Idatha entsha evela kuphononongo oluqhubekayo lweSigaba se-3 ichaza ngakumbi ukusebenza kweVUMERITY® (iDilosimil fumarate) kunye nokuphucula ukunyamezela kwesisu.
Xa kuthelekiswa ne-Ocrevus® (ocrelizumab), ezona zinto zifunyanisiweyo zivavanye umgangatho wezibonelelo zobomi ezinxulumene ne-TYSABRI® (natalizumab)
Ezinye izinto ezifunyanisiweyo zokwenyani zinika ingxelo ngezibonelelo ezilungileyo ze-PLEGRIDY® (peginterferon beta-1a) kunye ne-AVONEX® (i-interferon beta-1a) kwizigulane ezisebekhulile ezine-multiple sclerosis.
Cambridge, Massachusetts, Septemba 11, 2020 (Iindaba zeGlobal)-Biogen Inc. (NASDAQ: BIIB) namhlanje ibhengeze idatha entsha eqaqambisa i-industry-leading multiple sclerosis (MS) Ukusebenza kunye nokhuseleko lokudibanisa unyango.Ezi nkcukacha ziya kuboniswa ngexesha lentlanganiso yesibhozo edibeneyo ye-MSVirtual2020, i-American Multiple Sclerosis Treatment and Research Committee kunye ne-European Multiple Sclerosis Treatment and Research Committee (ACTRIMS-ECTRIMS), eya kubanjwa ukususela ngoSeptemba 11 ukuya kwi-13, i-2020.
"Igosa lezoNyango eliyiNtloko ye-Biogen uMaha Radhakrishnan, MD, uthe: "I-Biogen inebhongo kuba sizimisele ukusombulula imingeni engxamisekileyo kunye nexesha elide elijongene nezigulana ze-MS."Idatha esiyinikezelayo kwi-ACTRIMS-ECTRIMS ibalaselisa iziphumo eziphuculweyo.Ipotifoliyo yethu yemveliso ye-MS ebanzi iyaqhubeka nokusebenzela izigulana ezine-MS ebuyela umva, kungakhathaliseki ukuba ziphi na kwinkqubo yonyango, kunye nophando lwethu oluqhubekayo kunye nophuhliso lweTyalo-mali ekuphuhliseni abaviwa bamachiza asebenzayo.”
Idatha yeSigaba esitsha se-3 ibonakalisa ngakumbi ukusebenza kwe-VUMERITY® (i-Dilosimide fumarate) kunye nokunyamezela kwe-GI echazwe ngesigulana.Idatha entsha evela kwinkqubo yeklinikhi yeSigaba sesi-3 se-VUMERITY ngakumbi ichaza unyango lwamva nje lwe-Biogen lonyango lwe-fumarate yomlomo Ukusebenza kunye nokhuseleko.Xa kuthelekiswa ne-TECFIDERA® (i-dimethyl fumarate) (n = 251) kunye nenkxaso, iziphumo ze-EVOLVE-MS-2 yeeveki ezintlanu zomeleze ukunyamezela kwesisu (GI) kwezigulane ezivavanyiweyo ezinxulumene nonyango lwe-VUMERITY Ukubaluleka kweklinikhi yokwamkelwa (n = 253) iphucula impembelelo yayo kumgangatho wobomi bezigulane ezine-MS eziphindaphindiweyo.Abathathi-nxaxheba kuphononongo oluthatha i-VUMERITY bathi abafane baphuhlise iimpawu zesisu eziphazamisana nemisebenzi yemihla ngemihla okanye ezinxulumene nokungabikho komsebenzi, kwaye kukho amachiza ambalwa asetyenziselwa ukunyanga iimpawu zesisu.
Uhlalutyo lokuhlola oluqhubekayo lwe-EVOLVE-MS-1 luvavanye umphumo we-VUMERITY ekutshintsheni umthamo wengqondo kunye nezinye izibonakaliso zeklinikhi kubantu abane-MS ephindaphindiweyo (n = 365) baphathwa ukuya kuthi ga kwiminyaka emibini.Izifundo ezahlukeneyo zibonise ukuba ukuhla komthamo wengqondo kunokunxulumana nokuphazamiseka kwengqondo, ukukhubazeka ngokomzimba kunye nokwehla komgangatho wobomi kwizigulana ze-MS.1,2, idatha ye-EVOLVE-MS-1 ibonisa:
Izinga lonyaka lokutshintsha umthamo wengqondo yabathathi-nxaxheba abafumene unyango lwe-VUMERITY iminyaka emibini lwalufana nolo lwabantu abasempilweni.nge
Ngokumalunga ne-90% yezigulane ezifumana unyango lwe-VUMERITY alukho ukuqhubela phambili kokukhubazeka okuqinisekisiweyo, kwaye malunga ne-84% ayinakuphindaphinda kwiminyaka emibini.
Idatha yokugqibela evela kwiSigaba se-3 sophando lwe-ENDORSE nayo iya kuboniswa kwinkomfa, ebonisa ngakumbi ukuphumelela okuqhubekayo kunye nokhuseleko oluchazwe kakuhle lwe-TECFIDERA kwizigulane ukuya kwi-13 iminyaka.
Idatha yokwenyani evela kuhlalutyo olwahlukileyo lwe-MS ephindaphindiweyo ibonisa ukuba nge-MS PATHS (i-Partner Advance Technology kunye ne-Health Solutions), i-TYSABRI® (natalizumab), i-PLEGRIDY® (i-pegylated interferon beta-1a) kunye ne-AVONEX® (i-interferon beta-1a) iziphumo ziye zaphucuka., I-Biogen isebenzisana namaziko e-MS ahamba phambili eYurophu nase-United States ukuvelisa idatha esemgangathweni, ephezulu evela kwiindawo ezahlukeneyo zezigulane ze-MS zehlabathi.Ukuza kuthi ga ngoku, ngaphezu kwe-17,000 yezigulane ezithathe inxaxheba kwi-MS PATHS.Idatha efunyenwe kunyango kwindawo yokwenyani ixhasa iziphumo eziphuculweyo ezinxulumene ne-TYSABRI, PLEGIDYY kunye ne-AVONEX.Iziphumo zohlalutyo olwahlukileyo kwidatha ye-MS PATHS zibonisa:
Kuthelekiso lokuqala lwerejimeni ye-MS PATHS eqhelekileyo yemagnethi yomfanekiso wemagnethi (MRI), utshintsho ngexesha elongeziweyo lexesha lokudosa (EID; n = 85) ye-natalizumab yafaniswa ne-MRI yobuchopho evunyiweyo (ithetha ukulandelwa kwe-0.8 iminyaka).Kanye kwiiveki ezine (Q4W; n = 569).Uhlalutyo alubikanga mahluko abalulekileyo kwisifo esitsha se-T2, izifo eziguquguqukayo ze-T2 kunye nezinga le-brain atrophy.Umahluko kwiiskena ze-MRI kunye neeprothokholi zokufumana kwiinkqubo zeklinikhi zenza uthelekiso lweziphumo ze-MRI yobuchopho lube ngumngeni.Izifundo ezininzi zehlabathi lokwenyani zibonise ukuba ukusebenza kwe-natalizumab EID kuyafana nedosi evunyiweyo ye-Q4W.I-3-7Biogen iyaqhubeka nokuvavanya ukuphumelela, ukhuseleko kunye nokunyamezela kwe-natalizumab EID ngokusebenzisa uvavanyo olulindelekileyo lwe-NOVA (NCT03689972), kwaye kutshanje ingenise isicelo sokulawulwa kwe-subcutaneous igunya lokulawula.Ukuba ivunyiwe, iya kubonelela ngeendlela ezininzi zolawulo lweTYSABRI.
Ngokutsho kwe-Neuro-QoL (uMgangatho woBomi kwiZifo zeNervous System), unyango lwe-TYSABRI luphuculwe ngakumbi kumgangatho othile wobomi kune-Ocrevus® (ocrelizumab).Kucazululo lweqela elingaphantsi lezigulane ezihambelanayo eziphathwe nge-TYSABRI okanye i-Ocrevus, kwabonwa ukuba i-9 kwi-12 ye-Neuro-QoL imimandla kwizigulana eziphathwe nge-TYSABRI ziphuculwe kakhulu (n = 144).I-4 kwi-12 domains iphuculwe kakhulu (n = 502)).Lilonke, izinga lokuphucula lonyaka le-TYSABRI liphezulu kunelo le-Ocrevus, kwaye umahluko obonakalayo ubonwa kwimiba emithathu: impembelelo entle kunye nokuba sempilweni, ukwaneliseka ngeendima zentlalo kunye nemisebenzi, kunye nokuphazamiseka kokulala.
