ba 'mele le ho fokotsa Ho thehoa ha maqeba a macha a boko le ho fokotsa ho ipheta.TYSABRI e amohetsoe linaheng/litikolohong tse 80.Ho latela liteko tsa tleliniki le tlhaiso-leseling ea ngaka, TYSABRI e fumane kalafo ea TYSABRI bakeng sa batho ba fetang 213,000 lefatšeng ka bophara, ka boiphihlelo ba lilemo tse fetang 835,000 tsa bakuli.9
TYSABRI e eketsa kotsi ea ho ba le leukoencephalopathy (PML), e leng tšoaetso e sa tloaelehang ea boko e amanang le lefu kapa kholofalo e matla.Ntho e kotsi e eketsang kotsi ea PML ke boteng ba li-anti-JC virus antibodies, tšebeliso ea li-immunosuppressive agents le TYSABRI bakeng sa phekolo e telele.Bakuli ba nang le mabaka ana a mararo a kotsi ba na le kotsi e kholo ea PML.Ha lingaka li qala le ho tsoela pele ka kalafo ka TYSABRI, li lokela ho nahana hore na melemo e lebelletsoeng ea TYSABRI e lekane ho fokotsa kotsi ena.
TYSABRI e boetse e eketsa kotsi ea ho tšoaroa ke encephalitis le meningitis e bakoang ke kokoana-hloko ea herpes simplex le varicella-zoster.Ho latela litlaleho, bakuli ba MS ba fumanang TYSABRI ba na le linyeoe tse matla, tse behang bophelo kotsing esita le tse bolaeang kamora 'maraka.Sebakeng sa ka mor'a ho bapatsa, ho boetse ho na le ts'enyo e kholo ea sebete, ho kenyelletsa le ho hloleha ho matla ha sebete ho hlokang ho fetisoa.Liketsahalo tse ling tse mpe tse mpe tse etsahetseng ho bakuli ba tšoaroang ka TYSABRI li kenyelletsa karabelo ea hypersensitivity (joalo ka karabelo e fapaneng) le ts'oaetso, ho kenyelletsa le ts'oaetso e nkang monyetla le mafu a mang a atypical.
Ka kopo, tobetsa mona bakeng sa lintlha tsa bohlokoa tsa polokeho, ho kenyeletsoa litemoso tse ka lebokoseng, le lintlha tse felletseng tsa lengolo la ngaka, ho kenyeletsoa le tataiso ea meriana ea US TYSABRI, kapa etela sebaka sa Marang-rang sa sehlahisoa naheng ea heno.
Mabapi le PLEGRIDY® (pegylated interferon β-1a) PLEGRIDY ke subcutaneous pegylated interferon, hang ka mor'a libeke tse ling le tse ling tse peli, bakeng sa mofuta o tloaelehileng oa multiple sclerosis (MS) ho batho ba baholo, e leng mofuta o tloaelehileng oa MS.Sebopeho se tloaelehileng.PLEGRIDY e amohetsoe hajoale linaheng/litikolohong tse fetang 60, ho kenyeletsoa United States, Canada, Australia le Switzerland, le European Union kaofela.Ho latela lintlha tsa ngaka, hoo e ka bang batho ba 57,000 lefatšeng ka bophara ba fumane phekolo ea PLEGRIDY, ka phihlelo ea lilemo tse fetang 107,000 tsa mokuli.10Biogen e ntse e tsoela pele ho sebetsa ho fana ka PLEGRIDY linaheng / libaka tse ling ho pota lefatše.
Katleho le polokeho ea PLEGRIDY li tšehetsoa ke e 'ngoe ea liphuputso tse kholo ka ho fetisisa tsa bohlokoa, tse sebelisitseng phekolo ea interferon ho bakuli ba nang le MS e khutlelang morao.Liphuputsong tsa bongaka, ho 'nile ha pakoa hore PLEGRIDY e ka fokotsa haholo sekhahla sa ho khutla ha MS, ea fokotsa tsoelo-pele ea bokooa le ho fokotsa palo ea likotsi tsa boko ho MS.Ka nako e ts'oanang, ho ipakile hore polokeho ea bakuli ba nang le MS e khutletseng hape e ntle.Litla-morao tse tlalehiloeng li kenyelletsa mathata a sebete, ho kenyeletsa ho hlōleha ha sebete le ho eketseha ha li-enzyme tsa sebete;ho tepella maikutlong kapa mehopolo ea ho ipolaea;karabelo e matla ea allergic;mathata a pelo, ho akarelletsa le congestive heart failure;mafu a autoimmune;ho fokotseha ha palo ea lisele tse tšoeu tsa mali kapa platelet;le mats'oao.Litekong tsa bongaka, liketsahalo tse mpe tse atileng haholo tse amanang le PLEGRIDY e ne e le karabelo ea sebaka sa ente le matšoao a kang a ntaramane.Lenane la diketsahalo tse mpe le ka fumanoa ho leibole e felletseng ea sehlahisoa sa PLEGRIDY bakeng sa naha ka 'ngoe e amoheloang.
Ka kopo, tobetsa mona bakeng sa lintlha tsa bohlokoa tsa polokeho le lintlha tse felletseng tsa litaelo, ho kenyeletsoa le litataiso tsa kalafo ea lithethefatsi tsa US PLEGRIDY, kapa etela sebaka sa Marang-rang sa sehlahisoa naheng ea heno.
Mabapi le AVONEX® (Interferon beta-1a) AVONEX e etselitsoe ho khutlisa MS, 'me e amohetsoe linaheng tse fetang 90.Ho ea ka boitsebiso ba ngaka, batho ba fetang 580,000 lefatšeng ka bophara ba fumane phekolo ea AVONEX, ba nang le phihlelo ea lilemo tse fetang limilione tse 2.6.11AVONEX e khethiloe bakeng sa phekolo ea relapsing multiple sclerosis (MS), ho kenyelletsa le li-syndromes tse arohaneng le lingaka, batho ba baholo ba khutlelang morao ba nang le lefu le bonolo le lefu la bobeli le tsoelang pele.
