Idatha entsha evela ocwaningweni oluqhubekayo lweSigaba sesi-3 iphinde ichaze ukusebenza kahle kwe-VUMERITY® (i-Dilosimil fumarate) kanye nokubekezelelwa okuthuthukisiwe kwamathumbu.
Uma kuqhathaniswa ne-Ocrevus® (ocrelizumab), okutholakele kwangempela kuhlole ikhwalithi yezinzuzo zempilo ezihlobene ne-TYSABRI® (natalizumab)
Okunye okutholakele empilweni yangempela kubika izinzuzo ezinhle ze-PLEGRIDY® (peginterferon beta-1a) kanye ne-AVONEX® (interferon beta-1a) ezigulini esezikhulile ezine-multiple sclerosis.
I-Cambridge, Massachusetts, Septhemba 11, 2020 (Izindaba Zomhlaba)-Biogen Inc. (NASDAQ: BIIB) namuhla imemezele idatha entsha eqokomisa i-multiple sclerosis (MS) yayo ehamba phambili embonini Ukusebenza nokuphepha kwenhlanganisela yokwelapha.Le datha izokwethulwa phakathi nomhlangano ohlanganyelwe wesishiyagalombili we-MSVirtual2020, i-American Multiple Sclerosis Treatment and Research Committee kanye ne-European Multiple Sclerosis Treatment and Research Committee (ACTRIMS-ECTRIMS), ozobanjwa kusukela ngoSepthemba 11 kuya ku-13, 2020.
"Isikhulu Esiphezulu Sezokwelapha se-Biogen uMaha Radhakrishnan, MD, uthe: "I-Biogen iyaziqhenya ngoba sizibophezele ekuxazululeni izinselele eziphuthumayo nezesikhathi eside ezibhekene neziguli ze-MS.“Idatha esiyinikezayo ku-ACTRIMS-ECTRIMS igqamisa imiphumela ethuthukisiwe.Iphothifoliyo yethu ebanzi yomkhiqizo we-MS iyaqhubeka nokuhlinzeka iziguli ezine-MS ebuyayo, kungakhathaliseki ukuthi zikuphi enqubweni yokwelashwa, futhi ucwaningo lwethu oluqhubekayo nentuthuko Faka imali ekuthuthukisweni kwabantu abangase basebenzise izidakamizwa.”
Idatha yeSigaba sesi-3 esisha futhi ikhombisa ukusebenza kahle kwe-VUMERITY® (i-Dilosimide fumarate) kanye nokubekezelela i-GI okubikwe ngesiguli.Idatha entsha evela ohlelweni lomtholampilo lwe-VUMERITY Isigaba sesi-3 iphinde ichaze ukwelapha kwakamuva kwe-Biogen nge-fumarate yomlomo Ukusebenza kahle nokuphepha.Uma kuqhathaniswa ne-TECFIDERA® (dimethyl fumarate) (n = 251) kanye nokwesekwa, imiphumela yocwaningo lwamasonto amahlanu lwe-EVOLVE-MS-2 iqinise ukubekezelelana kwe-gastrointestinal (GI) kweziguli ezihloliwe ezihlobene nokwelashwa kwe-VUMERITY Ukubaluleka komtholampilo kokwamukela (n = 253) ithuthukisa umthelela wayo kwikhwalithi yempilo yeziguli ezine-MS ephindaphindiwe.Ababambiqhaza ocwaningweni abathatha i-VUMERITY bathi mancane amathuba okuba babe nezimpawu zesisu eziphazamisa imisebenzi yansuku zonke noma ezihlobene nokuntuleka komsebenzi, futhi kunezidakamizwa ezimbalwa ezisetshenziselwa ukwelapha izimpawu zesisu.
Ukuhlaziywa kokuhlola kocwaningo oluqhubekayo lwe-EVOLVE-MS-1 kuhlole umphumela we-VUMERITY ekushintsheni kwevolumu yobuchopho nezinye izinkomba zomtholampilo kubantu abane-MS ebuyelile (n = 365) abalashwa isikhathi esingafika eminyakeni emibili.Ucwaningo oluhlukene lubonise ukuthi ukuncipha komthamo wobuchopho kungase kuhlobane nokukhubazeka kwengqondo, ukukhubazeka ngokomzimba kanye nokwehla kwezinga lempilo ezigulini ze-MS.1,2, idatha ye-EVOLVE-MS-1 ibonisa:
Izinga lokushintsha kwevolumu yobuchopho yonyaka labahlanganyeli bocwaningo abathole ukwelashwa kwe-VUMERITY iminyaka emibili lalifana nelobantu abanempilo.nge
Cishe i-90% yeziguli ezithola ukwelashwa kwe-VUMERITY azinakho ukuqhubeka kokukhubazeka okuqinisekisiwe, futhi cishe ama-84% awaphindeki phakathi neminyaka emibili.
Idatha yokugcina evela ocwaningweni lweSigaba sesi-3 se-ENDORSE izophinde yethulwe engqungqutheleni, efakazela ngokuqhubekayo ukusebenza kahle okuqhubekayo nokuphepha okuchazwe kahle kwe-TECFIDERA ezigulini ezifika eminyakeni eyi-13.
Idatha yangempela evela ekuhlaziyweni okuhlukile kwenani labantu be-MS ibonisa ukuthi nge-MS PATHS (Partner Advance Technology and Health Solutions), TYSABRI® (natalizumab), PLEGRIDY® (pegylated interferon beta-1a) kanye nemiphumela ye-AVONEX® (interferon beta-1a) sebethuthukile., i-Biogen ibambisana nezikhungo ezihamba phambili ze-MS eYurophu nase-United States ukuze kukhiqizwe idatha esezingeni eliphezulu evela kubantu abahlukahlukene be-MS emhlabeni wangempela.Kuze kube manje, zingaphezu kuka-17,000 iziguli ezibambe iqhaza ku-MS PATHS.Idatha etholwe ekwelashweni endaweni yangempela isekela imiphumela ethuthukisiwe ehlotshaniswa ne-TYSABRI, PLEGIDYY kanye ne-AVONEX.Imiphumela yokuhlaziywa okuhlukile kudatha ye-MS PATHS ibonisa:
Esiqhathanisweni sokuqala sohlelo lwe-MS PATHS olujwayelekile lwe-magnetic resonance imaging (MRI), izinguquko phakathi nenkathi yokudosa yesikhawu enwetshiwe (EID; n = 85) ye-natalizumab iqhathaniswe ne-MRI yobuchopho evunyelwe (okusho ukulandela iminyaka engu-0.8).Kanye njalo emavikini amane (Q4W; n = 569).Ukuhlaziywa akubikile umehluko ophawulekayo kusifo esisha se-T2, izifo eziguquguqukayo ze-T2 kanye nezinga le-brain atrophy.Umehluko kuzikena ze-MRI kanye nezinqubo zokuthola izinto ekusebenzeni komtholampilo kwenza ukuqhathanisa imiphumela ye-MRI yobuchopho kube inselele.Ucwaningo oluningi lomhlaba wangempela lubonise ukuthi ukusebenza kahle kwe-natalizumab EID kuyafana nedosi egunyaziwe ye-Q4W.I-3-7Biogen iyaqhubeka nokuhlola ukusebenza kahle, ukuphepha kanye nokubekezelelana kwe-natalizumab EID ngokusebenzisa isivivinyo esilindelwe se-NOVA (NCT03689972), futhi muva nje ithumele isicelo sokuphatha okungaphansi kwesikhumba kusiphathimandla esilawulayo.Uma kuvunyiwe, Izohlinzeka ngezinketho ezengeziwe zokuphatha kwe-TYSABRI.
Ngokusho kokuhlolwa kwe-Neuro-QoL (Ikhwalithi Yokuphila Ezifweni Zesistimu Yezinzwa), ukwelashwa kwe-TYSABRI kunokuthuthuka okukhulu kukhwalithi ethile yokuphila kune-Ocrevus® (ocrelizumab).Ekuhlaziyweni kweqembu elingaphansi kweziguli ezifanisiwe ezilashwe nge-TYSABRI noma i-Ocrevus, kubonwe ukuthi izizinda eziyi-9 kwezingu-12 ze-Neuro-QoL ezigulini ezilashwe nge-TYSABRI zithuthuke kakhulu (n = 144).4 kwezingu-12 izizinda zibe ngcono kakhulu (n = 502)).Sekukonke, izinga lokuthuthukisa lonyaka le-TYSABRI liphezulu kunele-Ocrevus, futhi umehluko omkhulu ubonwa ezicini ezintathu: ithonya elihle kanye nokuphila kahle, ukwaneliseka ngezindima nemisebenzi yomphakathi, nokuphazamiseka kokulala.