Xa kuthelekiswa nezigulane ze-MS ezingaphantsi kweminyaka engama-60 ubudala (n = 729), iziphumo zekliniki zezigulane ze-MS ezingaphezu kweminyaka eyi-60 ubudala (n = 286) zibonise ukuba kumaqela omabini ubudala, zombini i-PLEGRIDY kunye ne-AVONEX inokubonelela ngokusebenzayo Izibonelelo zonyango.Idatha ibonisa ukuba uvavanyo lwe-speed speed test (PST) kunye novavanyo lokuva ubunzima (CST) lwamaqela amabini eminyaka luphuculwe ngaphezu konyaka omnye.Ukongeza, uninzi lwabathathi-nxaxheba kuwo omabini amaqela obudala abazange baphinde babuyele kwiminyaka emibini.
Idatha evela kwiSigaba soku-1 sophononongo lwe-BIIB091 ixhasa unyango oluqhubekayo lwe-MSBiogen, kwaye idatha evela kwiSigaba 1 sokufunda se-BIIB091 nayo inikezelwe.I-BIIB091 yinto ekhethiweyo, eguquguqukayo (engekho-covalent) encinci ye-molecule inhibitor yomsebenzi womlomo we-Bruton's tyrosine kinase (BTK) Agent.Idatha ivavanye ukhuseleko, ukunyamezeleka, i-pharmacokinetics kunye ne-pharmacodynamics yedosi yomlomo enye kunye neyodwa ekhulayo kwizifundo zabantu abadala abanempilo.Ukuvinjelwa kwe-BTK okukhethiweyo kunokuba luncedo kunyango lwe-MS ngokuthintela ukusebenza kweeseli ze-B kunye neeseli ze-myeloid ngaphandle kokunciphisa iiseli zomzimba.
Unikezelo lwedatha kwi-ACTRIMS-ECTRIMS: Qaphela: Zonke iinkcazo-ntetho zepowusta ze-MSVirtual2020 ziya kufumaneka kwi-intanethi ngo-8 AM ngeXesha laseMpuma ngoLwesihlanu, nge-11 kaSeptemba 2020.
Xa kuthelekiswa ne-dimethyl fumarate kwi-EVOLVE-MS-2, ukunyamezela kwe-GI ephuculweyo ye-Diroximel fumarate inxulumene kakhulu nokubaluleka kwekliniki yomgangatho wobomi (iPoster 0214)
Impembelelo ye-Diroximel fumarate ekutshintsheni umthamo wobuchopho kunye nokuqhubela phambili kokukhubazeka kubantu abadala abane-EVOLVE-MS-1 i-relapsing-remitting multiple sclerosis (Ipowusta P0205)
Ukhuseleko kunye nokusebenza kwezigulane eziphathwe nge-dimethyl fumarate kwaye zilandelwe iminyaka eyi-13: iziphumo zokugqibela ze-ENDORSE (iqonga FC02.05-ngeCawa, ngoSeptemba 13th 1: 48-2: 00 i-US Eastern Time)
Iziphumo zeradiology yezigulane ezineedosi zekhefu ezandisiweyo ze-Natalizumab azahlukanga kwiidosi zekhefu eliqhelekileyo kwi-MS PATHS (Ipowusta P0360)
Impembelelo ye-Natalizumab kuMgangatho woBomi kwiQela lokwenyani leZigulana ze-Multiple Sclerosis: Iziphumo ze-MS Pathway (Ipowusta ye-P1036)
Iimpawu kunye neziphumo zeklinikhi zezigulane ze-MS ezisebekhulile ezine-Peginterferon Beta-1a okanye i-interferon ye-intramuscular Beta-1a kunyango lwe-MS indlela (iPoster P0843)
Isigaba se-1 sophando lwe-BIIB091 (i-Bruton's tyrosine kinase (BTK) inhibitor) kubathathi-nxaxheba abadala abanempilo: iziphumo zokuqala (ipowusta P0186)
Malunga ne-VUMERITY® (i-Dilosemate Fumarate) I-VUMERITY yi-fumarate yomlomo enesakhiwo sekhemikhali esahluke ngokupheleleyo kwi-TECFIDERA® (i-Dimethyl Fumarate), evunyiweyo e-United States yonyango lwe-multiple sclerosis kubantu abadala Iindlela eziphindaphindiweyo zesifo ziquka i-syndromes eyedwa yeklinikhi, izifo eziqhubekayo eziphindaphindiweyo kunye nezifo eziqhubekayo zesekondari ezisebenzayo.Emva kokungena emzimbeni, i-VUMERITY iguqulwa ngokukhawuleza ibe yi-monomethyl fumarate, i-metabolite efanayo esebenzayo ye-dimethyl fumarate.
I-VUMERITY inqatshelwe kwizigulane ezingadibaniyo ne-Diroximel fumarate, i-dimethyl fumarate okanye nayiphi na i-excipients ye-VUMERITY;kunye nezigulana ezithatha i-dimethyl fumarate.Iziphumo ezibi kakhulu ze-VUMERITY zisekwe kwidatha ye-dimethyl fumarate (i-metabolite efanayo esebenzayo njenge-VUMERITY), kubandakanywa ukusabela kokwaliwa kunye ne-angioedema, i-progressive multifocal leukoencephalopathy, ebuchotsheni obungenelelayo obunqabileyo Usulelo lwentsholongwane lunxulumene nokufa okanye ukugula okuqatha.Ukukhubazeka, ukunciphisa i-avareji ye-lymphocyte count kunyaka wokuqala wonyango, i-shingles kunye nezinye izifo ezinzulu, umonakalo wesibindi kunye nokugungxula.Iziganeko ezimbi eziqhelekileyo ezifunyenwe kusetyenziswa idatha esuka kwi-dimethyl fumarate (ene-metabolite efanayo esebenzayo njenge-VUMERITY) yayigungxula, intlungu yesisu, isisu, kunye nesicaphucaphu.
Nceda ucofe apha ukuze ufumane ulwazi olubalulekileyo lokhuseleko kunye nolwazi olupheleleyo lommiselo, kuquka nolwazi lwesigulana seVUMERITY eUnited States.
Malunga ne-TECFIDERA® (i-dimethyl fumarate) I-TECFIDERA yindlela yonyango yokubuyisela i-multiple sclerosis (MS) kubantu abadala.Lelona chiza limiselweyo lokubuyela umva i-MS ehlabathini.Kuye kwangqinwa ukunciphisa izinga lokuphindaphinda kwe-MS kunye nokucotha.Iqhubela phambili ekukhubazekeni kwaye ichaphazela inani lezilonda zobuchopho ze-MS, kwaye ingqina ukuba uphawu lokhuseleko lwezigulane ezine-MS ebuyeleyo lulungile.I-TECFIDERA ivunyiwe kumazwe / imimandla ye-69 kwaye iye yaphathwa kwizigulane ze-475,000, oku kuthetha ukuba ngaphezu kwe-950,000 yesigulane-iminyaka yezigulane ezisebenzisayo kunye nokumisela i-TECFIDERA.Kwezi, izigulane ezingama-6,335 (iminyaka eyi-14,241 yesigulana) zivela kulingo lwezonyango8.
I-TECFIDERA ayivumelekanga kwizigulana ezingadibaniyo ne-dimethyl fumarate okanye naziphi na izinto ezisiza kwi-TECFIDERA.Iziphumo ebezingalindelekanga ezimandundu ziquka ukuchasana nokwaliwa kunye ne-angioedema, kunye neemeko ze-progressive multifocal leukoencephalopathy (usulelo olungenelelayo lobuchopho olungenelelayo olunxulumene nokufa okanye ukukhubazeka okuqatha) ziye zabonwa kwizigulane ze-TECFIDERA ezine-lymphopenia yexesha elide, nangona indima ye-lymphopenia ingaqinisekanga kwezi meko. .Ezinye iziphumo ebezingalindelekanga ezimandundu ziquka ukwehla komndilili wesibalo se-lymphocyte kunyaka wokuqala wonyango, iishingles kunye nolunye usulelo olumandundu, ukonakala kwesibindi kunye nokugungxulwa.Kulingo lwezonyango, ezona ziganeko zibi zixhaphakileyo ezinxulumene ne-TECFIDERA yayikukugungxula, iintlungu zesisu, urhudo kunye nesicaphucaphu.
Nceda ucofe apha ukuze ufumane ulwazi olubalulekileyo lokhuseleko kunye nolwazi olupheleleyo lwamayeza, kuquka nolwazi lwesigulana lwe-TECFIDERA e-United States, okanye undwendwele iwebhusayithi yemveliso kwilizwe/ummandla wakho.