Ho ea ka litlaleho, bakuli ba fumanang AVONEX ba na le matšoao a ho tepella maikutlong, maikutlo a ho ipolaea kapa psychosis, 'me hangata linyeoe tsa ho ipolaea li eketsehile.Ke bakuli ba fokolang ba tlalehang tšenyo e khōlō ea sebete, ho akarelletsa le ho hlōleha ha sebete.Ho 'nile ha tlalehoa liketsahalo tse sa tloaelehang tsa ho kula.Le hoja beta interferon e se na chefo e tobileng ea pelo, ho tlalehoa hore ha ho bakuli ba nang le ts'oaetso e tsejoang ba nang le bothata ba ho hloleha ha pelo, lefu la pelo, le lefu la pelo la congestive heart failure.Boiphihlelo ba ka mor'a ho bapatsa bo bontša hore palo ea lisele tsa mali tsa peripheral e fokotsehile.Ho latela litlaleho, bakuli ba sebelisang AVONEX ba na le ts'oaetso, ho kenyelletsa le ba se nang nalane ea ho ts'oaroa.Ho tlalehiloe mafu a autoimmune a litho tse ngata tse lebisitsoeng.Ho khothalletsoa ho etsa lik'hemik'hale tse tloaelehileng tsa mali, hematology, sebete le liteko tsa ts'ebetso ea qoqotho kamehla.
Ka kopo, tlanya mona bakeng sa lintlha tsa bohlokoa tsa polokeho le lintlha tse felletseng tsa litaelo, ho kenyeletsoa le litataiso tsa kalafo ea lithethefatsi bakeng sa AVONEX ea United States, kapa etela sebaka sa marang-rang sa sehlahisoa naheng ea heno.
Mabapi le Biogen At Biogen, sepheo sa rona se hlakile: re bo-pula-maliboho lefapheng la neuroscience.Biogen e sibolla, e nts'etsapele le ho fana ka liphekolo tse ncha lefatšeng ka bophara bakeng sa batho ba nang le mafu a matla a methapo ea kutlo le mafu a neurodegenerative le liphekolo tse amanang le ona.Biogen ke e 'ngoe ea likhamphani tsa pele tsa lefats'e tsa biotechnology, tse thehiloeng ka 1978 ke Charles Weissmann, Heinz Schaller, Kenneth Murray, le bahapi ba Khau ea Nobel Walter Gilbert le Phillip Sharp.Kajeno, Biogen e na le setsi se ka sehloohong sa lithethefatsi bakeng sa phekolo ea multiple sclerosis, e hlahisitse phekolo ea pele e amohelehang ea ho fokotsa mesifa ea mokokotlo, biosimilars ea khoebo ea biologics e tsoetseng pele, 'me e tsepamisitse maikutlo ho nts'etsopele ea multiple sclerosis le neuroimmunology.Lefu la Alzheimer's le 'dementia', mafu a neuromuscular, mathata a ho sisinyeha, ophthalmology, immunology, mafu a neurocognitive, lefu la pelo le bohloko.
Re tla lula re phatlalatsa tlhahisoleseling e ka bang bohlokoa ho batseteli webosaeteng ea rona www.biogen.com.Ho ithuta haholoanyane, ka kopo etela www.biogen.com 'me u re latele mecheng ea litaba tsa sechaba Twitter, LinkedIn, Facebook, YouTube.
Biogen Safe Harbor Phatlalatso ena ea boralitaba e na le liphatlalatso tse lebeletsoeng pele, ho kenyeletsoa le lipolelo tse mabapi le melemo e ka bang teng, polokeho le katleho ea VUMERITY, TECFIDERA, TYSABRI, PLEGIIDY le BIIB091 tlas'a lipehelo tse sireletsehileng tsa boema-kepe tsa Molao oa Phetoho ea Linyeoe tsa Securities tsa 1995;Liphetho tsa lintlha tse ling tsa 'nete;boithuto ba EVOLVE-MS-2, boithuto ba ENDORSE Phase 3 le liphetho tsa boithuto tsa BIIB091 Mokhahlelo oa 1;Boitsebiso le kalafo ea MS;moralo oa rona oa nts'etsopele ea kalafo ea MS;puisano e ka bang teng ea taolo, tlhahiso le tumello le Litokisetso tsa nako;bokhoni ba khoebo ea Biogen, ho kenyeletsoa VUMERITY, TECFIDERA, TYSABRI, PLEGRIDY le BIIB091;le likotsi le ho hloka bonnete tse amanang le nts'etsopele ea lithethefatsi le khoebo.Lipolelo tsena tse shebileng pele li ka sebelisa mantsoe a kang “tebello”, “lebella”, “lumeloa”, “ka khona”, “kakanya”, “lebela”, “lebelli”, “tebello”, “ikemisetse”, “mohlomong” Ho tsebahatsa.“,” “ rera”, “mohlomong”, “kgoneho”, “thato”, “thato” le mantswe a mang le mareo a nang le meelelo e tshwanang.Nts'etsopele ea lithethefatsi le khoebo li kenyelletsa kotsi e kholo, 'me ke palo e nyane feela ea merero ea lipatlisiso le nts'etsopele e lebisang khoebong ea lihlahisoa Liphetho tsa liteko tsa pele tsa kliniki li kanna tsa se ke tsa emela liphetho tse felletseng kapa liphetho tsa liteko tsa morao-rao kapa tse kholo tsa kliniki, leha e le hore li ka se be teng. ba netefatsa tumello ea taolo.Ha oa lokela ho itšetleha haholo ka lipolelo tsena kapa boitsebiso ba saense bo fanoeng.