Uma kuqhathaniswa neziguli ze-MS ezingaphansi kweminyaka engu-60 ubudala (n = 729), imiphumela yomtholampilo yeziguli ze-MS ezingaphezu kweminyaka engu-60 ubudala (n = 286) ibonise ukuthi kuzo zombili amaqembu obudala, kokubili i-PLEGRIDY kanye ne-AVONEX inganikeza izinzuzo ezisebenzayo Izinzuzo zokwelapha.Idatha ibonisa ukuthi ukuhlolwa kwesivinini sokucubungula (i-PST) kanye nokuhlolwa kokuzwela kokuqhathanisa (CST) kwamaqembu amabili obudala kuye kwathuthuka esikhathini esingaphezu konyaka owodwa.Ngaphezu kwalokho, iningi labahlanganyeli kuwo womabili amaqembu obudala abazange baphinde babuyele emuva phakathi neminyaka emibili.
Idatha evela ocwaningweni lweSigaba 1 se-BIIB091 isekela ukwelashwa okuqhubekayo kwe-MSBiogen, futhi idatha evela ocwaningweni lweSigaba 1 se-BIIB091 nayo inikeziwe.I-BIIB091 iyisivimbeli se-molecule ye-molecule ekhethiwe, ehlehliswayo (engahlangani) yomsebenzi womlomo we-Ejenti ye-Bruton's tyrosine kinase (BTK).Idatha yahlola ukuphepha, ukubekezelelana, i-pharmacokinetics kanye ne-pharmacodynamics yemithamo yomlomo eyodwa kanye nenqwaba ekhulayo ezifundweni zabantu abadala abanempilo.Ukuvinjelwa kwe-BTK okukhethiwe kungaba yinzuzo ekwelapheni kwe-MS ngokuvimbela ukusebenza kwamaseli e-B namaseli e-myeloid ngaphandle kokuncipha kwamaseli omzimba.
Ukwethulwa kwedatha ku-ACTRIMS-ECTRIMS: Qaphela: Zonke izethulo zephosta ze-MSVirtual2020 zizotholakala ku-inthanethi ngo-8 AM Isikhathi SaseMpumalanga ngoLwesihlanu, Septhemba 11, 2020.
Uma kuqhathaniswa ne-dimethyl fumarate ku-EVOLVE-MS-2, ukubekezelelana kwe-GI okuthuthukisiwe kwe-Diroximel fumarate kuhlobene kakhulu nokubaluleka komtholampilo kwekhwalithi yokuphila (Iphosta 0214)
Umphumela we-Diroximel fumarate ekushintsheni kwevolumu yobuchopho nokuqhubekela phambili kokukhubazeka kubantu abadala abane-EVOLVE-MS-1 relapsing-remitting multiple sclerosis (Iphosta P0205)
Ukuphepha nokusebenza ngempumelelo kweziguli ezilashwa nge-dimethyl fumarate nokulandelwa iminyaka engu-13: imiphumela yokugcina ye-ENDORSE (inkundla FC02.05-Sunday, September 13th 1:48-2:00 US Eastern Time)
Imiphumela ye-radiology yeziguli ezinemithamo yesikhawu enwetshiwe ye-Natalizumab ayihlukile kumithamo yesikhawu evamile ku-MS PATHS (Poster P0360)
Umthelela we-Natalizumab Kukhwalithi Yempilo Eqeqebeni Langempela Leziguli Ze-Multiple Sclerosis: Imiphumela Ye-MS Pathway (Iphosta P1036)
Izici kanye nemiphumela yomtholampilo yeziguli ezikhulile ze-MS ezine-Peginterferon Beta-1a noma i-interferon ye-intramuscular Beta-1a ekwelapheni kwe-MS pathway (Poster P0843)
Ucwaningo lwesigaba 1 se-BIIB091 (i-Bruton's tyrosine kinase (BTK) inhibitor) kubahlanganyeli abadala abanempilo: imiphumela yokuqala (iphosta P0186)
Mayelana ne-VUMERITY® (Dilosemate Fumarate) I-VUMERITY iyi-fumarate yomlomo enesakhiwo samakhemikhali esihluke ngokuphelele kwa-TECFIDERA® (Dimethyl Fumarate), egunyazwe e-United States ukuze zelashwe i-multiple sclerosis kubantu abadala Izinhlobo zesifo eziphindaphindayo zihlanganisa ama-syndromes ahlukanisiwe ngokomtholampilo, izifo eziqhubekayo eziphindaphindayo kanye nezifo eziqhubekayo eziqhubekayo zesibili.Ngemva kokungena emzimbeni, i-VUMERITY iguqulwa ngokushesha ibe yi-monomethyl fumarate, i-metabolite efanayo esebenzayo ye-dimethyl fumarate.
I-VUMERITY ivinjelwa ezigulini ezingazwani ne-Diroximel fumarate, i-dimethyl fumarate nanoma yiziphi izinto ezisizayo ze-VUMERITY;kanye neziguli ezithatha i-dimethyl fumarate.Imiphumela emibi kakhulu ye-VUMERITY isekelwe kudatha ye-dimethyl fumarate (i-metabolite efanayo esebenzayo njenge-VUMERITY), okuhlanganisa ukungezwani komzimba kanye ne-angioedema, i-leukoencephalopathy ye-multifocal eqhubekayo, okuwubuchopho obungosomathuba obungavamile Ukutheleleka ngegciwane kuhlobene nokufa noma ukugula okunzima.Ukukhubazeka, ukuncipha kwenani le-lymphocyte elimaphakathi ngonyaka wokuqala wokwelashwa, ama-shingles nezinye izifo ezimbi kakhulu, ukulimala kwesibindi nokushaywa.Izehlakalo ezimbi ezivame kakhulu ezitholwe kusetshenziswa idatha evela ku-dimethyl fumarate (ene-metabolite efanayo esebenzayo njenge-VUMERITY) kwaba ukukhukhumala, ubuhlungu besisu, isifo sohudo, nesicanucanu.
Sicela uchofoze lapha ukuze uthole ulwazi olubalulekile lokuphepha kanye nolwazi oluphelele lwencwadi kadokotela, okuhlanganisa nemininingwane yesiguli ye-VUMERITY e-United States.
Mayelana ne-TECFIDERA® (dimethyl fumarate) I-TECFIDERA iyindlela yokwelapha yokuphinda i-multiple sclerosis (MS) kubantu abadala.Uwumuthi onqunyelwe kakhulu wokubuyela ku-MS emhlabeni.Kuye kwafakazelwa ukunciphisa izinga lokuphindaphinda kwe-MS futhi yehlise ijubane.Ithuthukela ekukhubazekeni futhi ithinte isibalo sezilonda zobuchopho be-MS, futhi ifakazela ukuthi ukuphepha kwesici seziguli ezine-MS ebuyele emuva kuhle.I-TECFIDERA igunyazwe emazweni/ezifundeni ezingu-69 futhi yelashwe iziguli ezingu-475,000, okusho ukuthi iminyaka engaphezu kuka-950,000 yeziguli ezisebenzisa futhi zichaza i-TECFIDERA.Kulezi, iziguli eziyi-6,335 (iminyaka eyi-14,241 yesiguli) zivela ezivivinyweni zomtholampilo8.
I-TECFIDERA ivinjelwa ezigulini ezingazwani ne-dimethyl fumarate noma ezinye zezinto ezisizayo ze-TECFIDERA.Imiphumela emibi kakhulu ihlanganisa ukungezwani komzimba kanye ne-angioedema, kanye nezimo ze-progressive multifocal leukoencephalopathy (izifo zobuchopho ezingosomathuba ezingandile ezihlobene nokufa noma ukukhubazeka okukhulu) ziye zabonwa ezigulini ze-TECFIDERA ezine-lymphopenia yesikhathi eside, nakuba indima ye-lymphopenia ingaqinisekile kulezi zimo. .Eminye imiphumela emibi kakhulu ihlanganisa ukwehla kwesilinganiso se-lymphocyte phakathi nonyaka wokuqala wokwelashwa, ama-shingles nezinye izifo ezimbi kakhulu, ukulimala kwesibindi kanye nokushaywa.Ezivivinyweni zomtholampilo, izehlakalo ezimbi ezivame kakhulu ezihambisana ne-TECFIDERA kwakuwukushaywa umoya, ubuhlungu besisu, isifo sohudo kanye nesicanucanu.
Sicela uchofoze lapha ukuze uthole ulwazi olubalulekile lokuphepha kanye nolwazi oluphelele lwencwadi kadokotela, okuhlanganisa nemininingwane yesiguli ye-TECFIDERA yase-United States, noma uvakashele iwebhusayithi yomkhiqizo ezweni/isifunda sakho.