Malunga ne-TYSABRI® (natalizumab) I-TYSABRI lunyango olusebenzayo lokuphinda ubuyele kwi-multiple sclerosis (RMS), engasetyenziselwa ukubuyisela i-MS kubantu abadala.Ulingo lwezonyango lubonakalise ukuba olu nyango lunokucothisa ukuqhubela phambili kokukhubazeka ngokomzimba kunye nokunciphisa Ukwenziwa kwezilonda ezitsha zengqondo kunye nokunciphisa ukuphindaphinda.I-TYSABRI yamkelwe kumazwe/imimandla engama-80.Ngokweemvavanyo zeklinikhi kunye nedatha kagqirha, i-TYSABRI ifumene unyango lwe-TYSABRI kubantu abangaphezu kwama-213,000 kwihlabathi liphela, ngaphezulu kwe-835,000 yeminyaka yesigulana yamava.9
I-TYSABRI yonyusa umngcipheko we-progressive multifocal leukoencephalopathy (PML), usulelo lwentsholongwane olungenelelayo olunqabileyo lwengqondo oluye lwayanyaniswa nokufa okanye ukukhubazeka okuqatha.Umngcipheko onyusa umngcipheko we-PML kubukho be-anti-JC virus antibodies, ukusetyenziswa kwe-immunosuppressive agents kunye ne-TYSABRI yonyango olude.Izigulane ezinemingcipheko emithathu zinomngcipheko ophezulu we-PML.Xa uqala kwaye uqhubeleka nonyango nge-TYSABRI, oogqirha kufuneka baqwalasele ukuba izibonelelo ezilindelekileyo ze-TYSABRI zanele na ukuphelisa lo mngcipheko.
I-TYSABRI ikwanyusa umngcipheko wokuphuhlisa i-encephalitis kunye ne-meningitis ebangelwa yi-herpes simplex kunye ne-varicella-zoster virus.Ngokweengxelo, izigulana ze-MS ezifumana i-TYSABRI zineemeko ezinzima, ezibeka ubomi esichengeni kunye neemeko ezibulalayo emva kwemarike.Kwimeko ye-post-marketing, kukho kwakhona umonakalo obalulekileyo weklinikhi wesibindi, kubandakanywa ukungaphumeleli kwesibindi esinzima esifuna ukutshintshwa.Ezinye izehlo ezimbi kakhulu ezenzeke kwizigulana eziphathwe nge-TYSABRI ziquka ukusabela kwe-hypersensitivity (ezifana nokuchasana nomzimba) kunye nosulelo, kubandakanywa usulelo olungenelelayo kunye nolunye usulelo oluyi-atypical.
Nceda ucofe apha ukuze ufumane ulwazi olubalulekileyo lokhuseleko, kuquka nezilumkiso ezisebhokisini, kunye nolwazi olupheleleyo olubhalwe ngugqirha, kuquka ne-US TYSABRI isikhokelo samayeza, okanye undwendwele iwebhusayithi yemveliso kwilizwe/ummandla wakho.
Malunga ne-PLEGRIDY® (i-pegylated interferon β-1a) I-PLEGRIDY yi-interferon engaphantsi kwe-pegylated, kanye emva kweeveki ezimbini, kwifom ephindaphindiweyo ye-multiple sclerosis (MS) kubantu abadala, eyona ndlela ixhaphakileyo ye-MS.Ifomu eqhelekileyo.I-PLEGRIDY okwangoku ivunyiwe kumazwe / imimandla ye-60, kuquka i-United States, i-Canada, i-Australia kunye ne-Switzerland, kunye ne-European Union yonke.Ngokwedatha kagqirha, phantse abantu abangama-57,000 kwihlabathi liphela baye bafumana unyango lwe-PLEGRIDY, ngaphezu kwe-107,000 yesigulana-iminyaka yamava.I-10Biogen iyaqhubeka nokusebenza ukubonelela nge-PLEGRIDY kwamanye amazwe / imimandla emhlabeni jikelele.
Ukusebenza kunye nokhuseleko lwe-PLEGRIDY kuxhaswa lolona phando lukhulu lubalulekileyo, olusebenzise unyango lwe-interferon kwizigulana ezine-MS ezibuyisela umva.Kwizifundo zeklinikhi, kuye kwangqinwa ukuba i-PLEGRIDY inokunciphisa kakhulu izinga lokuphindaphinda kwe-MS, icothise ukuqhubela phambili kokukhubazeka kunye nokunciphisa inani lokulimala kwengqondo kwi-MS.Kwangaxeshanye, kuye kwangqinwa ukuba ukhuseleko lwezigulana ezine-MS ebuyele umva lulungile.Imiphumo emibi echazweyo ibandakanya iingxaki zesibindi, kubandakanywa ukungaphumeleli kwesibindi kunye nokwanda kwe-enzymes yesibindi;ukudakumba okanye iingcinga zokuzibulala;ukuchasana kakhulu;iingxaki zentliziyo, kuquka ukungaphumeleli kwentliziyo;izifo ze-autoimmune;ukuncipha kweeseli ezimhlophe zegazi okanye ukubalwa kweeplatelet;kunye nokuxhuzula.Kulingo lwezonyango, ezona ziganeko zibi zixhaphakileyo ezinxulunyaniswa ne-PLEGRIDY yayikukusabela kwendawo yokutofa kunye neempawu ezifana nomkhuhlane.Uluhlu lweziganeko ezimbi lunokufumaneka kwileyibhile epheleleyo yePLEGRIDY yemveliso yelizwe ngalinye elaziwayo.
Nceda ucofe apha ukuze ufumane ulwazi olubalulekileyo lokhuseleko kunye nolwazi olupheleleyo lokumisela, kuquka iUS PLEGRIDY izikhokelo zonyango lwechiza, okanye undwendwele iwebhusayithi yemveliso kwilizwe/ummandla wakho.
Malunga ne-AVONEX® (I-Interferon beta-1a) I-AVONEX yenzelwe ukubuyisela i-MS, kwaye ivunyiwe kumazwe angaphezu kwama-90.Ngokutsho kwedatha ye-prescription, abantu abangaphezu kwe-580,000 emhlabeni jikelele baye bafumana unyango lwe-AVONEX, ngaphezu kwe-2.6 yezigidi zesigulane-iminyaka yamava.I-11AVONEX yenzelwe unyango lwe-relapsing multiple sclerosis (MS), kubandakanywa i-syndromes ezizimeleyo zeklinikhi, abantu abadala abaguquguqukayo abanesifo esincinci kunye nesifo sesibini esisebenzayo.
Ngokweengxelo, izigulane ezifumana i-AVONEX zineempawu zokudakumba, ukucinga ngokuzibulala okanye i-psychosis, kwaye ukuphindaphinda kwamatyala okuzibulala kuye kwanda.Izigulane ezimbalwa zibika umonakalo omkhulu wesibindi, kubandakanywa ukungaphumeleli kwesibindi.Iimeko ezinqabileyo zokwaliwa ziye zaxelwa.Nangona i-beta interferon ayinayo ityhefu yentliziyo ethe ngqo, kuxelwa ukuba akukho zigulana ezinokuthi zaziwayo ziye zaphuhlisa ukungaphumeleli kwentliziyo, i-cardiomyopathy, kunye ne-cardiomyopathy yokusilela kwentliziyo.Amava emva kokuthengisa abonisa ukuba i-peripheral cell counts iyancitshiswa.Ngokweengxelo, izigulane ezisebenzisa i-AVONEX zinokubanjwa, kubandakanywa nalabo abangenayo imbali yokubamba.Izifo ze-Autoimmune zamalungu amaninzi ekujoliswe kuwo ziye zaxelwa.Kunconywa ukwenza i-chemistry yegazi rhoqo, i-hematology, umsebenzi wesibindi kunye novavanyo lomsebenzi we-thyroid rhoqo.
Nceda ucofe apha ngolwazi olubalulekileyo lokhuseleko kunye nolwazi olupheleleyo lokumisela, kuquka izikhokelo zonyango lweziyobisi zeAVONEX eUnited States, okanye undwendwele iwebhusayithi yemveliso kwilizwe/ummandla wakho.
Malunga ne-Biogen e-Biogen, injongo yethu icacile: singoovulindlela kwicandelo le-neuroscience.I-Biogen ifumanisa, iphuhlise kwaye ibonelele ngonyango olutsha kwihlabathi jikelele kubantu abaphethwe zizifo ezinzima ze-neurological kunye nezifo ze-neurodeergenerative kunye nonyango oluhambelanayo.I-Biogen yenye yeenkampani zokuqala zehlabathi ze-biotechnology, yasekwa ngo-1978 nguCharles Weissmann, uHeinz Schaller, uKenneth Murray, kunye nabaphumelele iBhaso leNobel uWalter Gilbert kunye noPhillip Sharp.Namhlanje, i-Biogen inepotifoliyo yamachiza ehamba phambili kunyango lwe-multiple sclerosis, yasungula unyango lokuqala oluvunyiweyo lwe-spinal muscle atrophy, i-biosimilars yorhwebo ye-biologics ephezulu, kwaye igxile ekuqhubeleni phambili i-multiple sclerosis kunye ne-neuroimmunology.Isifo se-Alzheimer kunye ne-dementia, izifo ze-neuromuscular, ukuphazamiseka kwentshukumo, i-ophthalmology, i-immunology, i-neurocognitive disorders, i-neuropathy enzima kunye neentlungu.
