Izigidigidi zamadivaysi e-nano-scale agxile ocwaningweni nama-molecule ahlukene athuthukisiwe ukuze asebenze ngaphakathi kwamangqamuzana aphilayo.Nakuba eziningi zalezi zinhlayiya zisebenza kahle kakhulu kulokho ezikwenzayo, ngokuvamile kuwubunzima bokuziletha okuyinselele yangempela ekuzisebenziseni izinjongo ezingokoqobo.Ngokuvamile, uhlobo oluthile lwemikhumbi lusetshenziselwa ukuthwala lezi zinhlayiya kumaseli noma ulwelwesi lweseli luphukile ukuze abahlaseli bangene. Ngakho-ke, lezi zindlela zilimaza amaseli noma azikho kahle kakhulu ekuletheni impahla yazo, futhi okunzima ukuzenza.

Manje, ithimba labahlanganyeli abavela e-Korea University kanye ne-Okinawa Institute of Science and Technology Graduate University e-Japan baye basungula indlela entsha ngokuphelele yokuthola izinhlayiya nezinhlanganisela zamakhemikhali, okuhlanganisa amaprotheni, i-DNA, nezidakamizwa, ngaphakathi kwamaseli ngaphandle kokudala umonakalo omkhulu. .

Indlela entsha incike ekudaleni ama-spiral vortexs azungeze amaseli akhubaza okwesikhashana ulwelwesi lwamaselula isikhathi eside ngokwanele ukuze kungene izinto. I-membrane ibonakala izibuyisela ngokushesha esimeni sazo sasekuqaleni uma ukuvuselela kwe-vortex sekuphelile.Konke lokhu kwenziwa ngesinyathelo esisodwa futhi akudingi noma iyiphi i-biochemistry eyinkimbinkimbi, izimoto zokulethwa kwe-nano, noma ukulimala unomphela kumaseli ahililekile.

Idivayisi eyakhelwe umsebenzi, ebizwa ngokuthi i-spiral hydroporator, ingaletha ama-nanoparticles egolide, i-mesoporous silica nanoparticles esebenzayo, i-dextran, ne-mRNA ezinhlotsheni ezihlukene zamaseli phakathi nomzuzu ngokusebenza kahle okungafika ku-96% kanye nokuphila kwamaselula okungafika ku-94. %.Konke lokhu ngenani elimangalisayo lamaseli angaba yisigidi ngomzuzu nangomshini oshibhile ukuwukhiqiza nolula ukuwusebenzisa.

"Izindlela zamanje zihlushwa ukulinganiselwa okuningi, okuhlanganisa nezinkinga zokulinganisa, izindleko, ukusebenza kahle okuphansi kanye ne-cytotoxicity," kusho uProfesa Aram Chung ovela eSikoleni Sobunjiniyela Bezinto Eziphilayo eKorea University, ohola ucwaningo.“Inhloso yethu bekuwukusebenzisa ama-microfluidics, lapho sasebenzisa khona ukuziphatha kwemisinga yamanzi emincane, ukuze sakhe isisombululo esisha esinamandla sokulethwa kwe-intracellular… i-nanomaterial - phuma kwezinye iziphetho ezimbili.Lonke lolu hlelo luthatha umzuzu owodwa kuphela.”

Ingaphakathi ledivayisi ye-microfluidic inezinhlaka eziphambanayo kanye nezinhlaka ze-T lapho amaseli nama-nanoparticles ageleza khona.Ukulungiswa kwe-junction kudala ama-vortex adingekayo aholela ekungeneni kwe-membrane yeseli kanye nama-nanoparticles angena ngokwemvelo lapho ithuba livela.

Nakhu ukulingiswa kwe-spiral vortex ebangela ukuguquka kweseli empambanweni naku-T-junction:

Ubuchwepheshe bezokwelapha buguqula umhlaba!Hlanganyela nathi futhi ubone inqubekelaphambili ngesikhathi sangempela.Kwa-Medgadget, sibika izindaba zakamuva zobuchwepheshe, abaholi benhlolokhono emkhakheni, kanye nokuthunyelwa kwefayela okuvela ezenzakalweni zezokwelapha emhlabeni wonke kusukela ngo-2004.

Ubuchwepheshe bezokwelapha buguqula umhlaba!Hlanganyela nathi futhi ubone inqubekelaphambili ngesikhathi sangempela.Kwa-Medgadget, sibika izindaba zakamuva zobuchwepheshe, abaholi benhlolokhono emkhakheni, kanye nokuthunyelwa kwefayela okuvela ezenzakalweni zezokwelapha emhlabeni wonke kusukela ngo-2004.