Mayelana ne-TYSABRI® (natalizumab) I-TYSABRI iwukwelashwa okusebenzayo kwe-relapsing multiple sclerosis (RMS), engasetshenziselwa ukuphinda kwe-MS kubantu abadala.Izivivinyo zemitholampilo ziye zafakazela ukuthi lokhu kwelashwa kungabambezela ukuqhubeka kokukhubazeka ngokomzimba futhi kunciphise Ukwakheka kwezilonda ezintsha zobuchopho futhi kunciphise ukuphindeka.I-TYSABRI ivunyiwe emazweni/ezifundeni ezingama-80.Ngokuya ngezivivinyo zemitholampilo kanye nedatha kadokotela, i-TYSABRI ithole ukwelashwa kwe-TYSABRI kubantu abangaphezu kuka-213,000 emhlabeni jikelele, kanye nesipiliyoni seminyaka yesiguli engaphezu kuka-835,000.9
I-TYSABRI inyusa ubungozi be-progressive multifocal leukoencephalopathy (PML), ukutheleleka ngegciwane okungosomathuba okungajwayelekile kobuchopho okuhlotshaniswe nokufa noma ukukhubazeka okunzima.Isici esiyingozi esikhulisa ubungozi be-PML ubukhona bamasosha omzimba alwa ne-JC, ukusetshenziswa kwama-immunosuppressive agents kanye ne-TYSABRI ukuze uthole ukwelashwa isikhathi eside.Iziguli ezinalezi zici ezintathu zobungozi zinengozi enkulu kakhulu ye-PML.Lapho uqala futhi uqhubeka nokwelashwa nge-TYSABRI, odokotela kufanele bacabangele ukuthi izinzuzo ezilindelekile ze-TYSABRI zanele yini ukuqeda le ngozi.
I-TYSABRI futhi yandisa ingozi yokuthuthukisa i-encephalitis kanye ne-meningitis ebangelwa i-herpes simplex kanye namagciwane e-varicella-zoster.Ngokwemibiko, iziguli ze-MS ezithola i-TYSABRI zinezimo ezinzima, ezisongela ukuphila futhi ezibulalayo ngemva kwemakethe.Esimweni sangemva kokumaketha, kukhona nokulimala kwesibindi okubalulekile emtholampilo, okuhlanganisa ukuhluleka kwesibindi okunamandla okudinga ukufakelwa kabusha.Ezinye izehlakalo ezimbi kakhulu ezenzeke ezigulini ezilashwa nge-TYSABRI zihlanganisa ukungezwani komzimba (okufana nokungezwani komzimba) kanye nezifo, okuhlanganisa izifo ezingosomathuba nezinye izifo ezingavamile.
Sicela uchofoze lapha ukuze uthole ulwazi olubalulekile lokuphepha, okuhlanganisa izixwayiso ezisebhokisini, kanye nolwazi oluphelele lwencwadi kadokotela, kuhlanganise negayidi yemithi yase-US TYSABRI, noma vakashela iwebhusayithi yomkhiqizo ezweni/isifunda sakho.
Mayelana ne-PLEGRIDY® (i-pegylated interferon β-1a) I-PLEGRIDY iyi-interferon engaphansi kwe-pegylated, kanye ngemva kwamasonto amabili, yohlobo oluphindaphindiwe lwe-multiple sclerosis (MS) kubantu abadala, okuwuhlobo oluvame kakhulu lwe-MS.Ifomu elijwayelekile.I-PLEGRIDY okwamanje ivunyelwe emazweni/ezifundeni ezingaphezu kuka-60, okuhlanganisa i-United States, Canada, Australia ne-Switzerland, kanye ne-European Union yonke.Ngokusho kwedatha kadokotela, cishe abantu abangu-57,000 emhlabeni wonke bathole ukwelashwa kwe-PLEGRIDY, nesipiliyoni seminyaka engaphezu kwe-107,000 yesiguli.I-10Biogen iyaqhubeka nokusebenza ukuze inikeze i-PLEGRIDY kwamanye amazwe/izifunda emhlabeni jikelele.
Ukusebenza nokuphepha kwe-PLEGRIDY kusekelwa olunye lwezifundo ezibaluleke kakhulu, olwasebenzisa ukwelashwa kwe-interferon ezigulini ezine-MS ebuyisela kabusha.Ezifundweni zomtholampilo, kufakazelwe ukuthi i-PLEGRIDY inganciphisa kakhulu izinga lokuphindaphinda kwe-MS, ibambezele ukuqhubeka kokukhubazeka futhi inciphise inani lokulimala kobuchopho ku-MS.Ngasikhathi sinye, kufakazelwe ukuthi ukuphepha kweziguli ezine-MS ebuyele emuva kuhle.Imiphumela emibi ebikiwe ihlanganisa izinkinga zesibindi, kuhlanganise nokuhluleka kwesibindi kanye nokwanda kwama-enzyme esibindi;ukucindezeleka noma imicabango yokuzibulala;ukusabela okukhulu kwe-allergic;izinkinga zenhliziyo, kuhlanganise nokuhluleka kwenhliziyo;izifo ze-autoimmune;ukwehla kwamangqamuzana amhlophe egazi noma izibalo zeplatelet;kanye nokuquleka.Ezivivinyweni zomtholampilo, izehlakalo ezimbi ezivame kakhulu ezihlobene ne-PLEGRIDY kwaba ukusabela kwendawo yomjovo kanye nezimpawu ezinjengomkhuhlane.Uhlu lwezehlakalo ezimbi lungatholakala kulebula yomkhiqizo ephelele ye-PLEGRIDY yezwe ngalinye elaziwayo.
Sicela uchofoze lapha ukuze uthole ulwazi olubalulekile lokuphepha kanye nolwazi oluphelele lwemiyalelo, okuhlanganisa imihlahlandlela ye-US PLEGRIDY yokwelashwa kwezidakamizwa, noma uvakashele iwebhusayithi yomkhiqizo ezweni/isifunda sakho.
Mayelana ne-AVONEX® (Interferon beta-1a) I-AVONEX yakhelwe ukuphinda i-MS, futhi ivunyelwe emazweni angaphezu kuka-90.Ngokusho kwedatha kadokotela, abantu abangaphezu kuka-580,000 emhlabeni wonke bathole ukwelashwa kwe-AVONEX, nesipiliyoni seminyaka engaphezu kwezigidi ezingu-2.6 sesiguli.I-11AVONEX iklanyelwe ukwelashwa kwe-relapsing multiple sclerosis (MS), kuhlanganise ne-syndromes ehlukanisiwe emtholampilo, abantu abadala ababuyela emuva abanesifo esincane kanye nesifo sesibili esiqhubekayo esisebenzayo.
Ngokwemibiko, iziguli ezithola i-AVONEX zinezimpawu zokucindezeleka, ukucabanga ukuzibulala noma i-psychosis, futhi imvamisa yamacala okuzibulala anyukile.Zimbalwa iziguli ezibika ukulimala okukhulu kwesibindi, okuhlanganisa ukuhluleka kwesibindi.Izimo ezingavamile zokungezwani komzimba ziye zabikwa.Nakuba i-beta interferon ingenabo ubuthi benhliziyo obuqondile, kubikwa ukuthi azikho iziguli ezinokuthambekela okwaziwayo eziye zahlakulela ukuhluleka kwenhliziyo eqinile, i-cardiomyopathy, kanye ne-cardiomyopathy yokuhluleka kwenhliziyo.Okuhlangenwe nakho kwangemva kokumaketha kubonisa ukuthi ukubalwa kwamangqamuzana egazi aseduze kwehlile.Ngokwemibiko, iziguli ezisebenzisa i-AVONEX ziba nokuquleka, okuhlanganisa nalezo ezingenawo umlando wokuquleka.Izifo ze-autoimmune zezitho eziningi ezihlosiwe ziye zabikwa.Kunconywa ukwenza amakhemikhali egazi avamile, i-hematology, ukusebenza kwesibindi kanye nokuhlolwa komsebenzi we-thyroid njalo.
Sicela uchofoze lapha ukuze uthole ulwazi olubalulekile lokuphepha kanye nolwazi oluphelele lwemiyalelo, okuhlanganisa imihlahlandlela yokwelashwa kwezidakamizwa ye-AVONEX yase-United States, noma vakashela iwebhusayithi yomkhiqizo ezweni/isifunda sakho.
Mayelana ne-Biogen At Biogen, umgomo wethu ucacile: singamaphayona emkhakheni wesayensi yezinzwa.I-Biogen ithola, ithuthukise futhi inikeze izindlela zokwelapha ezintsha emhlabeni wonke kubantu abahlushwa izifo ezinzima zemizwa nezifo ze-neurodegenerative kanye nokwelashwa okuhlobene.I-Biogen ingenye yezinkampani zokuqala emhlabeni jikelele ze-biotechnology, eyasungulwa ngo-1978 nguCharles Weissmann, uHeinz Schaller, uKenneth Murray, kanye nabawine uMklomelo kaNobel uWalter Gilbert noPhillip Sharp.Namuhla, i-Biogen inephothifoliyo yezidakamizwa ehamba phambili yokwelapha i-multiple sclerosis, yethula ukwelashwa kokuqala kwe-spinal muscle atrophy, okudayiswayo kwe-biosimilars ye-Advanced biologics, futhi igxile ekuthuthukiseni i-multiple sclerosis kanye ne-neuroimmunology.Isifo se-Alzheimer kanye nokuwohloka komqondo, izifo ze-neuromuscular, ukuphazamiseka kokunyakaza, i-ophthalmology, i-immunology, ukuphazamiseka kwe-neurocognitive, i-neuropathy ebuhlungu kanye nobuhlungu.