Siza kupapasha rhoqo ulwazi olunokubaluleka kubatyali-mali kwiwebhusayithi yethu ethi www.biogen.com.Ukuze ufunde ngakumbi, nceda undwendwele www.biogen.com kwaye usilandele kwimidiya yoluntu Twitter, LinkedIn, Facebook, YouTube.
I-Biogen Safe Harbour Olu shicilelo lweendaba luqulethe iingxelo ezijonge phambili, kubandakanywa neengxelo malunga neenzuzo ezinokuthi zibekho, ukhuseleko kunye nokusebenza kweVUMERITY, TECFIDERA, TYSABRI, PLEGIIDY kunye ne-BIIB091 phantsi kwezibonelelo ezikhuselekileyo zezibuko zoMthetho woHlaziyo lwe-Private Securities Litigation of 1995;Iziphumo zedatha yokwenyani;Uphononongo lwe-EVOLVE-MS-2, uphononongo lwe-ENDORSE Phase 3 kunye ne-BIIB091 iSigaba soku-1 iziphumo zophononongo;ukuchongwa kunye nonyango lwe-MS;isicwangciso sethu sophuhliso lonyango lwe-MS;ingxoxo enokubakho yolawulo, ukungeniswa kunye nokuvunywa kunye naMalungiselelo exesha;amandla oshishino lweBiogen, kuquka iVUMERITY, TECFIDERA, TYSABRI, PLEGRIDY kunye neBIIB091;kunye nemingcipheko kunye nokungaqiniseki okunxulumene nophuhliso lwamachiza kunye norhwebo.Ezi nkcazo zijonge phambili zinokusebenzisa amagama afana nelithi “ithagethi”, “lindela”, “kholwa”, “unako”, “uqikelelo”, “ukulindela”, “uqikelelo”, “injongo”, “injongo”, “inokuba” chonga.“,” “isicwangciso”, “inokwenzeka”, “inokwenzeka”, “intando”, “intando” namanye amagama namagama aneentsingiselo ezifanayo.Ukuphuhliswa kweziyobisi kunye nokuthengiswa kweziyobisi kubandakanya umngcipheko ophezulu, kwaye kuphela inani elincinci lophando kunye nezicwangciso zophuhliso ezikhokelela ekuthengiseni imveliso Iziphumo zezilingo zeklinikhi zakuqala azinakumela iziphumo ezipheleleyo okanye iziphumo zovavanyo lweklinikhi kade okanye enkulu, kwaye ayinakho. baqinisekisa imvume yolawulo.Akufunekanga uthembele ngokugqithisileyo kwezi nkcazo okanye kwidatha yenzululwazi enikiweyo.
Ezi nkcazo zibandakanya imingcipheko kunye nokungaqiniseki, kwaye zingabangela iziphumo zangempela ukuba zahluke kakhulu kwiziphumo ezibonakaliswe kwiingxelo ezinjalo, kubandakanywa kodwa kungaphelelanga kwizehlo ezibi zokhuseleko kunye / okanye iinkxalabo ezingalindelekanga ezinokubangelwa enye idatha okanye uhlalutyo;iindleko ezingalindelekanga okanye ulibaziseko Imingcipheko;Ukukhathazeka okungalindelekanga kunokuvela ngenxa yezinye iinkcukacha, uhlalutyo okanye iziphumo ngexesha lovavanyo lweklinikhi;Asikwazi ukukhusela kunye nokunyanzelisa idatha yethu, amalungelo epropathi enomgangatho ophezulu wokuqonda kunye nobunye ubunini, kunye nokungaqiniseki okunxulumene namabango epropathi enomgangatho ophezulu wokuqonda kunye nemingeni ;Ii-arhente ezilawulayo zinokufuna ulwazi olongezelelweyo okanye uphando olongezelelweyo, okanye zingenakho ukuvuma okanye zinokulibazisa ukuvunywa kwabaviwa bethu bamachiza okanye ukwandiswa kophawu lwemveliso;ukusilela ekufumaneni imvume yolawulo kwezinye iindawo;amabango etyala lemveliso;imingcipheko yentsebenziswano yomntu wesithathu;kunye Ubhubhani we-COVID-19 oqhubekayo uneziphumo ezithe ngqo nezingathanga ngqo kwishishini lethu, iziphumo zokusebenza kunye neemeko zemali.Uninzi kodwa ayizizo zonke ezi zinto zidweliswe ngasentla zinokubangela iziphumo zokwenyani zahluke kwizinto esizilindeleyo kuzo naziphi na iinkcazo ezijonge phambili.Abatyalomali kufuneka baqwalasele le nkcazo yesilumkiso kunye nezinto ezinobungozi esizichongileyo kwingxelo yethu yakutshanje yonyaka okanye yekota kunye nezinye iingxelo esizifake kwiKhomishoni yoKhuseleko kunye noTshintsho.Ezi nkcazo zisekelwe kwiinkolelo zethu zangoku kunye nokulindela kwaye zimele kuphela imeko ukususela ngomhla wolu kukhululwa kweendaba.Nokuba kungenxa yolwazi olutsha, uphuhliso lwexesha elizayo okanye ezinye izizathu, asenzeli uxanduva lokuhlaziya esidlangalaleni naziphi na iinkcazo ezijonge phambili.
I-Mowry EM, i-Beheshtian A, i-Waubant E, njl.I-Neurology.2009;72(20):1760-1765.
ULanz M, uHahn HK, uHildebrandt H. I-Brain atrophy kunye nokuphazamiseka kwengqondo kwi-multiple sclerosis: uphononongo [Izilungiso ezipapashiweyo zipapashwa kwi-J Neurol.2008 Feb;255(2):309-10].Ijenali yeNeurology.2007;254 Ukongeza 2: II43-II48.
Foley J, Xiong K, Hoyt T, njl. Izinga elithambileyo le-serum neurofilament kwizigulane ezine-relapsing-remitting multiple sclerosis yatshintshwa ukusuka kwi-natalizumab kanye kwiiveki ze-4 ukuya kulawulo lwexesha elongezelelweyo.I-AAN 2020;S10.009.
I-Butzkueven, i-Kappos L, i-Spelman T, njl. njlI-ECTRIMS 2019;P1033.
Yamout B, Sahraian MA, Ayoubi NE, njl. Ukusebenza kunye nokhuseleko lwe-natalizumab olulawulwa ngamaxesha awandisiweyo.I-Mult Scler Relat Disord.2018;24: 113-116 .
Zhovtis Ryerson L, Frohman TC, Foley J, njl. Ulawulo lwexesha elongezelelweyo lwe-natalizumab kwi-multiple sclerosis.J Neurol Neurosurgery Psychiatry.2016;87:885-889.
Bomprezzi R, PawateS.I-dosing yexesha elongezelelweyo le-natalizumab: iminyaka eyi-7 yamava kumaziko amabini.Ther Adv Neurol Disord.2014;7: 227-231.
Ukusukela nge-30 kaJuni, 2020, ngokusekwe kwidatha edityanisiweyo yasemva kwentengiso evela kulingo lwezonyango lommiselo kunye nokuvezwa kwi-TECFIDERA.
Ukusukela nge-31 kaJulayi 2020, idatha edityanisiweyo yasemva kokuthengisa esekwe kummiselo kunye nolingo lwezonyango lokuvezwa kwe-TYSABRI.