Lipolelo tsena li kenyelletsa likotsi le ho se kholisehe, 'me li ka etsa hore liphetho tsa sebele li fapane haholo le liphetho tse bontšitsoeng lipolelong tse joalo, ho kenyelletsa empa ho sa felle feela ho etsahala ha liketsahalo tse mpe tsa ts'ireletso le/kapa matšoenyeho a sa lebelloang a ka bakoang ke lintlha tse ling kapa tlhahlobo;litjeho tse sa lebelloang kapa tieho Likotsi;Matšoenyeho a sa lebelloang a ka hlaha ka lebaka la lintlha tse ling, tlhahlobo kapa liphetho nakong ea liteko tsa bongaka;Ha re khone ho sireletsa le ho tiisa ts'ebetsong lintlha tsa rona, litokelo tsa thepa ea bohlale le beng ba bang, le lipelaelo tse amanang le likopo tsa thepa ea mahlale le liphephetso ;Mekhatlo e laolang e ka 'na ea hloka boitsebiso bo eketsehileng kapa lipatlisiso tse eketsehileng, kapa e ka 'na ea se ke ea khona ho fana ka tumello kapa ea liehisa tumello ea batho ba rona ba sebelisang lithethefatsi kapa katoloso ea ho ngola lihlahisoa;ho hloleha ho fumana tumello ea taolo libakeng tse ling;likopo tsa melato ea lihlahisoa;likotsi tsa tšebelisano-'moho ea batho ba boraro;le Seoa se ntseng se tsoela pele sa COVID-19 se na le litlamorao tse tobileng le tse sa tobang khoebong ea rona, liphetho tsa ts'ebetso le maemo a lichelete.Lintlha tse ngata empa eseng kaofela tse thathamisitsoeng ka holimo li ka etsa hore liphetho tsa sebele li fapane le litebello tsa rona ho lipolelo leha e le life tse lebeletsoeng pele.Batseteli ba lokela ho nahana ka polelo ena ea temoso le mabaka a kotsi ao re a hlokometseng tlalehong ea rona ea morao-rao ea selemo kapa kotara le litlaleho tse ling tseo re li kenyang ho Securities and Exchange Commission.Lipolelo tsena li ipapisitse le litumelo le litebello tsa rona tsa hajoale mme li emela feela boemo ho tloha ka letsatsi la phatlalatso ena ea litaba.Ebang ke ka lebaka la tlhahisoleseling e ncha, liketsahalo tsa nako e tlang kapa mabaka a mang, ha re itlame ka ho ntlafatsa phatlalatsa liphatlalatso leha e le life tsa bokamoso.
Mowry EM, Beheshtian A, Waubant E, joalo-joalo Boleng ba bophelo ho multiple sclerosis bo amana le moroalo oa mafu le matšoao a tekanyo ea molumo oa boko.Neurology.2009;72(20):1760-1765.
Lanz M, Hahn HK, Hildebrandt H. Boko ba boko le ho senyeha ha kelello ho multiple sclerosis: tlhahlobo [Litokiso tse hatisitsoeng li hatisoa ho J Neurol.2008 Hlakola;255(2):309-10].Journal of Neurology.2007;254 Tlatsetso 2: II43-II48.
Foley J, Xiong K, Hoyt T, joalo-joalo Boemo bo bobebe ba serum neurofilament ho bakuli ba nang le relapsing-remitting multiple sclerosis bo ile ba fetoloa ho tloha ho natalizumab hang ka libeke tse ling le tse ling tsa 4 ho ea ho tsamaiso ea nako e telele.AAN 2020;S10.009.
Butzkueven, Kappos L, Spelman T, joalo-joalo Bakuli ba ileng ba fetohela ho natalizumab bakeng sa dosing ea nako e telele kapa ho boloka tekanyo ea nako e tloaelehileng ea nako ba ne ba se na phapang e khōlō liphellong tsa ho ipheta: ho bapisoa ha katleho ea palo ea bakuli ba lenaneong la ho shebella TYSABRI.ECTRIMS 2019;P1033.
Yamout B, Sahraian MA, Ayoubi NE, joalo-joalo Ho sebetsa hantle le polokeho ea natalizumab e tsamaisoang ka nako e telele.Bothata ba Mult Scler Relat.2018;24:113-116 .
Zhovtis Ryerson L, Frohman TC, Foley J, joalo-joalo Tsamaiso e atolositsoeng ea nako ea natalizumab ho multiple sclerosis.J Neurol Neurosurgery Psychiatry.2016;87:885-889.
Bomprezzi R, PawateS.Tekanyo e atolositsoeng ea nako ea natalizumab: lilemo tse 7 tsa boiphihlelo litsing tse peli.Ther Adv Neurol Disord.2014;7: 227-231 .
Ho tloha ka la 30 Phuptjane 2020, ho ipapisitsoe le lintlha tse kopaneng tsa kamora thekiso ho tsoa litekong tsa bongaka tsa lengolo la ngaka le ho pepesetsoa TECFIDERA.
Ho tloha ka la 31 Phupu 2020, data e kopantsoeng ka mor'a thekiso e ipapisitse le lengolo la ngaka le liteko tsa bongaka tsa ho pepeseha ha TYSABRI.
(Bloomberg) - SAP SE ea theko ea theko e theohile hoo e ka bang 21%, e leng ho theoha ho hoholo ha letsatsi le le leng ho tloha ka 1999. Nakong e fetileng, k'hamphani e thehiloeng Walldorf e ile ea theola ponelopele ea eona ea chelete ea selemo se tletseng 'me ea re e lebeletse chelete e ncha ea chelete.E notletsoe halofo ea pele ea 2021, tlhoko e se e nyenyefalitsoe.Tekong ea Christian Klein, e ile ea e-ba CEO ea khethehileng ka April.Seoa sena se tla liehisa lekeno la maru la SAP, thekiso ka kakaretso le lipheo tsa phaello ea ts'ebetso bakeng sa selemo kapa tse peli, haholo joalo ka ha k'hamphani ea software e boletse polelong ea Sontaha.SAP e boletse hore e lebeletse kholo e fokolang le phaello ea phaello lilemong tse peli tse tlang, 'me e tla tsamaisa moralo oa eona oa leano la 2023 ho 2025. Klein o itse ka pitso ea kopano ka Mantaha hore o lebeletse hore SAP e tla bua polelong ea hore pono e fetileng "e nka hore hore moruo o tla buloa hape 'me ho koalloa ha baahi ho fokotsehe, ho lebisang ntlafatsong ea butle-butle tikolohong ea tlhokahalo karolong ea boraro le ea bone. "Khampani e sa tsoa bolela esale pele hore ka 2020, ho itšetlehile ka litekanyetso tse tsitsitseng tsa phapanyetsano, lichelete tse fetotsoeng li tla fihla ho li-euro tse limilione tse likete tse 27,2 ho ea ho li-euro tse limilione tse likete tse 27,8 (32,2 limilione tse likete tse limilione tse likete tse 32,9), tse ka tlaase ho feta kamoo ho neng ho lebeletsoe kateng 'me li eketsehile ho li-euro tse limilione tse likete tse 28,5 ho tloha tataisong e fetileng. ea li-euro tse limilione tse likete tse 27.8.Euro.SAP e boetse e boletse hore khoebo ea eona ea Concur ha e sa tla rua molemo ho chelete e amanang le maeto selemong sena.Mohlahlobi oa OddoBHF Nicholas David o ngotse tlalehong hore ho thata ho fumana liphello tse ntle ho