Sizoshicilela njalo ulwazi olungase lubaluleke kubatshalizimali kuwebhusayithi yethu ethi www.biogen.com.Ukuze ufunde kabanzi, sicela uvakashele ku-www.biogen.com futhi usilandele ezinkundleni zokuxhumana i-Twitter, i-LinkedIn, i-Facebook, i-YouTube.
I-Biogen Safe Harbour Lokhu kukhishwa kwabezindaba kuqukethe izitatimende ezibheke phambili, okuhlanganisa izitatimende eziphathelene nezinzuzo ezingaba khona, ukuphepha nokusebenza ngempumelelo kwe-VUMERITY, TECFIDERA, TYSABRI, PLEGIIDY kanye ne-BIIB091 ngaphansi kwezinhlinzeko zechweba eziphephile zoMthetho Wokuguqulwa Kwamacala Ezibambiso Eziyimfihlo ka-1995;Imiphumela yedatha ethile yangempela;Ucwaningo lwe-EVOLVE-MS-2, ucwaningo lwe-ENDORSE Isigaba sesi-3 kanye nemiphumela yocwaningo lwe-BIIB091 Isigaba 1;ukuhlonza nokwelashwa kwe-MS;uhlelo lwethu lokuthuthukisa ukwelashwa kwe-MS;Izingxoxo ezingase zibe khona zokulawula, ukuhanjiswa kanye nokugunyazwa kanye namalungiselelo esikhathi;amandla ebhizinisi lezentengiso le-Biogen, okuhlanganisa i-VUMERITY, TECFIDERA, TYSABRI, PLEGRIDY kanye ne-BIIB091;kanye nezingozi nokungaqiniseki okuhlobene nokuthuthukiswa kwezidakamizwa nokudayiswa.Lezi zitatimende ezibheke phambili zingasebenzisa amagama anjengokuthi “okuhlosiwe”, “lindela”, “kholwa”, “ungakwazi”, “ukulinganisa”, “lindela”, “isibikezelo”, “okuhlosiwe”, “hlosa”, “kungenzeka” Ukuze khomba.“,” “pulani”, “kungenzeka”, “okungenzeka”, “intando”, “intando” namanye amagama namagama anezincazelo ezifanayo.Ukuthuthukiswa kwezidakamizwa nokudayiswa kuhilela izinga eliphezulu lobungozi, futhi inani elincane kuphela lezinhlelo zocwaningo nentuthuko eziholela ekuthengisweni kwemikhiqizo Imiphumela yokuhlolwa kwangaphambi kwesikhathi yokuhlolwa kwemitholampilo ingase ingameleli imiphumela ephelele noma imiphumela yokuhlolwa kwakamuva noma okukhulu kwemitholampilo, futhi ayikwazi. baqinisekisa ukugunyazwa kokulawula.Akufanele uthembele ngokweqile kulezi zitatimende noma kudatha yesayensi enikeziwe.
Lezi zitatimende zibandakanya ubungozi nokungaqiniseki, futhi zingabangela imiphumela yangempela ukuthi ihluke kakhulu emiphumeleni evezwe ezitatimendeni ezinjalo, okuhlanganisa kodwa kungagcini nje ngokwenzeka kwezehlakalo ezimbi zokuphepha kanye/noma ukukhathazeka okungalindelekile okungase kubangelwe enye idatha noma ukuhlaziywa;izindleko ezingalindelekile noma ukubambezeleka Izingozi;Ukukhathazeka okungalindelekile kungase kuphakame ngenxa yolunye ulwazi, ukuhlaziywa noma imiphumela phakathi nokuhlolwa kwemitholampilo;Asikwazi ukuvikela nokuphoqelela idatha yethu, amalungelo empahla yengqondo nobunye ubunikazi, nokungaqiniseki okuhlobene nezimangalo zempahla esunguliwe nezinselele ;Ama-ejensi alawulayo angase adinge ulwazi olwengeziwe noma ucwaningo olwengeziwe, noma angase angakwazi ukugunyaza noma angase abambezele ukugunyazwa kwamakhandidethi ethu ezidakamizwa noma ukunwetshwa kokulebula komkhiqizo;ukwehluleka ukuthola imvume yokulawula kwezinye izindawo;izimangalo zesikweletu somkhiqizo;izingozi zokubambisana ezivela eceleni;kanye Nobhubhane oluqhubekayo lwe-COVID-19 lunemiphumela eqondile nengaqondile ebhizinisini lethu, imiphumela yokusebenza nezimo zezezimali.Izinto eziningi kodwa akuzona zonke ezibalwe ngenhla zingabangela imiphumela yangempela ukuthi ihluke kulokho esikulindele kunoma yiziphi izitatimende ezibheke phambili.Abatshalizimali kufanele bacabangele lesi sitatimende esiyisixwayiso kanye nezici zobungozi esizihlonze embikweni wethu wakamuva wakamuva wonyaka noma wamakota kanye neminye imibiko esiyithumela ku-Securities and Exchange Commission.Lezi zitatimende zisekelwe ezinkolelweni zethu zamanje nesikulindele futhi zimele kuphela isimo kusukela ngedethi yalokhu kukhishwa kwezindaba.Kungakhathaliseki ukuthi kungenxa yolwazi olusha, ukuthuthukiswa kwesikhathi esizayo noma ezinye izizathu, asenzi isibopho sokubuyekeza esidlangalaleni noma yiziphi izitatimende ezibheke phambili.
I-Mowry EM, i-Beheshtian A, i-Waubant E, njll. Izinga lempilo ku-multiple sclerosis lihlobene nomthwalo wezifo kanye nezinkomba zokulinganisa umthamo wobuchopho.I-Neurology.2009;72(20):1760-1765.
U-Lanz M, u-Hahn HK, u-Hildebrandt H. I-Brain atrophy kanye nokukhubazeka kwengqondo ku-multiple sclerosis: isibuyekezo [Izilungiso ezishicilelwe zishicilelwa ku-J Neurol.2008 Feb;255(2):309-10].Ijenali ye-Neurology.2007;254 Isengezo 2: II43-II48.
I-Foley J, Xiong K, Hoyt T, njll. Izinga elimaphakathi le-serum neurofilament ezigulini ezine-relapsing-remitting multiple sclerosis lashintshwa lisuka ku-natalizumab kanye njalo emavikini angu-4 ukuya ekulawuleni isikhawu esinwetshiwe.I-AAN 2020;S10.009.
I-Butzkueven, i-Kappos L, i-Spelman T, njll. Iziguli ezishintshele ku-natalizumab ukuze zithole umthamo wesikhathi esinwetshiwe noma ukugcinwa kwesilinganiso sesikhawu esijwayelekile zazingenawo umehluko omkhulu emiphumeleni yokuphinda: ukuhlaziya ukusebenza kahle okuqhathaniswayo kwesikolo sokuthambekela kweziguli kuhlelo lokubheka lwe-TYSABRI.I-ECTRIMS 2019;P1033.
I-Yamout B, Sahraian MA, Ayoubi NE, njll. Ukusebenza nokuphepha kwe-natalizumab kulawulwa ngezikhathi ezinwetshiwe.I-Mult Scler Relat Disord.2018;24:113-116.
U-Zhovtis Ryerson L, Frohman TC, Foley J, njll. Ukulawulwa kwesikhawu okunwetshiwe kwe-natalizumab ku-multiple sclerosis.J Neurol Neurosurgery Psychiatry.2016;87:885-889.
Bomprezzi R, PawateS.Umthamo owengeziwe wesikhawu we-natalizumab: iminyaka engu-7 yesipiliyoni ezikhungweni ezimbili.I-Adv Neurol Disord.2014;7: 227-231.
Kusukela ngomhla ka-30 Juni 2020, ngokusekelwe kudatha ehlanganisiwe yangemva kokuthengisa evela ezivivinyweni zomtholampilo zencwadi kadokotela nokuchayeka ku-TECFIDERA.
Kusukela ngomhla ka-31 Julayi 2020, idatha ehlanganisiwe yangemuva kokuthengisa esuselwe kumyalelo kadokotela nezivivinyo zomtholampilo zokuchayeka kwe-TYSABRI.