(Bloomberg) -Ixabiso lesitokhwe se-SAP SE lehle kakhulu njenge-21%, i-drop enkulu yosuku olunye ukususela ngo-1999. Ngaphambili, inkampani yaseWalldorf yanciphisa uqikelelo lwemali engenayo yonyaka kwaye yathi ilindele umjikelezo omtsha wengeniso.Itshixiwe kwisiqingatha sokuqala sika-2021, imfuno ithotyiwe.Kuvavanyo lukaChristian Klein, waba yi-CEO ekhethekileyo ngo-Epreli.Ubhubhani uza kulibazisa ingeniso yelifu ye-SAP, intengiso iyonke kunye nenzuzo yokusebenza ekujoliswe kuyo unyaka okanye emibini, ngakumbi njengoko inkampani yesoftware itshilo kwingxelo ngeCawa.I-SAP yathi ilindele ukukhula okulinganiselwe kunye nemida yenzuzo kwiminyaka emibini ezayo, kwaye iya kuhambisa isicwangciso sayo sobuchule kwi-2023 ukuya ku-2025. U-Klein uthe kwinkomfa yenkomfa ngoMvulo ukuba ulindele ukuba i-SAP ithethe kwingxelo yokuba imbono yangaphambili "icinga ukuba ukuba uqoqosho luza kuphinda luvuleke kwaye ukuvalelwa kwabantu kuya kudamba, okukhokelela kuphuculo oluthe chu kwindawo yemfuno kwikota yesithathu neyesine.”Inkampani kutshanje yaxela kwangaphambili ukuba ngo-2020, ngokusekelwe kumazinga otshintshiselwano olusisigxina, ingeniso ehlengahlengisiweyo iya kufikelela kwi-27.2 yezigidigidi zee-euro ukuya kwi-euro ye-27.8 yezigidigidi (i-32.2 yezigidigidi ukuya kwi-32,9 yeebhiliyoni zeedola zase-US), ephantsi kunokuba ibilindelekile kwaye yanda ukuya kwi-28.5 yezigidigidi zee-euro ukusuka kwisikhokelo sangaphambili. ye 27.8 billion euro.I-Euro.I-SAP ikwaveze ukuba ishishini layo le-Concur alisayi kuphinda lixhamle kwingeniso enxulumene nokuhamba kulo nyaka.Umhlalutyi we-OddoBHF uNicholas David wabhala kwingxelo ukuba kunzima ukufumana iziphumo ezilungileyo kwiziphumo Iindaba.Ulindelo lwemarike kumabhongo aphakathi kwexesha luyoyikeka/luyoyikeka, kodwa amabhongo amatsha asezantsi kunolona lindelo lungenathemba.”I-Qualtrics IPOSAP ithe icandelo layo lesoftware ye-Qualtrics likwinqanaba eliphezulu loluhlu.Yabhengeza ngoJulayi ukuba ithathe isigqibo sokufumana inkampani ngexabiso lerekhodi kwaye yaya esidlangalaleni e-US kwisithuba esingaphantsi kweminyaka emibini.Oku yaba yinguqu ebingalindelekanga kwaye yabonisa utshintsho olucwangcisiweyo phantsi kobunkokeli bukaKlein."Siqhubele phambili kakhulu ekulungiseleleni i-IPO ye-Qualtrics," iGosa eliPhezulu lezeMali uLuka Mucic ngomnxeba ngoMvulo."Intsebenzo eyomeleleyo yekota ye-Qualtrics iya kubeka isiseko sokukhula ngakumbi kulo nyaka uzayo."Imbonakalo entsha yengeniso yelifu kulindeleke ukuba inyuke ukusuka kwi-8.2 yeebhiliyoni zee-euro ukuya kwi-8.2 yeebhiliyoni zee-euro ngo-2020, ngaphantsi koqikelelo lwangaphambili lwe-8.3 yeebhiliyoni zee-euro ukuya kwi-8.7 yeebhiliyoni.Inzuzo yokusebenza ye-Euro kulo nyaka iya kuba phakathi kwe-8.1 yeebhiliyoni zee-Euro kunye ne-8.5 yeebhiliyoni zee-Euro, engaphantsi kune-8.7 ​​yeebhiliyoni ezilindelekileyo.I-SAP iye yandise injongo yayo yaphakathi kwexesha lokudlula i-36 yeebhiliyoni ze-Euro kwingeniso epheleleyo ngo-2025 kwaye iya kufikelela kwi-35 yezigidigidi ze-Euro ngo-2023. , Ngo-2025, ingeniso ye-cloud computing iya kudlula i-22 yezigidigidi zee-euro kunye nenzuzo yokusebenza iya kudlula i-11.5 yeebhiliyoni ze-euro.Inzuzo yokusebenza engeyiyo ye-IFRS kwikota yesithathu yehle nge-12% ngonyaka ukuya kwi-2.07 yeebhiliyoni zee-euro.Xa kuthelekiswa ne-2.15 yeebhiliyoni zee-euro ezilindelwe ngabahlalutyi abahlolisiswe yiBloomberg, ingeniso ngeli xesha yehle nge-4% ukuya kwi-6.54 yeebhiliyoni zee-euro, ngelixa uqikelelo lomhlalutyi oluyi-6.89 yezigidigidi., I-CEO ye-SAP nge-PandemicU.K.I-CMA ithatha indlela yayo kwaye iqala uphando oluchasene ne-antitrust ngokumelene neSinch, icandelo le-SAP i-DealSAP idluliselwe kuJP Morgan Stanley, kwaye uJP Morgan uqhuba i-Qualtrics IPO (uhlaziyo lwesitokhwe, ezinye iimeko).Nceda undwendwele iBloomberg.com ukusindwendwela kwaye ubhalise ngoku.Gcina isikhundla esiphambili njengowona mthombo uthembekileyo weendaba zoshishino.©2020 Bloomberg LP
Umgcini-zincwadi waseSan Francisco uxoxe ngokubaluleka kolawulo lwe-Biden kwiipotfoliyo zotyalo-mali kuyo yonke incoko nabaxumi.
Abasebenzisi abangakhange babeke umyalelo kuyo nayiphi na iqonga le-JD banokufumana amakhuphoni esaphulelo!Ngekhadi lakho leVisa, cofa ukuhlawula e-JD.com okokuqala kwaye wonwabele izaphulelo!
I-Nobel laureate kwezoqoqosho, unjingalwazi weYunivesithi yaseYale uRobert Shiller ukhuthaze abatyali-mali ukuba balumke malunga ne-blockbuster stock market kwikholamu yakutshanje kwi-New York Times.
Inkampani yathi u-Lee Kun-hee, owakha i-Samsung Electronics kwisigebenga sehlabathi kwii-smartphones, i-semiconductors kunye nee-TV, usweleke ngeCawa emva kokuba esibhedlele iminyaka engaphezu kwemithandathu ngenxa yokuhlaselwa yintliziyo ngeCawa.ULee uneminyaka engama-78 ubudala kulo nyaka.Uphuhlise iQela le-Samsung laba yeyona ndibano inkulu eMzantsi Korea kwaye yaba yeyona ndoda isisityebi eMzantsi Korea.UJeong Sun-, i-CEO yenkampani yophando yenkampani i-Chaebul.com, uthe: “Ukukhula okumangalisayo kuka-Lee eKorea nendlela uMzantsi Korea odibana ngayo nomanyano lwehlabathi lufuziselo kangangokuba ukufa kwakhe kuya kukhunjulwa ngabantu abaninzi baseKorea.
Kwiminyaka emine emva kokuwa kweBHS, ngaba ishishini lophicotho-zincwadi eliye lagxekwa ngokungafumani naziphi na iingxaki litshintshile?
Ngokweengxelo ze-CNBC, uJack Ma, umseki we-Alibaba Group Holdings Limited (i-NYSE: i-BABA), uthe ngoMgqibelo ukuba i-Ant Group ye-Ant Group ye-iPOs) e-Shanghai naseHong Kong iya kuba yinkampani enkulu eLuhlu emhlabeni.Kwenzeka ntoni: I-CNBC yathi ixabiso le-IPO lalingoLwesihlanu ebusuku, kodwa uJack Ma akazange achaze inombolo ethile, eya kubhengezwa kwiveki ezayo.Imbali yoluntu-imiselwe ngaphandle kwesiXeko saseNew York.“Utshilo uMa Yun kwiNgqungquthela yaseShanghai Bund.Usozigidi waseTshayina uwubize lo mbandela “njengommangaliso.”Wathi: “Asizange sibe nabuganga bokucinga ngayo kwiminyaka emihlanu okanye emithathu eyadlulayo.“UMa Yun ukwamemelele uhlaziyo lweebhanki kunye nokusekwa kwenkqubo entsha yebhanki yehlabathi ebandakanyayo.Kutheni kubalulekile: Iminikelo kawonkewonke yokuqala yeenkampani ezixhaswa ngu-Alibaba inokuvelisa phantse ibhiliyoni enye kwingeniso, eya kuyenza iSaudi Aramco Umnikelo wokuqala wehlabathi wangaphambili we-US $ 29.4 billion.Isitokhwe sika-Aramco esikhutshwe ngoDisemba ka-2019 soyise u-Alibaba kwaye saphumelela isithsaba se-IPO enkulu.Ngokweengxelo, ingxowa-mali yobutyebi baseSingapore iGIC Private Limited inokudweliswa kolu luhlu lubini.Utyalo-mali ludlula i-US$1 yebhiliyoni.Ngokutsho kweReuters, iTemasek yaseSingapore, umtyali-mali okhoyo we-Ant, naye ubonakalise umdla kwisitokhwe.Isenzo sexabiso: Ixabiso lesitokhwe se-Alibaba livale phantse i-1.2% ngoLwesihlanu ukuya kwi-US $ 309.92.Inyuke nge-0.11% ngexesha leseshoni yokurhweba emva kweeyure.Izivumelwano ezingakumbi ezivela kuBen Singa * Cofa apha ukujonga urhwebo olukhethiweyo lukaBen Singa * I-Quibi iyawa-le ngcamango ayinamandla ngokwaneleyo, ubunkokeli beBenzinga.com (C) bathi ngo-2020: ” Okanye “ixesha” alikho.I-Benzinga ayiboneleli ngeengcebiso zotyalo-mali.onke Amalungelo Agciniwe.