tsoa ho liphetho News.Litebello tsa 'maraka bakeng sa litabatabelo tsa nako ea bohareng li / li tšohile, empa litabatabelo tse ncha li tlase ho feta litebello tse se nang tšepo. ”Qualtrics IPOSAP e boletse hore karolo ea eona ea software ea Qualtrics e boemong bo tsoetseng pele ba lethathamo.E phatlalalitse ka Phupu hore e nkile qeto ea ho fumana k'hamphani ka theko ea rekoto mme e phatlalatse US ka nako e ka tlase ho lilemo tse peli.Ena e bile phetoho e neng e sa lebelloa mme e bonts'itse phetoho ea leano tlasa boetapele ba Klein."Re tsoetse pele haholo ho itokisetsa Qualtrics 'IPO," Ofisiri e ka Sehloohong ea Lichelete Luka Mucic o boletse ka mohala ka Mantaha."Ts'ebetso e matla ea kotara ea Qualtrics e tla rala motheo oa kholo e eketsehileng selemong se tlang."Pono e ncha e fetotsoeng lekeno la maru e lebelletsoe ho nyoloha ho tloha ho li-euro tse limilione tse likete tse 8 ho isa ho li-euro tse libilione tse 8.2 ka 2020, e tlase ho feta khakanyo e fetileng ea li-euro tse limilione tse likete tse 8.3 ho isa ho li-euro tse limilione tse likete tse 8.7.Phaello ea ts'ebetso ea Euro ea selemo sena e tla ba lipakeng tsa 8.1 limilione tse likete le li-Euro tse limilione tse likete tse 8,5, e leng tlase ho feta li-Euro tse limilione tse likete tse 8,7 tse lebelletsoeng.SAP e ekelitse sepheo sa eona sa bohareng ba nako ea ho feta li-Euro tse limilione tse likete tse 36 ka chelete eohle ea chelete ka 2025 'me e tla fihla ho li-Euro tse limilione tse likete tse 35 ka 2023.Phaello ea kotara ea boraro ea ts'ebetso eo e seng ea IFRS kotareng ea boraro e theohile ka 12% selemo le selemo ho ea ho li-euro tse limilione tse likete tse 2.07.Ha ho bapisoa le li-euro tse limilione tse likete tse 2.15 tse lebelletsoeng ke bahlahlobisisi ba hlahlobiloeng ke Bloomberg, lekeno nakong eo le theohile ka 4% ho isa ho li-euro tse limilione tse likete tse 6.54, athe ponelopele ea mohlahlobi e ne e le li-euro tse limilione tse likete tse 6.89., CEO ea SAP ka PandemicU.K.CMA e iketsetsa tsela ea eona 'me e qala lipatlisiso tsa antitrust khahlanong le Sinch, SAP Division DealSAP e fetisetsoa ho JP Morgan Stanley,' me JP Morgan o etsa Qualtrics IPO (lintlafatso tsa stock, maemo a mang).Ka kopo etela Bloomberg.com ho re etela le ho ingolisa hona joale.Boloka boemo bo ka sehloohong e le mohloli o tšepahalang ka ho fetisisa oa litaba tsa khoebo.©2020 Bloomberg LP
Ralitaba oa San Francisco o buile ka bohlokoa ba tsamaiso ea Biden ho li-portfolio tsa matsete moqoqong o mong le o mong le bareki.
Basebelisi ba sa kang ba beha taelo sethaleng sefe kapa sefe sa JD ba ka fumana li-coupons tsa theolelo!Ka karete ea hau ea Visa, tobetsa ho lefa ho JD.com lekhetlo la pele 'me u natefeloe ke litheolelo!
Mohapi oa Khau ea Nobel litabeng tsa moruo, moprofesa oa Univesithi ea Yale Robert Shiller o khothalelitse bo-ramatsete hore ba be hlokolosi ka 'maraka oa setoko oa blockbuster kholomong ea morao-rao ea New York Times.
Khamphani e boletse Lee Kun-hee, ea hahileng Samsung Electronics hore e be senatla sa lefats'e sa li-smartphones, li-semiconductors le li-TV, o hlokahetse ka Sontaha kamora ho kena sepetlele ka lilemo tse fetang tse ts'eletseng ka lefu la pelo ka Sontaha.Lee o lilemo li 78 selemong sena.O ile a theha Sehlopha sa Samsung ho ba kopano e kholo ka ho fetisisa Korea Boroa mme ea e-ba monna ea ruileng ka ho fetisisa Korea Boroa.Jeong Sun-, CEO oa k’hamphani ea lipatlisiso ea Chaebul.com, o itse: “Ho phahama ho makatsang ha Lee Korea le kamoo Korea Boroa e kenellang ho ikopanya ha lichaba tsa lefatše ke tšoantšetso hoo lefu la hae le tla hopoloa ke Makorea a mangata.
Lilemo tse 'nè ka mor'a ho putlama ha BHS, na indasteri ea lichelete e 'nileng ea nyatsoa ka ho hlōleha ho fumana mathata a fetohile?
Ho ea ka litlaleho tsa CNBC, Jack Ma, mothehi oa Alibaba Group Holdings Limited (NYSE: BABA), o boletse ka Moqebelo hore linyehelo tse peli tsa pele tsa sechaba tsa Ant Group (IPOs) Shanghai le Hong Kong e tla ba k'hamphani e kholo ka ho fetisisa lefatšeng.Se etsahetseng: CNBC e boletse hore theko ea IPO e ne e le Labohlano bosiu, empa Jack Ma ha a ka a senola palo e tobileng, e tla phatlalatsoa bekeng e tlang.Histori ea batho-e khethiloe ka ntle ho New York City."Ma Yun o boletse Sebokeng sa Shanghai Bund.Ralimilione oa Lechaena o bitsitse taba ena “mohlolo.”O itse: “Ha rea ​​ka ra iteta sefuba ho nahana ka hona lilemong tse hlano kapa tse tharo tse fetileng."Ma Yun o boetse a kopa liphetoho tsa libanka le hore ho thehoe mokhoa o mocha oa libanka o kenyeletsang bohle.Hobaneng ho le bohlokoa: Linyehelo tsa pele tsa sechaba tsa lik'hamphani tse tšehelitsoeng ke Alibaba li ka hlahisa chelete e ka bang bilione e le 'ngoe, e tla etsa hore e be Saudi Aramco Phatlalatso e kholo ka ho fetesisa ea pele ea sechaba ea US $ 29.4 billion.Setoko sa Aramco se fanoeng ka December 2019 se ile sa hlola Alibaba mme sa hapa moqhaka oa IPO e kholo ka ho fetisisa.Ho latela litlaleho, letlole le ikemetseng la leruo la Singapore GIC Private Limited le ka thathamisoa lethathamong lena le mabeli.Matsete a feta US $ 1 bilione.Ho latela Reuters, Temasek oa Singapore, motseteli ea seng a ntse a le teng oa Ant, le eena o bontšitse thahasello ho setoko.Khato ea theko: Theko ea setoko sa Alibaba e koetse hoo e ka bang 1.2% ka Labohlano ho isa ho US $ 309.92.E nyolohile ka 0.11% nakong ea khoebo ea kamora lihora tse ngata.Litumellano tse ling tse tsoang ho Ben Singa * Tlanya mona ho sheba mekhoa ea khetho ea Ben Singa * Quibi ea putlama-khopolo ena ha e matla ka ho lekaneng, boetapele ba Benzinga.com (C) bo boletse ka 2020: "Kapa "Nako" ha e eo.Benzinga ha e fane ka keletso ea lichelete.litokelo tsohle li sirelelitsoe.