(Bloomberg)-Inani lesitoko se-SAP SE lehle lafinyelela ku-21%, ukwehla okukhulu kosuku olulodwa kusukela ngo-1999. Ngaphambilini, inkampani yase-Walldorf yehlisa isibikezelo sayo semali engenayo yonyaka wonke futhi yathi ilindele umjikelezo omusha wemali engenayo.Ikhiyiwe engxenyeni yokuqala ka-2021, isidingo sehlisiwe.Ekuhlolweni kukaChristian Klein, waba yi-CEO ekhethekile ngo-Ephreli.Lolu bhubhane luzobambezela imali engenayo ye-SAP yamafu, ukuthengiswa okuphelele kanye nezinhloso zenzuzo yokusebenza unyaka noma emibili, ikakhulukazi njengoba inkampani yesoftware isho esitatimendeni ngeSonto.I-SAP ithe ilindele ukukhula okulinganiselwe kanye nemikhawulo yenzuzo eminyakeni emibili ezayo, futhi izohambisa uhlelo lwayo lwamasu luka-2023 kuya ku-2025. UKlein uthe ocingweni lwengqungquthela ngoMsombuluko ulindele ukuthi i-SAP isho esitatimendeni ukuthi umbono odlule "ucabanga ukuthi ukuthi umnotho uzophinde uvuleke futhi ukuvalelwa kwabantu kuzodamba, okuholela ekuthuthukisweni kancane kancane kwesimo esidingekayo engxenyeni yesithathu neyesine.”Le nkampani isanda kubikezela ukuthi ngo-2020, ngokusekelwe emazingeni okushintshanisa ashintshiwe, imali engenayo elungisiwe izofinyelela ku-27.2 billion euros kuya ku-27.8 billion euros (32.2 billion kuya ku-32.9 billion US dollars), ephansi kunalokho obekulindelwe futhi ikhuphuke yaba ngama-euro ayizigidi eziyizinkulungwane ezingama-28.5 kusukela esiqondisweni sangaphambilini. ngama-euro ayizigidi eziyizinkulungwane ezingama-27.8.I-Euro.I-SAP iphinde yaveza ukuthi ibhizinisi layo leConcur ngeke lisahlomula emalini ehlobene nokuhamba kulo nyaka.Umhlaziyi we-OddoBHF uNicholas David ubhale embikweni ukuthi kunzima ukuthola imiphumela emihle emiphumeleni News.Okulindelwe yimakethe ngezifiso zamaphakathi nethemu kuyethukile, kodwa izifiso ezintsha ziphansi kunalokho okulindelekile okungenathemba.”I-Qualtrics IPOSAP ithe isigaba sayo sesoftware ye-Qualtrics sisesigabeni esithuthukisiwe sokufakwa kuhlu.Yamemezela ngoJulayi ukuthi inqume ukuthola inkampani ngentengo erekhodiwe futhi yavela esidlangalaleni e-US esikhathini esingaphansi kweminyaka emibili.Lokhu kube yinguquko ebingalindelekile futhi kwakhombisa uguquko olunamaqhinga ngaphansi kobuholi buka-Klein."Sithuthuke kakhulu ekulungiseleleni i-IPO ye-Qualtrics," kusho iChief Financial Officer u-Luka Mucic ngocingo ngoMsombuluko."Ukusebenza okuqinile kwe-Qualtrics njalo ngekota kuzobeka isisekelo sokukhula okuqhubekayo ngonyaka ozayo."Umbono omusha wemali engenayo yamafu kulindeleke ukuthi yenyuke isuka ku-8.2 billion euros ngo-2020, yehle kunesilinganiso sangaphambilini sama-euro ayizigidi eziyizinkulungwane eziyi-8.3 siye kuma-euro ayizigidi eziyizinkulungwane ezingama-8.7.Inzuzo yokusebenza kwe-Euro kulo nyaka izoba phakathi kwama-Euro ayizigidi eziyizinkulungwane ezingu-8.1 kanye nama-Euro ayizigidi eziyizinkulungwane ezingu-8.5, okuyinani eliphansi kunaleso elilindelekile lama-Euro ayizigidi eziyizinkulungwane ezingu-8.7.I-SAP inwebise umgomo wayo wamaphakathi wesikhathi sokudlula ama-Euro ayizigidi eziyizinkulungwane ezingu-36 emalini engenayo ngo-2025 futhi izofinyelela ama-Euro ayizigidi eziyizinkulungwane ezingu-35 ngo-2023. , Ngo-2025, imali engenayo ye-cloud computing izodlula ama-euro ayizigidi eziyizinkulungwane ezingu-22 futhi inzuzo yokusebenza izodlula ama-euro ayizigidi eziyizinkulungwane ezingu-11.5.Inzuzo yokusebenza okungeyona ye-IFRS kwikota yesithathu yehle ngo-12% unyaka nonyaka yaya kuma-euro ayizigidi eziyizinkulungwane ezingu-2.07.Uma kuqhathaniswa nama-euro ayizigidi eziyizinkulungwane ezingu-2.15 okulindeleke abahlaziyi abacwaningwe yiBloomberg, imali engenayo phakathi naleso sikhathi yehle ngo-4% yaya ku-6.54 billion wama-euro, kuyilapho isibikezelo somhlaziyi esivamile sasingama-euro ayizigidi eziyizinkulungwane ezingu-6.89., Isikhulu esiphezulu se-SAP nge-PandemicU.K.I-CMA idweba eyayo indlela futhi iqala uphenyo lokungathembeki ngokumelene ne-Sinch, isigaba se-SAP i-DealSAP sidluliselwa ku-JP Morgan Stanley, futhi u-JP Morgan uqhuba i-Qualtrics IPO (izibuyekezo zesitoko, ezinye izimo).Sicela uvakashele i-Bloomberg.com ukuze usivakashele futhi ubhalise manje.Gcina isikhundla esiholayo njengomthombo othembeke kakhulu wezindaba zebhizinisi.©2020 Bloomberg LP
I-accountant yaseSan Francisco ixoxisane ngokubaluleka kwabaphathi be-Biden kumaphothifoliyo wokutshala imali kuzo zonke izingxoxo namakhasimende.
Abasebenzisi abangafakanga i-oda kunoma iyiphi inkundla ye-JD bangathola amakhuphoni esaphulelo!Ngekhadi lakho le-Visa, chofoza ukuze ukhokhe ku-JD.com okokuqala ngqa futhi ujabulele izaphulelo!
Umklomelo kaNobel kwezomnotho, uprofesa waseYunivesithi yaseYale uRobert Shiller unxuse abatshalizimali ukuthi baqaphele mayelana nemakethe yamasheya e-blockbuster kukholamu yakamuva ye-New York Times.
Le nkampani ithe u-Lee Kun-hee, owakha i-Samsung Electronics yaba isiqhwaga somhlaba wonke kuma-smartphones, ama-semiconductors nama-TV, ushone ngeSonto ngemuva kokulaliswa esibhedlela iminyaka engaphezu kweyisithupha ngenxa yesifo senhliziyo ngeSonto.U-Lee uneminyaka engu-78 ubudala kulo nyaka.Wathuthukisa i-Samsung Group yaba yi-conglomerate enkulu kunazo zonke eNingizimu Korea futhi waba indoda ecebile kakhulu eNingizimu Korea.UJeong Sun-, oyi-CEO yenkampani yocwaningo lwenkampani i-Chaebul.com, uthe: “Ukwanda okumangalisayo kuka-Lee eKorea nendlela iNingizimu Korea ehlangana ngayo nokuhwebelana kwembulunga yonke kuwuphawu kangangokuthi ukufa kwakhe kuzokhunjulwa abantu abaningi baseKorea.
Eminyakeni emine ngemuva kokuwa kweBHS, ngabe imboni yocwaningomabhuku ebigxekwa ngokuhluleka ukuthola izinkinga isishintshile?
Ngokwemibiko ye-CNBC, uJack Ma, umsunguli we-Alibaba Group Holdings Limited (NYSE: BABA), uthe ngoMgqibelo i-Ant Group's dual initial public offerings (IPOs) eShanghai naseHong Kong izoba yinkampani enkulu kunazo zonke efakwe ohlwini.Okwenzekile: I-CNBC ithe intengo ye-IPO yayingoLwesihlanu ebusuku, kodwa uJack Ma akazange adalule inombolo ethile, ezomenyezelwa ngesonto elizayo.Umlando womuntu-unqunywe ngaphandle kweDolobha laseNew York.“Kusho uMa Yun engqungqutheleni yaseShanghai Bund.Usozigidi waseChina ubize lolu daba ngokuthi “yisimangaliso.”Wathi: “Asizange silokothe ​​sicabange ngakho eminyakeni emihlanu noma emithathu edlule.“U-Ma Yun uphinde wacela ukuthi kube nezinguquko emabhange kanye nokuthi kusungulwe uhlelo olusha olubandakanya wonke amabhange lomhlaba wonke.Kungani kubalulekile: Ukunikezwa komphakathi kokuqala kwezinkampani ezisekelwa yi-Alibaba kungangenisa imali ecishe ibe yibhiliyoni eyodwa, okuzokwenza kube i-Saudi Aramco Umnikelo womphakathi wokuqala omkhulu kunawo wonke emhlabeni wama-US$29.4 webhiliyoni.Isitoko sika-Aramco esikhishwe ngoDisemba 2019 sehlula i-Alibaba futhi sawina umqhele we-IPO enkulu kunazo zonke.Ngokwemibiko, isikhwama somnotho esizimele sase-Singapore i-GIC Private Limited singafakwa ohlwini lwalezi zinhlu ezimbili.Ukutshalwa kwezimali kudlula US$1 billion.Ngokubika kweReuters, uTemasek waseSingapore, ongumtshali zimali okhona we-Ant, naye uzwakalise ukuthakasela lesi sitoko.Isenzo senani: Intengo yesitoko se-Alibaba ivale cishe i-1.2% ngoLwesihlanu yaya ku-US $309.92.Inyuke ngo-0.11% phakathi neseshini yokuhweba yangemva kwamahora.Amadili amaningi avela ku-Ben Singa *Chofoza lapha ukuze ubuke izinketho zika-Ben Singa * I-Quibi iyabhidlika-lo mbono awuqinile ngokwanele, ubuholi be-Benzinga.com (C) basho ngo-2020: ” Noma “Isikhathi” asikho.I-Benzinga ayinikezi iseluleko sokutshala izimali.wonke Amalungelo Agodliwe.