Nikela ngokukhawuleza ukuxhasa i-arhente yababaleki ye-UN, ukwenzela ukuba ababaleki bafumane iikiti eziphuthumayo zokujongana nexesha lemvula kwaye zibasindise kwintlekele!
Kulula ukuthenga amasheya, kodwa kunzima ukuthenga amasheya afanelekileyo ngaphandle kwesicwangciso esivavanywe ixesha.Ke, sesiphi esona sitokhwe esinokusithenga okanye usibeke kuluhlu lokubukela ngoku?
Ikamva lawa kanobom.Imakethi yesitokhwe inokuhamba kunye neenkokheli ezinje ngoMicrosoft kunye noTesla.Njengoko unyulo lusondela kunye namatyala e-coronavirus esanda, le yayiyeyona veki iphakamileyo yengeniso.
UHarry Markopolos (uHarry Markopolos), owayengumchwephesha we-derivatives oye waphendukela kumphandi ozimeleyo wobuqhetseba bezemali, wafumanisa i-65 yezigidigidi ze-Bernie Madoff Ponzi scheme, kodwa yayingahoywa yi-SEC iminyaka elithoba.Njengomgxeki ngokungafihlisiyo wabalawuli baseMelika, uHarry ngoku ujonga icandelo lophicotho-zincwadi kunye neshishini le-inshurensi njengetyala elilandelayo lobuqhophololo eliza kutyhilwa.
I-Annuity entsha ye-Hang Seng exhuzulelwa irhafu ye-intanethi ibonelela nge-10 yeminyaka yengeniso eyongezelelweyo esisigxina kwaye iqinisekisa i-1.73% -2% yokusetha kwakhona ingeniso yangaphakathi.Kuthatha kuphela malunga nemizuzu eyi-10 ukufaka isicelo se-inshurensi kwi-intanethi kwaye wenze ngoko nangoko.
Abantu abathathu abaqhelene nalo mbandela bathi umdibanisi ophezulu we-iPhone, iFoxconn esekwe eTaiwan, useke iqela elisebenzayo lokuxhathisa impembelelo ekhulayo yomenzi we-elektroniki waseTshayina uLuxshare.Inkampani ikholelwa ukuba iLuxshare iyinxalenye yolawulo lwayo.isoyikiso esibi.Omnye wemithombo uthe le projekthi yaqalwa ngumsunguli weFoxconn uGuo Taiming kwaye ekujoliswe kuyo yiLuxshare <002475.SZ> ikomkhulu laseDongguan.Le nkampani yaziwa kancinci kumazwe ngamazwe, kodwa kulindeleke ukuba ibe yinkampani yokuqala ukuhlanganisana kwilizwe lase China.Ikomkhulu le-iPhone-kude kube ngoku, i-turf isalawulwa ngabavelisi baseTaiwan.Umthombo uthe iqela elisebenzayo lasekwa kunyaka ophelileyo kwaye liphanda iteknoloji yeLuxshare, izicwangciso zokwandisa, isicwangciso sokuqasha kunye nokuba inkampani (okwangoku kuphela i-akhawunti ye-5% yengeniso yeFoxconn) ixhaswa yiyiphi na iqumrhu likarhulumente waseTshayina.
Ingeniso ephambili yale veki kunye nengxelo yedatha yezoqoqosho iya kukhutshwa kamva kule veki, kwaye uninzi lwe-FAANG stocks luxelwe emva kokuvalwa ngoLwesine.
Ingxelo yengeniso yekota yesithathu ye-AMD (AMD) icwangciselwe ukukhutshwa emva kokuvalwa ngoLwesibini, ixesha elinomdla kwishishini le-semiconductor.I-Wall Street Journal ibike ukuba i-AMD (AMD) iceba ukwandisa ishishini layo ngokusebenzayo ngokufumana izinto ezinokubakho (XLNX) (XLNX).Kwangaxeshanye, okhuphisana naye omkhulu (INTC) usebenze nzima ukuqhubeka nokuvelisa itekhnoloji yokuvelisa efunekayo ukwenza iisemiconductors ezikumgangatho ophezulu.
Thenga kwiivenkile ezinkulu zefashoni kwi-intanethi kwaye uchithe ngekhadi leVisa ukonwabela ukuya kuthi ga kwi-20% yesaphulelo!Fumana ingqokelela yamva nje kaLuisa Via Roma kunye noTaylor ngoku!
Umhlalutyi weCFRA uGarrett Nelson uthe ngodliwano-ndlebe kunye ne-Yahoo Finance ngoLwesihlanu ukuba uJoe Biden (uJoe Biden) uphumelele ukhetho lukamongameli, uTesla (NASDAQ: TSLA) uya kuba ngowona mkhulu.Okwenzekileyo: UNielsen uthe uTesla uya kuba "yenye yeenkampani ezinkulu" abaphumeleleyo kuba inkampani "yimoto yombane ecocekileyo."Umhlalutyi wachaza ukuba urhulumente waseBiden uza kubonelela ngenkxaso-mali eninzi kwiimoto zombane.Abahlalutyi beCFRA baveze ukuba iBiden icebise "ukwandiswa okukhulu kweekhredithi zerhafu yemoto" kunye "nokwakhiwa okukhulu kwezikhululo zokutshaja iimoto zombane."UNielsen uthe: “Nicinga ukwandisa inani lezikhululo zokutshaja iimoto zombane malunga namaxesha angama-20.Kuya kunceda ngokwenene ukuthandwa kwezithuthi zombane.Kubalulekile: Ngexesha lengxoxo yokugqibela kamongameli eTennessee kwiveki ephelileyo, uBiden wathi urhulumente wakhe uza kutyala imali engama-50,000 yezikhululo zokutshaja iimoto zombane kuhola wendlela.Abaviwa bathi ezi zikhululo zokutshaja ziya kukhokelela eUnited States ukuba ibe "nekamva."Owayesakuba ngusekela-mongameli ukholelwa ukuba umbono wakhe wezithuthi zombane unokujongana nokutshintsha kwemozulu kwaye udale "imisebenzi emitsha ehlawula kakhulu."Inkampani ekhokelwa ngu-Elon Musk ibhengeze ikota yesithathu kwiveki ephelileyo Ingeniso yayiyi-US $ 8.77 billion, ukwanda kwe-39% ngonyaka;Isenzo sexabiso: Izabelo zeTesla zivaliwe malunga ne-1.2% ngoLwesihlanu ukuya kwi-US $ 420.63.Ukuba uJoe Biden uphumelele i-TSLA DateFirmActionUkususela kwamva nje ngo-Okthobha wama-2020 amaxabiso onyulo uMorgan Stanley ugcina ubunzima obulinganayo (ngo-Okthobha 2020) I-Canaccord Genuity igcina urhwebo olubanjwe ngo-Okthobha ka-2020 kwaye ngokungathathi hlangothi igqithisa imarike ebanzi.Bona ezinye iireyithingi zomhlalutyi we-TSLA.Bona uhlalutyi lwamva nje lwentengiselwano* Uhlalutyo lwamva nje lukaBenza lwentengiselwano* uRives Musk uthe iinkonzo zokurenta ngenyanga ziya kufumaneka kulo nyaka uzayo.UJim Kramer uthe uJim Tesla "i-stock crazy" kwi-2020 (C) i-Benzinga.com, "engalunganga" i-Benzinga ayiboneleli ngeengcebiso zotyalo-mali.Onke Amalungelo Agciniwe.