Nehelana hang-hang ho tšehetsa mokhatlo oa baphaphathehi oa Machaba a Kopaneng, e le hore baphaphathehi ba ka fumana lisebelisoa tsa tšohanyetso ho sebetsana le nako ea lipula le ho ba pholosa tlokotsing!
Ho bonolo ho reka li-stock, empa ho thata ho reka lihlahisoa tse nepahetseng ntle le leano le lekiloeng ka nako.Joale, ke stock efe e ntle ka ho fetisisa eo u ka e rekang kapa ea e beha lethathamong la litebelo hona joale?
Bokamoso bo ile ba theoha haholo.Mmaraka oa setoko o kanna oa tsamaea le baetapele ba joalo ka Microsoft le Tesla.Ha likhetho li ntse li atamela le linyeoe tsa coronavirus li ntse li eketseha, ena e ne e le beke e kenang e phahameng ka ho fetisisa.
Harry Markopolos (Harry Markopolos), setsebi sa pele sa li-derivatives se ileng sa fetohela ho mofuputsi ea ikemetseng oa bomenemene ba lichelete, o ile a fumana $ 65 limilione tse likete tsa Bernie Madoff Ponzi scheme, empa a hlokomolohuoa ke SEC Ka lilemo tse robong.Joaloka mohlahlobisisi ea hlakileng oa balaoli ba US, Harry joale o nka lefapha la tlhahlobo ea lichelete le indasteri ea inshorense e le nyeoe e latelang e kholo ea bomenemene ea lichelete e tla senoloa.
Selemo se secha sa Hang Seng sa marang-rang se huloang lekhetho se fana ka lilemo tse 10 tsa chelete e kenang e sa fetoheng 'me se tiisetsa 1.73% -2% ea chelete e kenang ka hare ho naha.Ho nka feela metsotso e 10 ho etsa kopo ea inshorense inthaneteng mme o nke khato hang-hang.
Batho ba bararo ba tsebang taba ena ba boletse hore motlatsi oa holimo oa iPhone, Foxconn oa Taiwan, o thehile sehlopha se sebetsang ho hanela tšusumetso e ntseng e hola ea moetsi oa lisebelisoa tsa elektroniki oa China Luxshare.Khamphani e lumela hore Luxshare ke eona e busang.tshoso e tebileng.E 'ngoe ea mehloli e boletse hore morero ona o thehiloe ke mothehi oa Foxconn Guo Taiming mme sepheo ke Luxshare <002475.SZ> ntlo-kholo ea Dongguan.Khampani ha e tsejoe hakaalo linaheng tse ling, empa e lebelletsoe ho ba k'hamphani ea pele ea ho bokana naheng ea China.Ntlo-kholo ea iPhone-ho fihlela joale, turf e ntse e busoa ke baetsi ba Taiwan.Mohloli o boletse hore sehlopha sa basebetsi se thehiloe selemong se fetileng mme se ntse se etsa lipatlisiso ka thekenoloji ea Luxshare, merero ea ho atolosa, leano la ho hira le hore na k'hamphani (hona joale e na le karolo ea 5 lekholong ea chelete ea Foxconn) e tšehetsoa ke mokhatlo ofe kapa ofe oa 'muso oa Chaena.
Moputso o ka sehloohong oa beke ena le tlaleho ea data ea moruo e tla lokolloa hamorao bekeng ena, 'me boholo ba lihlahisoa tsa FAANG li tlalehoa ka mor'a ho koaloa ka Labone.
Tlaleho ea meputso ea kotara ea boraro ea AMD (AMD) e reretsoe ho lokolloa kamora ho koaloa ka Labobeli, e leng nako e khahlisang indastering ea semiconductor.The Wall Street Journal e tlalehile hore AMD (AMD) e rera ho atolosa khoebo ea eona ka mafolofolo ka ho fumana thepa (XLNX) (XLNX).Ka nako e ts'oanang, tlholisano ea eona e kholo (INTC) e ntse e sebetsa ka thata ho tsoela pele ho hlahisa mahlale a tsoetseng pele a tlhahiso a hlokahalang ho etsa li-semiconductors tsa boleng bo holimo.
Reka mabenkeleng a marang-rang a feshene 'me u qete ka karete ea Visa ho natefeloa ke phokotso ea 20%!Fumana pokello ea morao-rao ea Luisa Via Roma le Taylor hona joale!