Nikela ngokushesha ukuze usekele inhlangano yababaleki ye-UN, ukuze ababaleki bathole izinsiza eziphuthumayo zokubhekana nenkathi yemvula futhi babasindise enhlekeleleni!
Kulula ukuthenga amasheya, kodwa kunzima ukuthenga amasheya afanele ngaphandle kwesu elihlolwe isikhathi.Ngakho-ke, yisiphi isitoko esingcono kakhulu ongasithenga noma usifake ohlwini lokubuka manje?
Ikusasa lawa kakhulu.Imakethe yamasheya ingase ihambisane nabaholi abanjengoMicrosoft noTesla.Njengoba sekusondele ukhetho kanye namacala e-coronavirus esanda, leli bekuyisonto lemali engenayo ephezulu kakhulu.
UHarry Markopolos (uHarry Markopolos), owayenguchwepheshe we-derivatives owaphendukela kumphenyi ozimele wokukhwabanisa kwezezimali, wathola uhlelo lwe-Bernie Madoff Ponzi lwamaRandi ayizigidi eziyizinkulungwane ezingu-65, kodwa washaywa indiva yi-SEC iminyaka eyisishiyagalolunye.Njengomgxeki ongagwegwesi wabalawuli baseMelika, uHarry manje ubheka umkhakha wokucwaninga amabhuku kanye nemboni yomshwalense njengecala elikhulu elilandelayo lokukhwabanisa kwezezimali elizodalulwa.
I-annuity entsha ye-inthanethi edonswa intela ye-Hang Seng inikeza iminyaka engu-10 yemali engenayo engashintshi eyengeziwe futhi iqinisekisa u-1.73% -2% wokusetha kabusha imali engenayo yangaphakathi.Kuthatha kuphela imizuzu eyi-10 ukufaka isicelo somshwalense ku-inthanethi futhi uthathe isinyathelo ngokushesha.
Abantu abathathu abajwayelene nalolu daba bathi umdidiyeli ophezulu we-iPhone, iFoxconn yaseTaiwan, usungule iqembu elisebenzayo ukumelana nethonya elikhulayo lomkhiqizi we-elekthronikhi waseChina iLuxshare.Le nkampani ikholelwa ukuthi iLuxshare iwukubusa kwayo.usongo olukhulu.Omunye wemithombo uthe iphrojekthi yaqalwa umsunguli weFoxconn u-Guo Taiming futhi okuhlosiwe yi-Luxshare <002475.SZ> ekomkhulu e-Dongguan.Le nkampani yaziwa kancane emazweni omhlaba, kodwa kulindeleke ukuthi ibe inkampani yokuqala ukuhlangana ezweni laseChina.Indlunkulu ye-iPhone-kuze kube manje, i-turf isabuswa abakhiqizi baseTaiwan.Umthombo uthe iqembu elisebenzayo lasungulwa ngonyaka owedlule futhi beliphenya ubuchwepheshe beLuxshare, izinhlelo zokunweba, isu lokuqasha nokuthi ngabe inkampani (okwamanje ibamba u-5% wemali engenayo kaFoxconn) isekelwa yinoma iyiphi inhlangano kahulumeni waseChina.
Iholo eliyinhloko laleli sonto kanye nombiko wedatha yezomnotho uzokhishwa ngasekupheleni kwaleli sonto, futhi izitoko eziningi ze-FAANG zibikwa ngemva kokuvalwa ngoLwesine.
Umbiko wenzuzo yekota yesithathu ye-AMD (AMD) uhlelelwe ukuthi ukhishwe ngemuva kokuvalwa ngoLwesibili, okuyisikhathi esithokozisayo embonini ye-semiconductor.I-Wall Street Journal ibike ukuthi i-AMD (AMD) ihlela ukukhulisa ibhizinisi layo ngenkuthalo ngokuthengwa okungenzeka (XLNX) (XLNX).Ngaso leso sikhathi, izimbangi zayo ezinkulu (i-INTC) bezisebenza kanzima ukuqhubeka nokukhiqiza ubuchwepheshe bokukhiqiza obusezingeni eliphezulu obudingekayo ukwenza ama-semiconductors ekhwalithi ephezulu.
Thenga ezitolo ezinkulu zemfashini eziku-inthanethi futhi uchithe nekhadi le-Visa ukuze ujabulele isaphulelo esingafika ku-20%!Zitholele amaqoqo akamuva e-Luisa Via Roma kanye no-Taylor manje!
Umhlaziyi weCFRA uGarrett Nelson uthe engxoxweni abe nayo neYahoo Finance ngoLwesihlanu ukuthi uma uJoe Biden (Joe Biden) ewina ukhetho lukamongameli, uTesla (NASDAQ: TSLA) uzoba ophumelele kakhulu.Okwenzekile: UNielsen uthe uTesla "uzoba "enye yezinkampani ezinkulu" eziphumelele ngoba inkampani "iyimoto kagesi emsulwa."Umhlaziyi uveze ukuthi uhulumeni waseBiden uzohlinzeka ngoxhaso olukhulu ezimotweni zikagesi.Abahlaziyi be-CFRA baveze ukuthi i-Biden ihlongoze "ukunwetshwa okukhulu kwezikweletu zentela yezimoto zikagesi" kanye "nokwakhiwa okukhulu kweziteshi zokushaja izimoto zikagesi."UNielsen uthe: “Nicabanga ukwandisa iziteshi zokushaja izimoto zikagesi cishe izikhathi ezingamashumi amabili.Kuzosiza ngempela ukuthandwa kwezimoto zikagesi.“Okubalulekile: Ngesikhathi senkulumompikiswano yokugcina kamongameli eTennessee ngesonto eledlule, uBiden uthe uhulumeni wakhe uzotshala iziteshi zokushaja izimoto zikagesi ezingama-50,000 emgwaqeni omkhulu.Abazongenela ukhetho bathi lezi ziteshi zokushaja zizoholela i-United States ukuthi ibe “nekusasa.”Lowo owayeyiphini likamongameli ukholelwa ukuthi umbono wakhe ngezimoto zikagesi ungabhekana nokushintsha kwesimo sezulu futhi udale “imisebenzi emisha eholela kakhulu.”Inkampani eholwa ngu-Elon Musk imemezele ikota yesithathu ngesonto eledlule Imali engenayo yayingama-US $ 8.77 billion, okuwukunyuka kwama-39% unyaka nonyaka;Isenzo senani: Izabelo zeTesla zivaliwe cishe ngo-1.2% ngoLwesihlanu zaya ku-US $420.63.Uma uJoe Biden ewina i-TSLA DateFirmActionKusukela kwakamuva okhethweni lwango-Okthoba 2020 Izilinganiso uMorgan Stanley ugcina izisindo ezilinganayo (Okthoba 2020) I-Canaccord Genuity igcina ukuhwebelana okwabanjwa ngo-Okthoba 2020 futhi idlula imakethe ngokungathathi hlangothi.Bona izilinganiso zomhlaziyi eziningi ze-TSLA.Bona izilinganiso zakamuva zomhlaziyi* Ukuhlaziya kwakamuva kuka-Benza komsebenzi* u-Rives Musk uthe izinsiza zokuqasha zanyanga zonke zizotholakala ngonyaka ozayo.UJim Kramer uthe uJim Tesla "uyisitoko esihlanyayo" ngo-2020 (C) Benzinga.com, "okungalungile" iBenzinga ayinikezi izeluleko zokutshala imali.Wonke Amalungelo Agodliwe.