Leliphi iqhinga lotyalo-mali eliye lamelana novavanyo lwexesha?Utyalo-mali lokukhula.Iingcali zaseWall Street zikholelwa ukuba izitokhwe ezinamathemba okukhula ngokugqithisileyo zibonisa ezinye zezona zinto zifunekayo.Lo mandla okukhula ungaphaya koluhlu lwangoku, kwaye la magama aya kufumana imbuyekezo enkulu ngo-2020 nangaphaya.Oko kwathiwa, ukutsho okuncinci, ukufumana izitokhwe eziwela kolu luhlu kunokuba ngumngeni.Abahlalutyi bakholelwa ukuba esinye isicwangciso kukuthatha inyathelo emva, ukujonga umfanekiso omkhulu, kwaye ugxininise kwiinkampani ezinokukhula kwexesha elide ngokusekelwe kwimpumelelo ephawulekayo yonyaka ukuya kutsho.Ukugcina oku engqondweni, sasebenzisa i-database ye-TipRanks ukuchonga izitokhwe ezintathu zokukhula ezilinganiswe kakhulu ngabahlalutyi.Zonke izitokhwe ezintathu zifumene ukukhula okukhulu ngo-2020 kwaye zilungele ukuqhubeka nokunyuka.INkampani yeMidlalo yeSizwe yasePennsylvania (PENN) Okokuqala, singabanini beNkampani yeSizwe yoMdlalo yasePennsylvania, engabanini kwaye eqhuba amaziko emidlalo nemidyarho kunye namashishini esiphelo somdlalo wevidiyo eMelika.Eli gama linyuke nge-146% kunyaka ukuya kuthi ga ngoku, kodwa abanye abahlalutyi baseWall Street bakholelwa ukuba kusekho amafutha amaninzi etankini.I-PENN isandula ukubhengeza iziphumo zayo zekota yesithathu kwangaphambili, ezigqithise ulindelo.Inkampani ilindele ukuba imida yenzuzo yekota inyuke ngamanqaku asisiseko angama-900, kwaye uhlengahlengiso lwe-EBITDAR luya kukhula nge-5% unyaka nonyaka, nokuba ingeniso yehle nge-10% unyaka nonyaka.Umhlalutyi weenkwenkwezi ezintlanu uJoseph Greff uxelele abathengi ukuba "uJP Morgan Chase" uthe: "Ukubuyiselwa kweshishini lomdlalo wengingqi ngoMeyi/Juni kuqhubekile kwaze kwaba yikota yesithathu, kwaye ingeniso ibingcono kunokuba bekulindelwe.Nje ukuba kucinezelwe imfuno Emva kokubuyela kwesiqhelo, kwaye okoko ukusebenza kwe-COVID yangaphambili kuphucukile, iindleko zokusebenza azikhange zinyuke / zinyuke.Ngaphambili besicinga ukuba izinga lokukhula lithotyiwe.”Ukutsho oko, uGreif uvumile ukuba ngokujonga ukusebenza kwexabiso lesitokhwe esibalaseleyo, abanye abahlalutyi baye bashiya ukuthotywa ngasemva”.Nangona kunjalo, usakholelwa ukuba "ixabiso kunye ne-catalyst yekamva".Abahlalutyi bagqabaze: “…Kukho umlo kuluvo lwabatyali-zimali.Sikholelwa ukuba oku kunempilo kwizitokhwe kwaye phantse kuyimfuneko ukuba izitokhwe ziqhubeke nokunyuka;sikholelwa ukuba abatyali-mali bemidlalo yemveli abazange baxhatshazwe ngokupheleleyo.Sikholelwa ukuba abatyali-mali bayathandabuza malunga nokukwazi kwe-PENN ukukhuphisana ne-DraftKings, i-Fanduel, i-Caesars Entertainment, i-MGM / i-GVC, njl njl. ukunyusa ingxowa-mali kunyuse iidola ezingama-950 ezigidi, umngcipheko wolu khuphiswano uncitshisiwe phakathi koluhlu olunentsingiselo.”Okona kubaluleke kakhulu, i-PENN isandula ukuphehlelela i-app ye-Barstool Sports yokubheja ePennsylvania.UGreff ukubize oku kukhutshwa kwangoko “kuyakhuthaza ngokwemiqulu kunye nenkcitho yokuthengisa,” kwaye yangqina “ukubakho kwendlela ekhethekileyo yokuzuza isabelo.”Ukongeza, umfutho weBarstool Sportsbook uyanda.Okubaluleke ngakumbi, uGreff ukholelwa ukuba ukubheja kwezemidlalo yangoku kunye nokusingqongileyo kwe-iGaming kufana nokunyuka kweemarike zengingqi kwiminyaka yoo-1990, xa amazwe anentsilelo yohlahlo lwabiwo-mali ejike kwimithombo emitsha yengeniso, efana nemidlalo yamaphenyane omlambo ukunceda ukugubungela uhlahlo lwabiwo-mali lwabo.intsilelo.Ngokuphathelele oku, umhlalutyi uthe: “Sikholelwa ukuba ilizwe ngalinye liphantse lilindele okufanayo kwi-USB ne-iGaming, kwaye i-PENN iya kuba ngomnye wabaphumeleleyo.Sithanda umdlalo osekelwe kumhlaba / ukubheja kwezemidlalo / ipateni ye-iGaming e-US kwaye sibone indawo yokukhula..”Hayi, ayothusi into yokuba iNgcwabe ihlale namaBhulu.Ukongezelela ekunikezeni umlinganiselo "obunzima", naye wabeka ixabiso elijoliswe kwi-$ 83 kwisitokisi.Ukuba le njongo iphunyeziwe kwiinyanga ezilishumi elinesibini ezizayo, abatyali-mali banokufumana imbuyekezo ye-32%.(Ukubukela irekhodi likaGreif, cofa apha.) Ingaba iWall Street yonke ithini?Ukuthengwa okusithoba, ukubanjwa okuthathu kunye nokuthengiswa okunye kukhutshwe kwiinyanga ezintathu ezidlulileyo.Ngenxa yoko, i-PENN ifumene "ukuthenga okuphakathi" ukulinganiswa kwemvumelwano.Ngokusekelwe kumyinge wexabiso elijoliswe kwi-76.77 yeedola, intengo yesitokhwe inokunyuka nge-22% ngonyaka ozayo.(Jonga uhlalutyo lwe-stock ye-Penn National Gaming kwi-TipRanks.) I-Redfin (RDFN) I-Redfin iqale ngendawo yokukhangela esekelwe kwimephu kwaye yandisa uluhlu lwayo lwemveliso ukwenza imidlalo yentsapho, i-debuts kunye neenkqubo zokubamba ngokukhawuleza kwaye kulula.KwiWall Street, abanye abantu bacinga ukuba igama alikho malunga nokunyuka kwemfuno ye-COVID, kwaye inzuzo yayo ye-113% yonyaka sisiqalo nje.Nangona i-RDFN ilususile uqikelelo oluqinileyo lwekota yesithathu, abatyali-mali baye baphoxeka ngandlel’ ithile sisiphumo.U-Jake Fuller we-BTIG ubonise ukuba ixabiso lesitokhwe linokuhla ngenxa yokuba "okulindelekileyo kuphezulu kwaye ukunyuka okuphakathi kwinqanaba lengeniso malunga ne-2%" kwaye "abatyali-mali abakhawulezayo bavame ukuvuza isigqi esikhokelwa ngumthamo, ngelixa i-RDFN isala emva kolu lindelo."U-Fuller ukholelwa ukuba i-RDFN ayisiyiyo eyona ngqwalasela yabantu abaninzi, nto leyo ebonisa ukuba abatyali-mali basenokuba khange bakubone ukuvezwa kwemivuzo.Nangona kunjalo, ucinga ukuba iWall Street ingaphoswa yinxalenye ephambili yepuzzle.Umhlalutyi weenkwenkwezi ezintlanu ukhankanye: "Into enokuthi ingahoywa apha kukuba i-RDFN inyuse izinga lekhomishini ngaphandle kwempembelelo enkulu kwizinga lokuguqulwa, eliya kuphucula kakhulu imbonakalo yengeniso ye-RDFN."Ukuza kuthi ga ngoku, uya kwenza Ingeniso ye-2021 ilindeleke ukuba inyuke nge-47%.Xa ujongisisa ulwazi oluneenkcukacha lwekota, i-RDFN ifumene imfuno eyomeleleyo kunye nengeniso yeenkonzo zezindlu nomhlaba ikhule ngama-36% unyaka nonyaka.Ukugcwala kwewebhusayithi kunye nomthamo wentengiselwano nako kwanda inyanga nenyanga.Nangona kunjalo, kufuneka kuqatshelwe ukuba ukunyuka kuqhutywe yingeniso yentengiselwano nganye.UFuller uthe: “Oku kubalulekile kuba kubonisa ukuba izinga lekhomishini elilindelekileyo liya kuba negalelo ekugqibeleni.”Ngokwezibalo zethu, ingeniso yeenkonzo zezindlu nezindlu ukusuka kwi-1.68% ye-GTV kwikota yesithathu ka-2019 kunye nekota yesibini ka-2020 inyuke yaya kutsho kwi-1.85% kwikota yesithathu ka-2020. izithuthi eziphezulu kule ndawo.Nangona kunzima ukuvavanya ukuzingisa kwemfuno, ukunyuka kwamaxabiso kunye nemida yengeniso engcono kufuneka igcineke "uFowler uphawule.Ngokuhambelana nethemba lakhe, u-Fuller waxhasa iinkunzi zeenkomo, ephinda umlinganiselo wokuthenga kunye nexabiso le-stock target ye-65 yeedola.Le njongo ivakalisa ukuzithemba kwakhe kumandla e-RDFN okunyusa ngama-45% kulo nyaka uzayo.