Setsebi sa CFRA, Garrett Nelson, o boletse puisanong le Yahoo Finance ka Labohlano hore haeba Joe Biden (Joe Biden) a ka hapa likhetho tsa mopresidente, Tesla (NASDAQ: TSLA) e tla ba mohlodi e moholo.Se etsahetseng: Nielsen o itse Tesla e tla ba "e 'ngoe ea likhamphani tse kholo ka ho fetisisa" hobane k'hamphani ke "koloi e hloekileng ea motlakase."Mohlahlobisisi o bontšitse hore mmuso oa Biden o tla fana ka lithuso tse kholo bakeng sa likoloi tsa motlakase.Bahlahlobisisi ba CFRA ba bontšitse hore Biden e khothalelitse "katoloso e kholo ea lekhetho la koloi ea motlakase" le "kaho e kholo ea liteishene tsa ho tjhaja likoloi tsa motlakase."Nielsen o itse: “Le nahana ho eketsa palo ea liteishene tse tjhajang likoloi tsa motlakase ka makhetlo a ka bang 20.E tla thusa haholo ho tsebahala ha likoloi tsa motlakase."Bohlokoa: Nakong ea ngangisano ea ho qetela ea mopresidente Tennessee bekeng e fetileng, Biden o itse mmuso oa hae o tla tsetela liteishene tsa ho tjhaja likoloi tsa motlakase tse 50,000 tseleng e kholo.Bakhethoa ba re liteishene tsena tsa ho tjhaja li tla lebisa United States ho ba le "bokamoso".Motlatsi oa mopresidente oa mehleng o lumela hore pono ea hae ea likoloi tsa motlakase e ka sebetsana le phetoho ea maemo a leholimo le ho theha "mesebetsi e mecha e lefang haholo."Khamphani e etelletsoeng pele ke Elon Musk e phatlalalitse kotara ea boraro bekeng e fetileng Lekhetho e ne e le US $ 8.77 billion, keketseho ea 39% selemo le selemo;Ketso ea theko: Likabelo tsa Tesla li koetsoe ka hoo e ka bang 1.2% ka Labohlano ho isa ho US $ 420.63.Haeba Joe Biden a hapa TSLA DateFirmActionHo tloha tsa morao-rao likhethong tsa Mphalane 2020 Likarolo Morgan Stanley o boloka boima bo lekanang (Mphalane 2020) Canaccord Genuity e boloka khoebo e tšoaretsoeng ka Mphalane 2020 mme e feta 'maraka o pharalletseng ntle le lehlakore.Sheba lintlha tse ling tsa mohlahlobi bakeng sa TSLA.Sheba lintlha tsa morao-rao tsa mohlahlobisisi* Tlhahlobo ea morao-rao ea Benza mabapi le khoebo * Rives Musk o boletse hore litšebeletso tsa khiriso tsa khoeli le khoeli li tla ba teng selemong se tlang.Jim Kramer o boletse hore Jim Tesla ke "stoko sa bohlanya" ka 2020 (C) Benzinga.com, e leng "phoso" Benzinga ha e fane ka keletso ea lichelete.Litokelo tsohle li sirelelitsoe.
Ke leano lefe la matsete le atlehileng ho feta nako?Matsete a kholo.Litsebi tsa Wall Street li lumela hore li-stock tse nang le tebello ea kholo e feteletseng li bontša tse ling tsa li-stocks tse matla ka ho fetisisa.Monyetla ona oa kholo o ka nqane ho sekhahla sa hona joale, 'me mabitso ana a tla fumana meputso e mengata ka 2020 le ho feta.Seo se boletse, ho bolela bonyane, ho fumana li-stocks tse oelang sehlopheng sena ho ka ba thata.Bahlahlobisisi ba lumela hore leano le le leng ke ho khutlela morao, ho sheba setšoantšo se seholo, le ho tsepamisa maikutlo ho lik'hamphani tse nang le khōlo ea nako e telele e itšetlehileng ka katleho e tsotehang ea selemo le selemo.Ha re ntse re hopola sena, re sebelisitse database ea TipRanks ho tsebahatsa li-stock tse tharo tse neng li lekantsoe haholo ke bahlahlobisisi.Li-stock tse tharo li fihletse kholo e kholo ka 2020 mme li ikemiselitse ho tsoela pele ho hloa.Pennsylvania National Game Company (PENN) Taba ea pele, re na le Pennsylvania National Game Company, e leng beng le ho tsamaisa litsi tsa lipapali le tsa mabelo le likhoebo tsa lipapali tsa video United States.Lebitso le nyolohile ka 146% ho fihlela joale, empa bahlahlobisisi ba bang ba Wall Street ba lumela hore ho ntse ho e-na le mafura a mangata ka tankeng.PENN e sa tsoa phatlalatsa liphetho tsa kotara ea boraro esale pele, tse fetang tebello.Khamphani e lebelletse hore phaello ea phaello bakeng sa kotara e eketsehe ka lintlha tse fetang 900, mme EBITDAR e fetotsoeng e tla hola ka 5% selemo le selemo, leha lekeno le theohile ka 10% selemo le selemo.Setsebi sa linaleli tse hlano Joseph Greff o ile a bolella bareki hore "JP Morgan Chase" o itse: "Ho hlaphoheloa ha indasteri ea lipapali tsa libaka ka May / June ho ile ha tsoela pele ho fihlela kotara ea boraro, 'me chelete e kenang e ne e le molemo ho feta kamoo ho neng ho lebeletsoe kateng.Hang ha tlhoko e hatelitsoeng Kamora ho khutlela setloaeling, mme kaha ts'ebetso ea COVID e fetileng e ntlafetse, litšenyehelo tsa ts'ebetso ha li so ka li nyoloha.Pele re ne re nahana hore sekhahla sa kholo se theohile. ”Ha a se a buile joalo, Greif o ile a lumela hore ho latela ts'ebetso e ntle ea theko ea setoko, bahlahlobisisi ba bang ba tlohetse maemo a morao ".Leha ho le joalo, o ntse a lumela hore "bohlokoa le ts'usumetso ea bokamoso".Bahlahlobisisi ba ile ba re: “…Ho na le ho qabana maikutlo ho batsetedi.Re lumela hore sena se phetse hantle bakeng sa li-stock 'me se batla se hlokahala hore lihlahisoa li tsoele pele ho phahama;re lumela hore bo-ramatsete ba setso sa papali ea papali ha ba so hlorisoe ka botlalo.Re lumela hore bo-ramatsete ba na le lipelaelo mabapi le bokhoni ba PENN ba ho qothisana lehlokoa le DraftKings, Fanduel, Caesars Entertainment, MGM/GVC, joalo-joalo. PENN e lekanyelitsoe ho leka-lekana ea tekanyo ea leqephe e