Iliphi isu lokutshala izimali elimele isikhathi eside?Ukukhula kwezimali.Ochwepheshe be-Wall Street bakholelwa ukuthi amasheya anamathemba okukhula ngokweqile abonisa ezinye zezitoko eziphoqelela kakhulu.Lawa mandla okukhula angaphezulu kwebanga elikhona manje, futhi la magama azozuza inzuzo enkulu ngo-2020 nangale kwalokho.Lokho kusho, ukusho okuncane, ukuthola amasheya awela kulesi sigaba kungaba inselele.Abahlaziyi bakholelwa ukuthi elinye isu liwukuba uhlehle, ubheke isithombe esikhulu, futhi ugxile ezinkampanini ezinokukhula kwesikhathi eside okusekelwe ezinzuzweni ezihlaba umxhwele zaminyaka yonke.Sikhumbula lokhu, sisebenzise imininingo egciniwe ye-TipRanks ukuze sihlonze izitoko ezintathu zokukhula ezilinganiselwe phezulu abahlaziyi.Zontathu izitoko zithole ukukhula okukhulu ngo-2020 futhi zilungele ukuqhubeka nokukhuphuka.I-Pennsylvania National Game Company (PENN) Okokuqala, singabanikazi beNkampani Yemidlalo Kazwelonke yasePennsylvania, engumnikazi futhi eqhuba izindawo zemidlalo nemijaho kanye namabhizinisi agcina amageyimu evidiyo e-United States.Igama selinyuke ngo-146% ngonyaka kuze kube manje, kodwa abanye abahlaziyi be-Wall Street bakholelwa ukuthi kusenophethiloli omningi ethangini.I-PENN isanda kumemezela imiphumela yayo yekota yesithathu kusenesikhathi, okudlule obekulindelwe.Inkampani ilindele ukuthi amamajini enzuzo ekota akhuphuke ngamaphuzu ayisisekelo angaphezu kuka-900, futhi i-EBITDAR elungisiwe izokhula ngo-5% unyaka nonyaka, noma imali engenayo yehle ngo-10% unyaka nonyaka.Umhlaziyi wezinkanyezi ezinhlanu uJoseph Greff utshele amakhasimende ukuthi "u-JP Morgan Chase" uthe: "Ukuvuselelwa kwemboni yemidlalo yesifunda ngoMeyi/Juni kuqhubeke kwaze kwaba yikota yesithathu, futhi imali engenayo ibingcono kunalokho obekulindelwe.Uma isidingo sesicindezelwe Ngemva kokubuyela kokujwayelekile, futhi njengoba ukusebenza kahle kwe-COVID kwangaphambilini sekuthuthukile, izindleko zokusebenza azikaze zikhuphuke.Phambilini besicabanga ukuthi izinga lokukhula lehlisiwe.”Sengikushilo lokho, uGreif uvumile ukuthi uma kubhekwa ukusebenza kahle kwentengo yesitoko, abanye abahlaziyi bebelokhu beshiya ukwehla ngemuva”.Kodwa-ke, usakholelwa ukuthi "inani kanye ne-catalyst yekusasa".Abahlaziyi baphawule: “…Kukhona ukudonsisana emizweni yabatshalizimali.Sikholelwa ukuthi lokhu kunempilo ezitokweni futhi cishe kudingekile ukuze izitoko ziqhubeke zikhuphuka;sikholelwa ukuthi abatshalizimali bokulingana kwemidlalo yendabuko abazange baxhashazwe ngokuphelele.Sikholelwa ukuthi abatshalizimali bayangabaza mayelana nekhono le-PENN lokuncintisana ne-DraftKings, i-Fanduel, i-Caesars Entertainment, i-MGM/GVC, njll. Usayizi weshidi lebhalansi elihlobene le-PENN ungaxhasa ngezimali izindleko zokutholwa kwamakhasimende okubheja ezemidlalo asekuqaleni, kodwa sikholelwa ukuthi, Ngokubheka ukuthi ukulingana kwakamuva ukuqoqwa kwezimali kukhuphule amaRandi ayizigidi ezingama-950, ubungozi balo mncintiswano buncishisiwe ngebanga elinengqondo. ”Okubaluleke kakhulu, i-PENN isanda kwethula uhlelo lokubheja lwe-Barstool Sports ePennsylvania.UGreff ubize lokhu kukhululwa kwangaphambi kwesikhathi ngokuthi “kuyakhuthaza ngokomthamo wezindleko zokumaketha,” futhi kwafakazela “amandla endlela eyingqayizivele yokuzuza isabelo.”Ngaphezu kwalokho, umfutho weBarstool Sportsbook uyakhula.Okubaluleke nakakhulu, u-Greff ukholelwa ukuthi indawo yamanje yokubheja kwezemidlalo kanye ne-iGaming ifana nokukhuphuka kwezimakethe zesifunda ngeminyaka yawo-1990, lapho izifundazwe ezinokushoda kwesabelomali ziphendukela emithonjeni emisha yemali engenayo, njengemidlalo yezikebhe ukusiza ukumboza isabelomali sazo.ukushoda.Maqondana nalokhu, umhlaziyi uthe: “Sikholelwa ukuthi izwe ngalinye linokucishe kufane okufanayo nge-USB ne-iGaming, futhi i-PENN izoba ngomunye wabawinile.Sithanda iphethini yamageyimu/ukubheja kwezemidlalo/i-iGaming esekelwe emhlabeni e-US futhi sibone indawo yokukhula..”Hhayi-ke akumangazi ukuthi iThuna lihlale nezinkunzi.Ngaphezu kokunikeza isilinganiso "sokukhuluphala ngokweqile", uphinde wabeka intengo yentengo ye-$ 83 yesitoko.Uma lo mgomo ufinyelelwa phakathi nezinyanga eziyishumi nambili ezizayo, abatshalizimali bangase bathole imbuyiselo engu-32%.(Ukuze ubuke irekhodi likaGreif, chofoza lapha.) I-Wall Street yonke ithini?Ukuthenga okuyisishiyagalolunye, ukubamba okuthathu kanye nokudayiswa okukodwa kukhishwe ezinyangeni ezintathu ezedlule.Ngenxa yalokho, i-PENN ithole isilinganiso sokuvumelana "sokuthenga okumaphakathi".Ngokusekelwe esilinganisweni senani elihlosiwe lika-$76.77, intengo yesitoko ingase ikhuphuke ngo-22% ngonyaka ozayo.(Bheka ukuhlaziywa kwesitoko se-Penn National Gaming ku-TipRanks.) I-Redfin (RDFN) I-Redfin iqale ngendawo yokusesha esekelwe kumephu futhi yanweba ububanzi bomkhiqizo wayo ukuze yenze imidlalo yomndeni, imidlalo yokuqala nezinqubo zokubamba ngokushesha futhi zibe lula.Ku-Wall Street, abanye abantu bacabanga ukuthi leli gama aliphathelene nje nokwanda kwesidingo se-COVID, futhi ukuzuza kwayo konyaka kuze kube manje okungu-113% kuyisiqalo nje.Yize i-RDFN isiqedile isibikezelo esiqinile sekota yesithathu, abatshalizimali baphoxekile ngandlela thize ngomphumela.UJake Fuller we-BTIG uveze ukuthi intengo yesitoko ingase yehle ngenxa yokuthi “okulindelwe kuphezulu futhi ukwenyuka okusesilinganisweni kwesilinganiso semali engenayo kulinganiselwa ku-2%” futhi “abatshalizimali abanomfutho bavame ukuklomelisa isigqi esiholwa yivolumu, kuyilapho i-RDFN empeleni isalele ngemuva kwalokhu okulindelekile.”U-Fuller ukholelwa ukuthi i-RDFN ayikona ukunakwa kwabantu abaningi, okubonisa ukuthi abatshalizimali kungenzeka abakubonanga ukudalulwa kweholo.Nokho, ucabanga ukuthi i-Wall Street ingase iphuthelwe yingxenye ebalulekile yephazili.Umhlaziyi wezinkanyezi ezinhlanu uthe: “Okungase kushaywe indiva lapha ukuthi i-RDFN inyuse izinga lekhomishini ngaphandle komthelela omkhulu esilinganisweni sokuguqulwa, okuzothuthukisa kakhulu umbono wesamba senzuzo ye-RDFN.”Kuze kube manje, uzokwenza Inzuzo isiyonke yango-2021 kulindeleke ukuthi inyuke ngo-47%.Uma sibhekisisa imininingwane enemininingwane yekota, i-RDFN ihlangabezane nesidingo esinamandla futhi imali engenayo yezinsizakalo zezindlu ezithengiswayo ikhule ngo-36% unyaka nonyaka.Ithrafikhi yewebhusayithi kanye nevolumu yokwenziwe nakho kwenyukile inyanga nenyanga.Kodwa-ke, kufanele kuqashelwe ukuthi ukukhuphuka kuqhutshwa yimali engenayo yokuthengiselana ngakunye.UFuller uthe: “Lokhu kubalulekile ngoba kukhombisa ukuthi izinga lekhomishini elilindelekile lizogcina linomthelela.”