(Ukujonga irekhodi yengoma kaFuller, cofa apha.) Xa usiya kwezinye iindawo zaseWall Street, izimvo zazahlulahlulwe ngakumbi.Kwiinyanga ezintathu ezidlulileyo, i-6 ithenga, i-5 ibamba kwaye i-1 ithengisiwe.Ngokutsho kweWall Street, i-RDFN yinto ephakathi.I-avareji yexabiso elijoliswe kwi-50 yeedola lithetha i-11% phezulu.(Jonga uhlalutyo lwe-Redfin stock kwi-TipRanks) I-Vertiv Holdings (VRT) Njengenye yezona zinto zihamba phambili kwihlabathi, isoftware kunye nababoneleli benkonzo, i-Vertiv Holdings iye yanceda ukukhuthaza imarike edityanisiweyo yeenkqubo zedijithali, apho inani elikhulu lezinto eziyimfuneko. zihanjiswe, zihlalutywe, zisetyenzwe kwaye zigcinwe.I-Wall Street ithe inyuke nge-71% ukuza kuthi ga ngoku kulo nyaka, kwaye kunokubakho ukuzuza okungakumbi.Nangona ixabiso lesitokhwe likhuphuka ngokukhawuleza, u-Wolfe Umhlalutyi woPhando uNigel Coe usakholelwa ukuba umngcipheko / imeko yomvuzo ilungile.Wachaza: "Sikholelwa ukuba i-Vertiv luhlobo olunqabileyo olunokutsala uluhlu olubanzi lwabatyalo-mali: inkampani yokukhula ephakathi enokubonelela ngokukhula kwenzuzo ekhangayo kwisaphulelo kwaye iphantsi koxanduva lweqela eliphezulu eliphezulu."Xa kuziwa kwi-VRT Endleleni yokukhula, iimarike zayo eziphambili ngamaziko edatha kunye nonxibelelwano lomnxeba.Ezi zithuba ziindawo apho i-Coe ilindele ukufezekisa ukukhula kwi-2020 kunye ne-2021, kunye nokungonakali kwexesha elide eliziswa ngokunyuka okuqhubekayo kwedatha yedatha kunye nokuphuculwa kwe-5G.Ukongeza, ngokuqhutywa ziinzame zokugcina iindleko ezizinzileyo zingaguquguquki ngeendlela ezahlukeneyo zokuphucula ukusebenza kunye nokunciphisa ubunzima bombutho, abaphathi bachaze indlela yokwandisa inzuzo ukuya kuma-500 amanqaku asisiseko."Esi siskripthi esisetyenziswe ngempumelelo ngusihlalo wesigqeba uDavid Cote ngexesha lakhe e-Honeywell, esiqinisekisa ukuba izikripthi ezifanayo zinokuthunyelwa kwi-Vertiv," kusho uCohen.Kuyathakazelisa ukuqaphela ukuba i-VRT irhoxile kwikota yesibini ka-2020, inetyala elipheleleyo elimalunga ne-2.1 yeebhiliyoni zeedola kunye ne-net/EBITDA efikelela kumaxesha angama-4.2.Nasekupheleni kolu luhlu, uCoe ukholelwa ukuba i-balance sheet inokuncipha ngokukhawuleza.Ukuza kuthi ga ngoku, uthatha ukuba ngo-2023 i-net / EBITDA ratio iphindwe kabini, ngoko i-capital eseleyo iya kufikelela kwi-1 yeebhiliyoni zeedola zase-US.“Okwangoku asicingi ukuba iVertiv libali elicacileyo lokusasazwa kwenkunzi, kodwa oku kunokuvela ngaphakathi kwexesha lika-2022/23-ewe, sinokubona imisebenzi yokuthenga ukuze siphucule amandla ayo kwindawo yokuhambisa amandla kunye nomgangatho weDCIM.Olunye ukhetho olunokubakho lubandakanya ukubhangiswa kweziqinisekiso zemali (ezi ngoku zibonakaliswa ngokubala kwethu okuhlanjululweyo kwezabelo) kunye nendlela eya kwabiwa ngayo izabelo, nto leyo eya kwandisa amathuba okuba ngabanini beziko.Kananjalo asinako ukungayihoyi into yokuba izixhobo ezininzi zombane ezinkulu Umda wobuhlakani obusekwe ngabathathi-nxaxheba bentengiso, aba bathathi-nxaxheba ababathathi nxaxheba ababalulekileyo kwiziko ledatha.Yonke into eyenziwe yi-VRT inyanzelise uCoe ukuba aphinde umlinganiselo wayo ogqwesileyo.Ngelixa iinketho zokufowuna, wabeka ixabiso elijoliswe kwi-23 yeedola, oku kuthetha ukuba i-22% inokwenzeka.(Ukujonga irekhodi likaCoe, cofa apha) Ngaba abanye abahlalutyi bayavumelana?bazi.Kwiinyanga ezintathu ezidlulileyo, kuphela i-4 "ukuthenga" okuthe ngqo kuye kwapapashwa.Ke ngoko, umyalezo ucacile: I-VRT yinto eyomeleleyo yokuthenga.Ngenxa yokuba i-avareji yexabiso elijoliswe kuyo yi-$ 20.75, intengo yesitokhwe inokunyuka nge-10% kunyaka ozayo.(Jonga uhlalutyo lwe-stock ye-Vertiv Holdings kwi-TipRanks) Inkcazo: Iimbono ezichazwe kweli nqaku zezo zomhlalutyi oyintloko.Umxholo ubhekiselele kuphela.Ngaphambi kokwenza naluphi na utyalo-mali, kubaluleke kakhulu ukwenza uhlalutyo lwakho.
IMicrosoft, Apple, Alphabet, Facebook, Amazon, AMD, Caterpillar, Comcast, GE, Ford, Pfixer, Visa, UPS, Exxon Mobil, Twitter kunye nezinye iinkampani zichaze iziphumo zabo zekota yesithathu.
Iqonga elitsha lokwabelana lee-SME zaseHong Kong- “Isikhululo seenqwelomoya iHSBC” sikunxulumanisa nolwazi olwahlukileyo lweshishini kunye nemisitho
Kwiveki ephela nge-22 ka-Okthobha, inzala yemali-mboleko yehle yaya kutsho phantsi.Kulindeleke ukuba i-COVID-19 kunye nezopolitiko zaseMelika ziqhubeke nokuba nefuthe kule veki.
I-Trifecta Stocks iya kuchonga i-bearish stocks njalo ngoLwesithathu, kwaye kunokubakho amathuba otyalo-mali anomdla kwixesha elifutshane.Sisebenzisa uhlalutyo lobuchwephesha kwezi tshathi zesitokhwe, kwaye apho kufanelekileyo, ngokusekwe kwi-TheStreet's Quant Ratings 'izenzo zamva nje kunye neereyithingi, siye sasusa amagama amahlanu.Nangona asiyi kuqwalasela uhlalutyo olusisiseko, sinethemba lokuba eli nqaku liza kubonelela abatyali-mali abanomdla kwizitokhwe kunye nesiqalo esihle somsebenzi wesikolo oqhubekayo egameni.
Emva kweminyaka yokusebenza kwirhasi ye-American shale, iChevron ibheja ikamva layo lerhasi yendalo kummandla oguquguqukayo woMbindi Mpuma, kwaye iingcali zamandla kudala zilumkile.Umphathi oyintloko wenkampani uMichael Wirth inyathelo eliqinisekileyo lixhaswa yibheji yokuba uMbindi Mpuma ungena kwixesha loxolelwaniso, nto leyo eya kuyenza ibe lolona khetho lufanelekileyo lokutsalwa kwegesi yendalo, njengoko kulindeleke ukuba ingabizi kakhulu kunexabiso eliphantsi nelicocekileyo.Imfuno iya kudlula ioli.Isicwangciso esitsha kukuba inkampani ikhuthaza ukuthengiselana kwegesi yendalo entsha eYiputa, kwaSirayeli, naseQatar, ngelixa inciphisa inkcitho ekuhlolisweni kwe-shale e-United States.