ka lefella litšenyehelo tsa ho fumana bareki ba pele ba ho becha lipapaling, empa rea ​​lumela , Ka lebaka la hore tekano ea morao tjena. ho bokella chelete ho phahamisitse lidolara tse limilione tse 950, kotsi ea tlhōlisano ena e fokotsehile ka tekanyo e utloahalang.”Habohlokoa le ho feta, PENN e sa tsoa tsebisa sesebelisoa sa ho becha sa Barstool Sports Pennsylvania.Greff o bitsitse tokollo ena ea pele "e khothatsang mabapi le tšebeliso ea chelete le thekiso," mme e ipakile "monyetla oa mokhoa o ikhethileng oa ho fumana karolo."Ho feta moo, lebelo la Barstool Sportsbook le ntse le eketseha.Habohlokoa le ho feta, Greff o lumela hore maemo a hona joale a ho becha le iGaming a tšoana le ho phahama ha limmaraka tsa libaka lilemong tsa bo-1990, ha linaha tse nang le likhaello tsa lichelete li fetohela mehloling e mecha ea chelete, joalo ka lipapali tsa likepe tsa linoka ho thusa ho koahela lichelete tsa bona.khaello.Mabapi le taba ena, mohlahlobisisi o itse: “Re lumela hore naha ka ’ngoe e na le litebello tse batlang li lekana bakeng sa USSB le iGaming, ’me PENN e tla ba e ’ngoe ea bahlōli.Re rata mokhoa oa ho bapala oa lipapali / lipapali tsa ho becha / iGaming US mme re bona sebaka sa kholo..”Haele hantle, ha ho makatse hore ebe Grave o ile a sala le Lipoho.Ntle le ho fana ka tekanyo ea "boima bo feteletseng", o ile a boela a beha sepheo sa theko ea $ 83 bakeng sa thepa.Haeba sepheo sena se finyelloa nakong ea likhoeli tse leshome le metso e 'meli tse tlang, batseteli ba ka fumana phaello ea 32%.(Ho shebella rekoto ea lipina tsa Greif, tlanya mona.) Wall Street kaofela e reng?Ho ile ha fanoa ka litheko tse robong, tse tharo le thekiso e le 'ngoe likhoeling tse tharo tse fetileng.Ka lebaka leo, PENN e fumane tekanyo ea tumellano ea "theko e mahareng".Ho itšetlehile ka tekanyo ea karolelano ea theko ea $ 76.77, theko ea theko e ka 'na ea phahama ka 22% selemong se tlang.(Sheba Penn National Gaming stock analysis on TipRanks.) Redfin (RDFN) Redfin e qalile ka sebaka sa ho batla se thehiloeng 'mapeng 'me ea atolosa lihlahisoa tsa eona ho etsa lipapali tsa malapa, li-debuts le mekhoa ea ho amohela batho ka potlako le ka bonolo.Wall Street, batho ba bang ba nahana hore lebitso ha le bue feela ka keketseho ea tlhoko ea COVID, mme phaello ea eona ea selemo le selemo ea 113% ke qalo feela.Leha RDFN e lahlile ponelopele e matla ea kotara ea boraro, batseteli ba ile ba nyahamisoa ke sephetho.Jake Fuller oa BTIG o bontšitse hore theko ea thepa e ka 'na ea theoha hobane "litebello li phahame' me keketseho e itekanetseng ea chelete e kenang e ka ba 2%" 'me "batseteli ba potlakileng ba atisa ho putsa morethetho o tsamaisoang ke molumo, ha RDFN e hlile e salla morao ho tebello ena."Fuller o lumela hore RDFN ha se sepheo sa batho ba bangata, e leng se supang hore batseteli ba kanna ba se bone phatlalatso ea meputso.Leha ho le joalo, o nahana hore Wall Street e kanna ea fosa karolo ea bohlokoa ea puzzle.Setsebi sa linaleli tse hlano se boletse: "Se ka hlokomolohuoang mona ke hore RDFN e ekelitse sekhahla sa khomishene ntle le tšusumetso e kholo ho sekhahla sa phetoho, se tla ntlafatsa haholo pono ea phaello e kholo ea RDFN."Ho fihlela sena, o tla etsa phaello ea 2021 e lebelletsoe ho eketseha ka 47%.Ha re shebisisa lintlha tse qaqileng tsa kotara, RDFN e bile le tlhokahalo e matla mme lekeno la lits'ebeletso tsa thekiso ea matlo le meaho le ile la hola ka 36% selemo le selemo.Sephethephethe sa marang-rang le palo ea litšebelisano le tsona li eketsehile khoeli le khoeli.Leha ho le joalo, hoa lokela ho hlokomeloa hore ho phahama ho tsamaisoa ke chelete ea khoebo ka 'ngoe.Fuller o itse: "Sena se bohlokoa hobane se bontša hore sekhahla se lebelletsoeng sa khomishene se tla kenya letsoho qetellong."Ho ea ka lipalo-palo tsa rona, lekeno la lits'ebeletso tsa meaho ho tloha ho 1.68% ea GTV karolong ea boraro ea 2019 le kotara ea bobeli ea 2020 1.78% e nyolohetse ho 1.85% kotareng ea boraro ea 2020. sephethephethe se seholo sebakeng sena.Leha ho le thata ho lekola ho phehella ha tlhokeho, keketseho ea litheko le mekha e betere ea phaello e lokela ho tšoarella "Fowler o ile a fana ka maikutlo.Tumellanong le tšepo ea hae, Fuller o ile a tšehetsa lipoho, a pheta tekanyo ea ho reka le theko ea thepa e shebiloeng ea $65.Sepheo sena se bontša tšepo ea hae ho bokhoni ba RDFN ba ho eketseha ka 45% selemong se tlang.(Ho bona rekoto ea pina ea Fuller, tlanya mona.) Ha u fallela libakeng tse ling tsa Wall Street, maikutlo a ile a arohana le ho feta.Likhoeling tse tharo tse fetileng, ho ile ha ajoa tse 6 tsa ho reka, tse 5 le tse 1 tse rekisoang.Ho latela Wall Street, RDFN ke theko e mahareng.Palo e tloaelehileng ea theko ea $ 50 e bolela 11% holimo.