“Ngokwezibalo zethu, imali engenayo yezinsiza zezindlu isuka ku-1.68% we-GTV engxenyeni yesithathu ka-2019 kanye nekota yesibili ka-2020 inyuke ngo-1.78% yafinyelela ku-1.85% engxenyeni yesithathu ka-2020. traffic eliphezulu kule ndawo.Nakuba kunzima ukuhlola ukuphikelela kwesidingo, ukukhuphuka kwentengo kanye nezilinganiso ezingcono zenzuzo kufanele zisimeme “kuphawula uFowler.Ngokuvumelana nethemba lakhe, u-Fuller wasekela izinkunzi, ephinda isilinganiso sokuthenga kanye nenani lesitoko elihlosiwe lika-$65.Leli goli lizwakalisa ukuzethemba kwakhe ngekhono le-RDFN lokunyuka ngo-45% ngonyaka ozayo.(Ukuze ubuke irekhodi lika-Fuller, chofoza lapha.) Lapho uthuthela kwezinye izingxenye ze-Wall Street, imibono yayihlukene nakakhulu.Ezinyangeni ezintathu ezedlule, kuthengwe okuyisi-6, kwabiwa ama-5 kanye nokudayisa oku-1.Ngokusho kwe-Wall Street, i-RDFN iwukuthenga okuphakathi.Isilinganiso senani elihlosiwe lika-$50 lisho ukuphakama okungu-11%.(Bheka ukuhlaziywa kwesitoko se-Redfin ku-TipRanks) I-Vertiv Holdings (VRT) Njengenye yezingxenyekazi zekhompyutha, isofthiwe nabahlinzeki besevisi abahamba phambili emhlabeni, i-Vertiv Holdings isize ukukhuthaza imakethe exhumene yezinhlelo zedijithali, lapho inani elikhulu lezinto ezibalulekile. zidluliselwe, zihlaziywe, zicutshungulwe futhi zigcinwe.I-Wall Street ithe inyuke ngo-71% ​​kuze kube manje kulo nyaka, futhi kungase kube nokunye okuzuziwe.Ngisho noma intengo yesitoko ikhuphuka kakhulu, umhlaziyi weWolfe Research uNigel Coe usakholelwa ukuthi isimo sengozi/somvuzo sihle.Wachaza: “Sikholelwa ukuthi i-Vertiv iwuhlobo oluyivelakancane olungaheha abatshalizimali abaningi: inkampani ekhula ngosayizi omaphakathi enganikeza ukukhula kwenzuzo ekhangayo ngesaphulelo futhi ingaphansi kwesibopho seqembu eliphezulu.”Uma kukhulunywa nge-VRT Endleleni yokukhula, izimakethe zayo eziyinhloko yizikhungo zedatha kanye nezokuxhumana.Lezi zindawo ziyizindawo lapho u-Coe elindele ukuzuza ukukhula ngo-2020 no-2021, kanye nobubi besikhathi eside obulethwa ukwanda okuqhubekayo kokuqina kwedatha kanye nokuthuthukiswa kwe-5G.Ukwengeza, ngenxa yemizamo yokugcina izindleko ezingaguquki zingaguquki ngokuthuthukiswa okuhlukahlukene kokusebenza kanye nokunciphisa inkimbinkimbi yenhlangano, abaphathi baveze indlela yokwandisa inzuzo ibe ngamaphoyinti angu-500."Lona umbhalo osetshenziswe ngempumelelo ngusihlalo omkhulu uDavid Cote ngesikhathi ephethe e-Honeywell, esiqinisekisa ukuthi imibhalo efanayo ingafakwa ku-Vertiv," kusho uCohen.Kuyaphawuleka ukuthi i-VRT ihoxile ngekota yesibili ka-2020, isikweletu sisonke cishe esingaba yizigidi eziyizinkulungwane ezingama-US $ 2.1 kanye nesamba sesikweletu/i-EBITDA esifinyelele izikhathi ezi-4.2.Ngisho nasekupheleni kwalolu hlu, u-Coe ukholelwa ukuthi ishidi lebhalansi lingase lehle ngokushesha.Kuze kube manje, ucabanga ukuthi ngo-2023 isilinganiso se-net / EBITDA siphindwe kabili, khona-ke imali esele izofinyelela ku-1 billion US dollar."Okwamanje asicabangi ukuthi i-Vertiv iyindaba ecacile yokuthunyelwa kwezimali, kodwa lokhu kungase kuvele phakathi nesikhathi sika-2022/23-singabona imisebenzi yokuthenga ukuze sithuthukise amakhono ayo emkhakheni wokusabalalisa amandla kanye nesendlalelo se-DCIM.Okunye okungase kube ongakhetha kukho kubandakanya ukuqedwa kwezincwadi ezigunyaza ukheshi (lokhu okwamanje kubonakala ekubalweni kwethu kwenani lamasheya ahlanjululiwe) kanye nendlela okwabiwa ngayo izinzuzo, okuzokwandisa amathuba okuba ubunikazi besikhungo.Asikwazi futhi ukungaziba iqiniso lokuthi izinto eziningi ezinkulu zikagesi Ububanzi bobambiswano lwamasu olusungulwe ababambiqhaza bemakethe, laba ababambiqhaza ababona ababambiqhaza ababalulekile esikhungweni sedatha.”Yonke into eyenziwe yi-VRT igqugquzele u-Coe ukuthi aphinde ukulinganisa kwakhe kokusebenza kahle kakhulu.Ngenkathi ebiza izinketho, wabeka intengo ehlosiwe ye-$ 23, okusho ukuthi kungenzeka ukuthi i-22% ikhuphuke.(Ukuze ubuke irekhodi lika-Coe, chofoza lapha) Ingabe abanye abahlaziyi bayavuma?kunjalo.Ezinyangeni ezintathu ezedlule, 4 kuphela izilinganiso eziqondile "zokuthenga" ezishicilelwe.Ngakho-ke, umlayezo ucacile: I-VRT ukuthenga okuqinile.Njengoba kunikezwe ukuthi inani lentengo elihlosiwe lingama-$ 20.75, intengo yesitoko ingase ikhuphuke ngo-10% ngonyaka ozayo.(Bheka ukuhlaziywa kwesitoko se-Vertiv Holdings ku-TipRanks) Umshwana wokuzihlangula: Imibono evezwe kulesi sihloko kuphela leyo yomhlaziyi oyinhloko.Okuqukethwe okokubhekisela kuphela.Ngaphambi kokwenza noma yikuphi ukutshalwa kwezimali, kubaluleke kakhulu ukwenza ukuhlaziya kwakho.
IMicrosoft, Apple, Alphabet, Facebook, Amazon, AMD, Caterpillar, Comcast, GE, Ford, Pfixer, Visa, UPS, Exxon Mobil, Twitter nezinye izinkampani zibike imiphumela yazo yekota yesithathu.
Inkundla entsha yokwabelana yama-SME ase-Hong Kong-“i-HSBC Airport” ikuxhuma olwazini lwebhizinisi nemicimbi eyahlukene
Evikini eliphela ngo-Okthoba 22, izilinganiso zenzalo yezindlu eziboshiwe zehle zaba phansi kakhulu.Kulindeleke ukuthi i-COVID-19 nepolitiki yaseMelika ziqhubeke nokuba nomthelela kuleli sonto.
I-Trifecta Stocks izohlonza amasheya e-bearish njalo ngoLwesithathu, futhi kungase kube namathuba athakazelisayo okutshala izimali esikhathini esifushane.Sisebenzisa ukuhlaziya kobuchwepheshe kwalawa mashadi esitoko, futhi lapho kufaneleka khona, ngokusekelwe ezenzweni zakamuva ze-TheStreet's Quant Ratings nezilinganiso, siwakhiphe amagama amahlanu.Nakuba singeke sicabangele ukuhlaziywa okuyisisekelo, sethemba ukuthi lesi sihloko sizonikeza abatshalizimali abanentshisekelo esitokweni isiqalo esihle somsebenzi wesikole oqhubekayo egameni.
Ngemva kweminyaka yokusebenza ngegesi ye-shale yaseMelika, i-Chevron ibheja ikusasa layo legesi yemvelo endaweni eguquguqukayo yaseMpumalanga Ephakathi, futhi ochwepheshe bamandla kade beqaphile.Isinyathelo esiwujuqu sesikhulu esiphezulu sale nkampani uMichael Wirth sisekelwa wukubheja ukuthi iMpumalanga Ephakathi ingena enkathini yokubuyisana, okuzokwenza kube yisinqumo esihle uma kuchithwa igesi yemvelo, njengoba kulindeleke ukuthi ingabizi kakhulu uma kuqhathaniswa nezibaseli ezishibhile nezihlanzekile.Isidingo sizodlula uwoyela.Isu elisha elokuthi inkampani ikhuthaza ukuthengiselana okusha kwegesi yemvelo e-Egypt, Israel, naseQatar, kuyilapho yehlisa ukusetshenziswa kwemali ekuhloleni i-shale e-United States.