(Sheba Redfin stock analysis on TipRanks) Vertiv Holdings (VRT) Joalo ka e 'ngoe ea li-hardware, software le bafani ba lits'ebeletso tse etelletseng pele lefats'eng, Vertiv Holdings e thusitse ho khothaletsa mmaraka o hokahantsoeng oa litsamaiso tsa dijithale, moo palo e kholo ea lintho tse hlokahalang. ho fetisoa, ho hlahlojoa, ho sebetsoa le ho bolokoa.Wall Street e boletse hore e nyolohile ka 71% ho fihlela joale selemong sena, mme ho ka ba le melemo e mengata.Esita le haeba theko ea theko e phahama haholo, setsebi sa Wolfe Research Nigel Coe se ntse se lumela hore boemo ba kotsi / moputso bo molemo.O ile a hlalosa: “Re lumela hore Vertiv ke mofuta o sa tloaelehang o ka hohelang bo-ramatsete ba bangata: k’hamphani ea khōlo e mahareng e ka fanang ka khōlo e khahlang ea phaello ka theolelo ’me e tlas’a boikarabelo ba sehlopha se phahameng sa batsamaisi.”Ha ho tluoa tabeng ea VRT Tseleng ea kholo, limmaraka tsa eona tse ka sehloohong ke litsi tsa data le mehala ea puisano.Libaka tsena ke libaka tseo Coe a lebeletseng ho finyella kholo ka 2020 le 2021, hammoho le mefokolo ea nako e telele e tlisoang ke keketseho e tsoelang pele ea matla a data le ntlafatso ea 5G.Ho feta moo, ka ho susumetsoa ke boiteko ba ho boloka litšenyehelo tse tsitsitseng kamehla ka lintlafatso tse fapaneng tsa ts'ebetso le ho fokotsa ho rarahana ha mokhatlo, batsamaisi ba hlalositse mokhoa oa ho holisa phaello ho fihla ho lintlha tse 500."Ena ke script e atlehileng ho romelloa ke molula-setulo ea ka sehloohong David Cote nakong ea mosebetsi oa hae Honeywell, e leng se re kholisang hore mangolo a tšoanang a ka sebelisoa Vertiv," Cohen o itse.Ho bohlokoa ho hlokomela hore VRT e ile ea ikhula kotareng ea bobeli ea 2020, ka mokoloto oa kakaretso o ka bang $ 2.1 bilione le mokoloto oa kakaretso / EBITDA o fihlang makhetlo a 4.2.Esita le qetellong ea mefuta ena, Coe o lumela hore tekanyo ea tekanyo e ka 'na ea fokotseha ka potlako.Ho finyella sena, o nka hore ka 2023 tekanyo ea likoloto / EBITDA e habeli, joale chelete e setseng e tla fihla ho lidolara tse limilione tse likete tsa US."Hajoale ha re nahane hore Vertiv ke pale e hlakileng ea phetisetso ea chelete, empa sena se ka hlaha ka nako ea 2022/23-ehlile re ka bona mesebetsi ea ho fumana thepa ho ntlafatsa bokhoni ba eona lebaleng la kabo ea motlakase le sekhahla sa DCIM.Dikgetho tse ding tse ka bang teng di kenyeletsa ho fediswa ha diwaranti tsa tjhelete (tsena hajwale di bonahala dipalong tsa rona tse hlapolotsweng tsa diabo) le tsela eo meputso e abuwang ka yona, e leng ho tla hodisa monyetla wa ho ba beng ba setheo.Hape re ke ke ra iphapanyetsa taba ea hore lisebelisoa tse ngata tse kholo tsa motlakase Boemong ba litšebelisano tsa maano tse thehiloeng ke barupeluoa ba mebaraka, barupeluoa bana ha se barupeluoa ba bohlokoa setsing sa data. "Ntho e 'ngoe le e 'ngoe eo VRT e e entseng e khothalelitse Coe ho pheta lintlha tsa eona tsa boleng bo holimo.Ha a ntse a letsetsa likhetho, o ile a beha sepheo sa theko ea $ 23, e leng se bolelang hore ho na le monyetla o moholo oa 22%.(Ho sheba tlaleho ea Coe, tobetsa mona) Na bahlahlobisisi ba bang ba lumellana?ke.Likhoeling tse tharo tse fetileng, ke lintlha tse 4 feela tsa "reka" tse hatisitsoeng.Ka hona, molaetsa o hlakile: VRT ke theko e matla.Ho fanoe ka hore theko e tloaelehileng ea sepheo ke $ 20.75, theko ea theko e ka 'na ea phahama ka 10% selemong se tlang.(Sheba tlhahlobo ea stock ea Vertiv Holdings ho TipRanks) Boitlhotlhollo: Maikutlo a hlahisitsoeng sengolong sena ke a mohlahlobisisi ea ka sehloohong.Litaba ke tsa litšupiso feela.Pele u etsa letsete leha e le lefe, ho bohlokoa haholo ho iketsetsa tlhahlobo ea hau.
Microsoft, Apple, Alphabet, Facebook, Amazon, AMD, Caterpillar, Comcast, GE, Ford, Pfixer, Visa, UPS, Exxon Mobil, Twitter le lik'hamphani tse ling li tlalehile liphello tsa bona tsa kotara ea boraro.
Sethala se secha sa ho arolelana bakeng sa li-SME tsa Hong Kong- "HSBC Airport" e o hokahanya le tlhahisoleseling le liketsahalo tse fapaneng tsa khoebo
Bekeng e qetellang ka la 22 Mphalane, litefiso tsa mortgage li ile tsa theoha haholo.Ho lebelletsoe hore lipolotiki tsa COVID-19 le Amerika li tla tsoela pele ho ba le tšusumetso bekeng ena.
Trifecta Stocks e tla khetholla li-bearish stocks ka Laboraro le leng le le leng, 'me ho ka' na ha e-ba le menyetla e meng e thahasellisang ea lichelete nakong e khutšoanyane.Re sebelisa tlhahlobo ea tekheniki ea lichate tsena tsa stock, 'me moo ho loketseng, ho ipapisitsoe le liketso tsa morao-rao tsa TheStreet's Quant Ratings le lintlha, re hlakotse mabitso a mahlano.Leha re ke ke ra nahana ka tlhahlobo ea mantlha, re ts'epa hore sengoloa sena se tla fa batseteli ba ratang metšoasong sebaka se setle sa ho qala mosebetsi oa sekolo o eketsehileng ka lebitso.
Kamora lilemo tse ngata tsa ho sebetsa khase ea shale ea Amerika, Chevron e becha bokamoso ba eona ba khase ea tlhaho tikolohong e sa tsitsang ea Middle East, 'me litsebi tsa matla li bile hlokolosi ka nako e telele.Qeto ea makhaola-khang ea khamphani Michael Wirth e tšehetsoa ke bethe ea hore Bochabela bo Hare bo kena nakong ea poelano, e leng se tla etsa hore e be khetho e nepahetseng bakeng sa ho ntšoa ha khase ea tlhaho, kaha ho lebeletsoe hore e be theko e tlaase ho feta mafura a theko e tlaase le a hloekileng.Tlhokahalo e tla feta oli.Leano le lecha ke hore k'hamphani e khothaletse litšebelisano tse ncha tsa khase ea tlhaho Egepeta, Israel le Qatar, ha e ntse e fokotsa tšebeliso ea chelete lipatlisisong tsa shale United States.